Kaech, Susan M.

Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 2,103

Mitochondrial DNA stress primes the antiviral innate immune response

West, A. P., Khoury-Hanold, W., Staron, M., Tal, M. C., Pineda, C. M., Lang, S. M., Bestwick, M., Duguay, B. A., Raimundo, N., MacDuff, D. A., et al. (2015) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 1,975

Effector and memory T-cell differentiation: implications for vaccine development

Kaech, S. M., Wherry, E. J., & Ahmed, R. (2002) · Nature Reviews Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 1,865

Lineage relationship and protective immunity of memory CD8 T cell subsets

Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 1,864

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 1,861

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 1,830

Transcriptional control of effector and memory CD8+ T cell differentiation

Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 1,628

Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses

Ho, P.-C., Bihuniak, J. D., Macintyre, A. N., Staron, M., Liu, X., Amezquita, R., Tsui, Y.-C., Cui, G., Micevic, G., Perales, J. C., et al. (2015) · Cell

Cancer, Hypoxia, and MetabolismCancer Immunotherapy and Biomarkers

Cited by 1,462

Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer

Gettinger, S., Choi, J., Hastings, K., Truini, A., Datar, I., Sowell, R., Wurtz, A., Dong, W., Cai, G., Melnick, M. A., et al. (2017) · Cancer Discovery

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 787

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

Perry, R. J., Camporez, J.-P. G., Kursawe, R., Titchenell, P. M., Zhang, D., Perry, C. J., Jurczak, M. J., Abudukadier, A., Han, M. S., Zhang, X.-M., et al. (2015) · Cell

Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesis

Cited by 719

The multifaceted role of CD4+ T cells in CD8+ T cell memory

Laidlaw, B. J., Craft, J. E., & Kaech, S. M. (2016) · Nature Reviews Immunology

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 657

Heterologous immunity provides a potent barrier to transplantation tolerance

Adams, A. B., Williams, M. A., Jones, T. R., Shirasugi, N., Durham, M. M., Kaech, S. M., Wherry, E. J., Onami, T., Lanier, J. G., Kokko, K. E., et al. (2003) · Journal of Clinical Investigation

T-cell and B-cell ImmunologyTransplantation: Methods and Outcomes

Cited by 616

An interleukin-21-interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells

Cui, W., Liu, Y., Weinstein, J. S., Craft, J., & Kaech, S. M. (2011) · Immunity

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 410

The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells

Kaech, S. M., Whitfield, C. W., & Kim, S. K. (1998) · Cell

Developmental Biology and Gene RegulationCellular transport and secretion

Cited by 375

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

Ray, J. P., Staron, M. M., Shyer, J. A., Ho, P.-C., Marshall, H. D., Gray, S. M., Laidlaw, B. J., Araki, K., Ahmed, R., Kaech, S. M., et al. (2015) · Immunity

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 315

UV‐induced somatic mutations elicit a functional T cell response in the YUMMER 1.7 mouse melanoma model

Wang, J., Perry, C. J., Meeth, K., Thakral, D., Damsky, W., Micevic, G., Kaech, S., Blenman, K., & Bosenberg, M. (2017) · Pigment Cell & Melanoma Research

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 199

Bile acid synthesis impedes tumor-specific T cell responses during liver cancer

Varanasi, S. K., Chen, D., Liu, Y., Johnson, M. A., Miller, C. M., Ganguly, S., Lande, K., LaPorta, M. A., Hoffmann, F. A., Mann, T. H., et al. (2025) · Science

Cancer Immunotherapy and BiomarkersDrug Transport and Resistance Mechanisms

Cited by 177

Immune-based antitumor effects of BRAF inhibitors rely on signaling by CD40L and IFNγ

Ho, P.-C., Meeth, K. M., Tsui, Y.-C., Srivastava, B., Bosenberg, M. W., & Kaech, S. M. (2014) · Cancer Research

Cancer Immunotherapy and BiomarkersMelanoma and MAPK Pathways

Cited by 126

Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection

Kasmani, M. Y., Zander, R., Chung, H. K., Chen, Y., Khatun, A., Damo, M., Topchyan, P., Johnson, K. E., Levashova, D., Burns, R., et al. (2023) · Journal of Experimental Medicine

T-cell and B-cell ImmunologyCancer Immunotherapy and Biomarkers

Cited by 87

Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults

Mohanty, S., Joshi, S. R., Ueda, I., Wilson, J., Blevins, T. P., Siconolfi, B., Meng, H., Devine, L., Raddassi, K., Tsang, S., et al. (2015) · Journal of Infectious Diseases

Immune responses and vaccinationsInfluenza Virus Research Studies

Cited by 67

A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression

Myers, L. M., Tal, M. C., Torrez Dulgeroff, L. B., Carmody, A. B., Messer, R. J., Gulati, G., Yiu, Y. Y., Staron, M. M., Angel, C. L., Sinha, R., et al. (2019) · Nature Communications

T-cell and B-cell ImmunologyPhagocytosis and Immune Regulation

Cited by 66