Clonal lineage tracing reveals mechanisms skewing CD8+ T cell fate decisions in chronic infection

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Restoring function in exhausted CD8 T cells during chronic viral infection

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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection

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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

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Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

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Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired

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TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion

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Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment

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Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

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The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function

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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

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Clonal Exhaustion as a Mechanism to Protect Against Severe Immunopathology and Death from an Overwhelming CD8 T Cell Response

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Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches

Dähling, S., Mansilla, A. M., Knöpper, K., Grafen, A., Utzschneider, D. T., Ugur, M., Whitney, P. G., Bachem, A., Arampatzi, P., Imdahl, F., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.03.006 · Cited by 109 · see citing works

pMHC affinity controls duration of CD8+ T cell–DC interactions and imprints timing of effector differentiation versus expansion

Ozga, A. J., Moalli, F., Abe, J., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160206 · Cited by 108 · see citing works

Reverse TCR repertoire evolution toward dominant low-affinity clones during chronic CMV infection

Schober, K., Voit, F., Grassmann, S. A., Müller, T. R., Eggert, J., Jarosch, S., Weißbrich, B., Hoffmann, P., Borkner, L., Nio, E., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0628-2 · Cited by 107 · see citing works

Association Between Immune-Related Adverse Events and Clinical Efficacy in Patients with Melanoma Treated With Nivolumab: A Multicenter Retrospective Study

Okada, N., Kawazoe, H., Takechi, K., Matsudate, Y., Utsunomiya, R., Zamami, Y., Goda, M., Imanishi, M., Chuma, M., Hidaka, N., et al. (2019) · Clinical Therapeutics · doi:10.1016/j.clinthera.2018.11.004 · Cited by 96 · see citing works

T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells

Conley, J. M., Gallagher, M. P., & Berg, L. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00076 · Cited by 87 · see citing works

Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-α/β

Ngoi, S. M., Tovey, M. G., & Vella, A. T. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.11.7670 · Cited by 78 · see citing works

Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection

Sandu, I., Cerletti, D., Oetiker, N., Borsa, M., Wagen, F., Spadafora, I., Welten, S. P. M., Stolz, U., Oxenius, A., & Claassen, M. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108078 · Cited by 76 · see citing works

IL-27 promotes the expansion of self-renewing CD8+ T cells in persistent viral infection

Huang, Z., Žák, J., Pratumchai, I., Shaabani, N., Vartabedian, V. F., Nguyen, N., Wu, T., Xiao, C., & Teijaro, J. R. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190173 · Cited by 71 · see citing works

Vaccination with High-Affinity Epitopes Impairs Antitumor Efficacy by Increasing PD-1 Expression on CD8+ T Cells

Zahm, C. D., Colluru, V. T., & McNeel, D. G. (2017) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-16-0374 · Cited by 68 · see citing works

Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire

Khatun, A., Kasmani, M. Y., Zander, R., Schauder, D., Snook, J. P., Shen, J., Wu, X., Burns, R., Chen, Y., Lin, C., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20200650 · Cited by 67 · see citing works

Abrogation of Src Homology Region 2 Domain-Containing Phosphatase 1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo

Stromnes, I. M., Fowler, C., Casamina, C. C., Georgopolos, C. M., McAfee, M. S., Schmitt, T. M., Tan, X., Kim, T., Choi, I., Blattman, J. N., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200552 · Cited by 66 · see citing works

SHP-1 in T Cells Limits the Production of CD8 Effector Cells without Impacting the Formation of Long-Lived Central Memory Cells

Fowler, C., Pao, L. I., Blattman, J. N., & Greenberg, P. D. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001362 · Cited by 59 · see citing works

TCRpMHCmodels: Structural modelling of TCR-pMHC class I complexes

Jensen, K. K., Rantos, V., Jappe, E. C., Olsen, T. H., Jespersen, M. C., Jurtz, V. I., Jessen, L. E., Lanzarotti, E., Mahajan, S., Peters, B., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50932-4 · Cited by 59 · see citing works

Antigen amount dictates CD 8 + T ‐cell exhaustion during chronic viral infection irrespective of the type of antigen presenting cell

Richter, K., Brocker, T., & Oxenius, A. (2012) · European Journal of Immunology · doi:10.1002/eji.201142275 · Cited by 55 · see citing works

Proliferation-competent Tcf1+ CD8 T cells in dysfunctional populations are CD4 T cell help independent

Kanev, K., Wu, M., Drews, A., Roelli, P., Wurmser, C., von Hoesslin, M., & Zehn, D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902701116 · Cited by 50 · see citing works

Immune-related adverse events are associated with improved outcomes in ICI-treated renal cell carcinoma patients.

Elias, R., Yan, F., Singla, N., Levonyack, N., Formella, J., Christie, A., Kapur, P., Bowman, A. I., Hammers, H. J., Hannan, R., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.2019.37.7_suppl.645 · Cited by 48 · see citing works

TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency

Allard, M., Couturaud, B., