Studies on the Physiological Functions of the Melanocortin System

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479 · see citing works

Ghrelin induces adiposity in rodents

Tschöp, M., Smiley, D. L., & Heiman, M. L. (2000) · Nature · doi:10.1038/35038090 · Cited by 3,949 · see citing works

Targeted disruption of the melanocortin-4 receptor results in obesity in mice

Huszar, D., Lynch, C. A., Fairchild-Huntress, V., Dunmore, J. H., Fang, Q., Berkemeier, L. R., Gu, W., Kesterson, R. A., Boston, B. A., Cone, R. D., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)81865-6 · Cited by 3,030 · see citing works

A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans

Cummings, D. E., Purnell, J. Q., Frayo, R. S., Schmidova, K., Wisse, B. E., & Weigle, D. S. (2001) · Diabetes · doi:10.2337/diabetes.50.8.1714 · Cited by 2,940 · see citing works

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356 · see citing works

Gut hormone PYY3-36 physiologically inhibits food intake

Batterham, R. L., Cowley, M. A., Small, C. J., Herzog, H., Cohen, M. A., Dakin, C. L., Wren, A. M., Brynes, A. E., Low, M. J., Ghatei, M. A., et al. (2002) · Nature · doi:10.1038/nature00887 · Cited by 2,351 · see citing works

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,902 · see citing works

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881 · see citing works

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00063-1 · Cited by 1,679 · see citing works

The cloning of a family of genes that encode the melanocortin receptors

Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635 · see citing works

Cholecystokinin decreases food intake in rats.

Gibbs, J., Young, R. C., & Smith, G. P. (1973) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0034870 · Cited by 1,498 · see citing works

Anatomical evidence of direct projections from the nucleus of the solitary tract to the hypothalamus, amygdala, and other forebrain structures in the rat

Ricardo, J. A., & Koh, E. T. (1978) · Brain Research · doi:10.1016/0006-8993(78)91125-3 · Cited by 1,362 · see citing works

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

Ariyasu, H., Takaya, K., Tagami, T., Ogawa, Y., Hosoda, K., Akamizu, T., Suda, M., Koh, T., Natsui, K., Toyooka, S., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.10.7885 · Cited by 1,282 · see citing works

Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain

Mountjoy, K. G., Mortrud, M. T., Low, M. J., Simerly, R. B., & Cone, R. D. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.10.7854347 · Cited by 1,157 · see citing works

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075 · see citing works

Human distribution and release of a putative new gut hormone, peptide YY

Adrian, T. E., Ferri, G., Bacarese-Hamilton, A. J., Fuessl, H. S., Polak, J. M., & Bloom, S. R. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90211-2 · Cited by 1,064 · see citing works

Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin

Yaswen, L. R., Diehl, N. L., Brennan, M. B., & Hochgeschwender, U. (1999) · Nature Medicine · doi:10.1038/12506 · Cited by 1,010 · see citing works

Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis

Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935 · see citing works

Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass

Chen, A. S., Marsh, D. J., Trumbauer, M. E., Frazier, E. G., Guan, X.-M., Yu, H., Rosenblum, C. I., Vongs, A., Feng, Y., Cao, L., et al. (2000) · Nature Genetics · doi:10.1038/79254 · Cited by 896 · see citing works

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

Robbins, L. S. (1993) · Cell · doi:10.1016/0092-8674(93)90572-8 · Cited by 884 · see citing works

Leptin Increases Hypothalamic Pro-opiomelanocortin mRNA Expression in the Rostral Arcuate Nucleus

Schwartz, M. W., Seeley, R. J., Woods, S. C., Weigle, D. S., Campfield, L. A., Burn, P., & Baskin, D. G. (1997) · Diabetes · doi:10.2337/diab.46.12.2119 · Cited by 879 · see citing works

Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway

Shintani, M., Ogawa, Y., Ebihara, K., Aizawa‐Abe, M., Miyanaga, F., Takaya, K., Hayashi, T., Inoue, G., Hosoda, K., Kojima, M., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.2.227 · Cited by 849 · see citing works

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

Gantz, I., Miwa, H., Konda, Y., Shimoto, Y., Tashiro, T., Watson, S. J., DelValle, J., & Yamada, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82452-8 · Cited by 846 · see citing works

Molecular characterization of the mouse agouti locus

Bultman, S. J., Michaud, E. J., & Woychik, R. P. (1992) · Cell · doi:10.1016/s0092-8674(05)80067-4 · Cited by 805 · see citing works

Agouti-related peptide–expressing neurons are mandatory for feeding

Gropp, E., Shanabrough, M., Borók, E., Xu, A. W., Janoschek, R., Buch, T., Plum, L., Balthasar, N., Hampel, B., Waisman, A., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1548 · Cited by 800 · see citing works

cDNA eloping of bovine substance-K receptor through oocyte expression system

Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M., & Nakanishi, S. (1987) · Nature · doi:10.1038/329836a0 · Cited by 744 · see citing works

Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system.

Roselli-Rehfuss, L., Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., Low, M. J., Tatro, J. B., Entwistle, M. L., Simerly, R. B., & Cone, R. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.8856 · Cited by 722 · see citing works

A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

Butler, A. A., Kesteson, R. A., Khong, K., Cullen, M. J., Pelleymounter, M. A., DeKoning, J., Baetscher, M., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7791 · Cited by 703 · see citing works

Post-prandial decrease of circulating human ghrelin levels

Tschöp, M., Wawarta, R., Riepl, R. L., Friedrich, S., Bidlingmaier, M., Landgraf, R., & Folwaczny, C. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03351037 · Cited by 699 · see citing works

Molecular cloning of a novel melanocortin receptor.

Gantz, I., Konda, Y., Tashiro, T., Shimoto, Y., Miwa, H., Munzert, G. M., Watson, S. J., DelValle, J., & Yamada, T. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53088-x · Cited by 681 · see citing works

Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat

Willesen, M. G., Kristensen, P., & Rømer, J. (1999) · Neuroendocrinology · doi:10.1159/000054491 · Cited by 605 · see citing works

Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA

Chhajlani, V., & Wikberg, J. E. S. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)80820-7 · Cited by 593 · see citing works

Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat

Kishi, T., Aschkenasi, C. J., Lee, C. E., Mountjoy, K. G., Saper, C. B., & Elmquist, J. K. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10454 · Cited by 581 · see citing works

Response of melanocortin–4 receptor–deficient mice to anorectic and orexigenic peptides

Marsh, D. J., Hollopeter, G., Huszar, D., Laufer, R., Yagaloff, K. A., Fisher, S. L., Burn, P., & Palmiter, R. D. (1999) · Nature Genetics · doi:10.1038/5070 · Cited by 545 · see citing works

Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin

Mizuno, T. M., Kleopoulos, S. P., Bergen, H., Roberts, J. L., Priest, C. A., & Mobbs, C. V. (1998) · Diabetes · doi:10.2337/diab.47.2.294 · Cited by 521 · see citing works

Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor

Kojima, M., Hosoda, H., Matsuo, H., & Kangawa, K. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00362-3 · Cited by 515 · see citing works

Constitutively active mutants of rhodopsin

Robinson, P. R., Cohen, G. B., Zhukovsky, E. A., & Oprian, D. D. (1992) · Neuron · doi:10.1016/0896-6273(92)90034-b · Cited by 514 · see citing works

Activation of Central Melanocortin Pathways by Fenfluramine

Heisler, L. K., Cowley, M. A., Tecott, L. H., Fan, W., Low, M. J., Smart, J. L., Rubinstein, M., Tatro, J. B., Marcus, J., Holstege, H. H., et al. (2002) · Science · doi:10.1126/science.1072327 · Cited by 491 · see citing works

Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides

Chen, W., Kelly, M. A., Opitz-Araya, X., Thomas, R. E., Low, M. J., & Cone, R. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80467-5 · Cited by 488 · see citing works

Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation.Preprint

Miller, M. W., Duhl, D. M. J., Vrieling, H., Cordes, S. P., Ollmann, M. M., Winkes, B. M., & Barsh, G. S. (1993) · Genes & Development · doi:10.1101/gad.7.3.454 · Cited by 430 · see citing works

Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain

Bagnol, D., Lu, X.-Y., Kaelin, C. B., Day, H. E. W., Ollmann, M., Gantz, I., Akil, H., Barsh, G. S., & Watson, S. J. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-18-j0004.1999 · Cited by 425 · cited 1× · see citing works

Control and function of sebaceous glands

Thody, A. J., & Shuster, S. (1989) · Physiological Reviews · doi:10.1152/physrev.1989.69.2.383 · Cited by 401 · see citing works

Overexpression of Agrt leads to obesity in transgenic mice

Graham, M., Shutter, J. R., Sarmiento, U. M., Sarosi, L., & Stark, K. L. (1997) · Nature Genetics · doi:10.1038/ng1197-273 · Cited by 387 · see citing works

Hypothalamic Agouti-Related Protein Messenger Ribonucleic Acid Is Inhibited by Leptin and Stimulated by Fasting*

Mizuno, T. M., & Mobbs, C. V. (1999) · Endocrinology · doi:10.1210/endo.140.2.6491 · Cited by 387 · see citing works

The coat colours of mice. A model for mammalian gene action and interaction.

Silvers, W. K. (1979) · Springer eBooks · Cited by 386 · see citing works

Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter

Liu, H., Kishi, T., Roseberry, A. G., Cai, X., Lee, C. E., Montez, J. M., Friedman, J. M., & Elmquist, J. K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-18-07143.2003 · Cited by 375 · see citing works

Mice lacking pro-opiomelanocortin are sensitive to high-fat feeding but respond normally to the acute anorectic effects of peptide-YY 3-36

Challis, B., Coll, A. P., Yeo, G. S. H., Pinnock, S. B., Dickson, S. L., Thresher, R. R., Dixon, J. B., Zahn, D., Rochford, J. J., White, A. E., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306931101 · Cited by 368 · see citing works

Two molecular forms of Peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1–36 and PYY 3–36

Grandt, D., Schimiczek, M., Beglinger, C., Layer, P., Goebell, H., Eysselein, V. E., & Reeve, J. R. (1994) · Regulatory Peptides · doi:10.1016/0167-0115(94)90204-6 · Cited by 363 · see citing works

Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic

Haynes, W. G., Morgan, D. A., Djalali, A., Sivitz, W. I., & Mark, A. L. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.542 · Cited by 358 · see citing works

Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats

Hewson, A. K., & Dickson, S. L. (2000) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2000.00584.x · Cited by 357 · see citing works

Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

Hrubu, V. J., Lu, D., Sharma, S. D., Castrucci, A. M. D. L., Kesterson, R. A., Al‐Obeidi, F., Hadley, M. E., & Cone, R. D. (1995) · Journal of Medicinal Chemistry · doi:10.1021/jm00018a005 · Cited by 349 · see citing works

Molecular Cloning of a Novel Human Melanocortin Receptor

Chhajlani, V., Muceniece, R., & Wikberg, J. E. S. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2125 · Cited by 333 · see citing works

Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat

Butler, A. A., Marks, D. L., Fan, W., Kuhn, C. M., Bartolome, M. B., & Cone, R. D. (2001) · Nature Neuroscience · doi:10.1038/88423 · Cited by 332 · see citing works

Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus

Wang, L., Saint-Pierre, D. H., & Taché, Y. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00241-0 · Cited by 326 · see citing works

Physiology: Does gut hormone PYY3–36 decrease food intake in rodents?

Tschöp, M., Castañeda, T. R., Joost, H., Thöne-Reineke, C., Ortmann, S., Klaus, S., Hagan, M. M., Chandler, P. C., Oswald, K., Benoit, S. C., et al. (2004) · Nature · doi:10.1038/nature02665 · Cited by 311 · see citing works

Fasting Induces a Large, Leptin-Dependent Increase in the Intrinsic Action Potential Frequency of Orexigenic Arcuate Nucleus Neuropeptide Y/Agouti-Related Protein Neurons

Takahashi, K. A., & Cone, R. D. (2005) · Endocrinology · doi:10.1210/en.2004-1397 · Cited by 308 · see citing works

Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

Fan, W., Ellacott, K. L. J., Halatchev, I. G., Takahashi, K. A., Yu, P., & Cone, R. D. (2004) · Nature Neuroscience · doi:10.1038/nn1214 · Cited by 306 · see citing works

Obesity, diabetes, and neoplasia in yellow A vy /‐ mice: ectopic expression of the agouti gene

Yen, T. T. T., Gill, A. M., Frigeri, L. G., Barsh, G. S., & Wolff, G. L. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.8.8181666 · Cited by 305 · see citing works

Molecular Cloning, Expression, and Characterization of a Fifth Melanocortin Receptor

Gantz, I., Shimoto, Y., Konda, Y., Miwa, H., Dickinson, C. J., & Yamada, T. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1580 · Cited by 302 · see citing works

The Central Melanocortin System Can Directly Regulate Serum Insulin Levels*

Fan, W., Dinulescu, D. M., Butler, A. A., Zhou, J., Marks, D. L., & Cone, R. D. (2000) · Endocrinology · doi:10.1210/endo.141.9.7665 · Cited by 294 · see citing works

Role of the central melanocortin system in cachexia.

Marks, D. L., LING, N. C., & Cone, R. D. (2001) · PubMed · Cited by 289 · see citing works

Brainstem Application of Melanocortin Receptor Ligands Produces Long-Lasting Effects on Feeding and Body Weight

Grill, H. J., Ginsberg, A. B., Seeley, R. J., & Kaplan, J. M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-23-10128.1998 · Cited by 277 · see citing works

Cholecystokinin-decreased food intake in rhesus monkeys

Gibbs, J., Falasco, J., & McHugh, P. (1976) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1976.230.1.15 · Cited by 274 · see citing works

Independent and Additive Effects of Central POMC and Leptin Pathways on Murine Obesity

Boston, B. A., Blaydon, K. M., Varnerin, J. P., & Cone, R. D. (1997) · Science · doi:10.1126/science.278.5343.1641 · Cited by 239 · see citing works

ACTH-(1–24) and α-MSH antagonize feeding behavior stimulated by kappa opiate agonists

Poggioli, R., Vergoni, A. V., & Bertolini, A. (1986) · Peptides · doi:10.1016/0196-9781(86)90104-x · Cited by 237 · see citing works

Peptide YY3–36Inhibits Food Intake in Mice through a Melanocortin-4 Receptor-Independent Mechanism

Halatchev, I. G., Ellacott, K. L. J., Fan, W., & Cone, R. D. (2004) · Endocrinology · doi:10.1210/en.2003-1754 · Cited by 236 · see citing works

Central leptin modulates behavioral and neural responsivity to CCK

Emond, M. H., Schwartz, G. J., Ladenheim, E. E., & Moran, T. H. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1545 · Cited by 225 · see citing works

Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1.

Cannon, J. G., Tatro, J. B., Reichlin, S., & Dinarello, C. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.7.2232 · Cited by 220 · see citing works

Factors Regulating Growth And Pigmentation Of Melanoma Cells

Pawelek, J. M. (1976) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12482134 · Cited by 219 · see citing works

ART (Protein Product of Agouti-Related Transcript) as an Antagonist of MC-3 and MC-4 Receptors

Fong, T. M., Mao, C., MacNeil, T., Kalyani, R. N., Smith, T., Weinberg, D., Tota, M. R., & der Ploeg, L. H. T. V. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7200 · Cited by 219 · see citing works

A non-epistatic interaction of agouti and extension in the fox, Vulpes vulpes

Våge, D. I., Lu, D., Klungland, H., Lien, S., ADALSTEINSSON, S., & Cone, R. D. (1997) · Nature Genetics · doi:10.1038/ng0397-311 · Cited by 214 · see citing works

Distribution of cDNA for melanocortin receptor subtypes in human tissues.

