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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Gut hormone PYY3-36 physiologically inhibits food intake

Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature

Regulation of Appetite and ObesityNeuropeptides and Animal Physiology

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The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron

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The cloning of a family of genes that encode the melanocortin receptors

Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science

Neuropeptides and Animal PhysiologyReceptor Mechanisms and Signaling

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Anatomy and regulation of the central melanocortin system

Cone, R. D. (2005) · Nature Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

Initiative, A. N. G., Watson, H. J., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., Bryois, J., Hinney, A., et al. (2019) · Nature Genetics

Eating Disorders and BehaviorsGenetic Associations and Epidemiology

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Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor

Xu, B., Goulding, E. H., Zang, K., Cepoi, D., Cone, R. D., Jones, K. R., Tecott, L. H., & Reichardt, L. F. (2003) · Nature Neuroscience

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

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Studies on the Physiological Functions of the Melanocortin System

Cone, R. D. (2006) · Endocrine Reviews

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Fasting Induces a Large, Leptin-Dependent Increase in the Intrinsic Action Potential Frequency of Orexigenic Arcuate Nucleus Neuropeptide Y/Agouti-Related Protein Neurons

Takahashi, K. A., & Cone, R. D. (2005) · Endocrinology

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Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Collet, T.-H., Dubern, B., Mokrosinski, J., Connors, H., Keogh, J. M., Mendes de Oliveira, E., Henning, E., Poitou-Bernert, C., Oppert, J.-M., Tounian, P., et al. (2017) · Molecular Metabolism

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The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*

Fan, W., Dinulescu, D. M., Butler, A. A., Zhou, J., Marks, D. L., & Cone, R. D. (2000) · Endocrinology

Regulation of Appetite and ObesityPancreatic function and diabetes

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Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

Mullins, N., Kang, J., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., et al. (2022) · Biological Psychiatry

Suicide and Self-Harm StudiesGenetic Associations and Epidemiology

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The Melanocortin-4 Receptor Is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 In Vivo

Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, J. J., et al. (2014) · Cell Metabolism

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RM-493, a melanocortin-4 receptor (MC4R) agonist, increases resting energy expenditure in obese individuals

Chen, K. Y., Muniyappa, R., Abel, B. S., Mullins, K. P., Staker, P., Brychta, R. J., Zhao, X., Ring, M., Psota, T. L., Cone, R. D., et al. (2015) · The Journal of Clinical Endocrinology & Metabolism

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Melanocortin Antagonists Define Two Distinct Pathways of Cardiovascular Control by α- and γ-Melanocyte-Stimulating Hormones

Li, S.-J., Varga, K., Archer, P., Hruby, V. J., Sharma, S. D., Kesterson, R. A., Cone, R. D., & Kunos, G. (1996) · The Journal of Neuroscience

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Regulation of thyrotropin-releasing hormone-expressing neurons in paraventricular nucleus of the hypothalamus by signals of adiposity

Ghamari-Langroudi, M., Vella, K. R., Srisai, D., Sugrue, M. L., Hollenberg, A. N., & Cone, R. D. (2010) · Molecular Endocrinology

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Central receptors mediating the cardiovascular actions of melanocyte stimulating hormones

Ni, X.-P., Butler, A. A., Cone, R. D., & Humphreys, M. H. (2006) · Journal of Hypertension

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Effect of Agouti-related protein in regulation of the hypothalamic-pituitary-thyroid axis in the melanocortin 4 receptor knockout mouse

Fekete, C., Marks, D. L., Sarkar, S., Emerson, C. H., Rand, W. M., Cone, R. D., & Lechan, R. M. (2004) · Endocrinology

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Genetic disruption of γ-melanocyte–stimulating hormone signaling leads to salt-sensitive hypertension in the mouse

Ni, X.-P., Pearce, D., Butler, A. A., Cone, R. D., & Humphreys, M. H. (2003) · Journal of Clinical Investigation

Neuropeptides and Animal PhysiologyRenin-Angiotensin System Studies

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Pineal-specific agouti protein regulates teleost background adaptation

Zhang, C., Song, Y., Thompson, D. A., Madonna, M. A., Millhauser, G. L., Toro, S., Varga, Z., Westerfield, M., Gamse, J., Chen, W., et al. (2010) · Proceedings of the National Academy of Sciences

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Molecular genetics of the acth and melanocyte-stimulating hormone receptors

Cone, R. D., & Mountjoy, K. G. (1993) · Trends in Endocrinology & Metabolism

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Melanocortins

Jégou, S., Cone, R. D., Eberlé, A. N., & Vaudry, H. (2013) · Handbook of Biologically Active Peptides

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