Chhajlani, V. (1996) · PubMed · Cited by 213 · see citing works

The Melanotropins: Chemistry, Physiology and Mechanisms of Action

Eberlé, A. N. (1988) · Medical Entomology and Zoology · Cited by 212 · see citing works

Molecular Cloning of a Mouse Melanocortin 5 Receptor Gene Widely Expressed in Peripheral Tissues

Labbé, O., Désarnaud, F., Eggerickx, D., Vassart, G., & Parmentier, M. (1994) · Biochemistry · doi:10.1021/bi00181a015 · Cited by 212 · see citing works

Molecular and pharmacological characterization of dominant black coat color in sheep

Våge, D. I., Klungland, H., Lu, D., & Cone, R. D. (1999) · Mammalian Genome · doi:10.1007/s003359900939 · Cited by 212 · see citing works

Effects of Hypothalamic Neurodegeneration on Energy Balance

Xu, A. W., Kaelin, C. B., Morton, G. J., Ogimoto, K., Stanhope, K. L., Graham, J. L., Baskin, D. G., Havel, P. J., Schwartz, M. W., & Barsh, G. S. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030415 · Cited by 211 · see citing works

The mouse mahogany locus encodes a transmembrane form of human attractin

Gunn, T. M., Miller, K. A., He, L., et al. (1999) · Nature · doi:10.1038/18217 · Cited by 209 · see citing works

Neuropeptide Y-Mediated Inhibition of Proopiomelanocortin Neurons in the Arcuate Nucleus Shows Enhanced Desensitization in ob/ob Mice

Roseberry, A. G., Liu, H., Jackson, A. C., Cai, X., & Friedman, J. M. (2004) · Neuron · doi:10.1016/s0896-6273(04)00074-1 · Cited by 198 · see citing works

Lessons from constitutively active mutants of G protein-coupled receptors

Parnot, C., Miserey‐Lenkei, S., Bardin, S., Corvol, P. L., & Clauser, É. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(02)00628-8 · Cited by 195 · see citing works

Molecular Cloning and Characterisation of the Rat Fifth Melanocortin Receptor

Griffon, N., Mignon, V., Facchinetti, P., Díaz, J., Schwartz, J., & Sokoloff, P. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1550 · Cited by 195 · see citing works

Fasting Regulates Hypothalamic Neuropeptide Y, Agouti-Related Peptide, and Proopiomelanocortin in Diabetic Mice Independent of Changes in Leptin or Insulin1

Mizuno, T. M., Makimura, H., Silverstein, J. H., Roberts, J. L., Lopingco, T., & Mobbs, C. V. (1999) · Endocrinology · doi:10.1210/endo.140.10.6966 · Cited by 189 · see citing works

Peripheral administration of PYY3–36 produces conditioned taste aversion in mice

Halatchev, I. G., & Cone, R. D. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.02.003 · Cited by 186 · see citing works

A Colorimetric Assay for Measuring Activation of Gs- and Gq-Coupled Signaling Pathways

Chen, W. B., Shields, T., Stork, P. A., et al. (1995) · Analytical Biochemistry · doi:10.1006/abio.1995.1235 · Cited by 186 · see citing works

Peptide YY ablation in mice leads to the development of hyperinsulinaemia and obesity

Boey, D., Lin, S., Karl, T., Baldock, P., Lee, N., Enriquez, R., Couzens, M., Slack, K., Dallmann, R., Sainsbury, A., et al. (2006) · Diabetologia · doi:10.1007/s00125-006-0237-0 · Cited by 186 · see citing works

The mahogany protein is a receptor involved in suppression of obesity

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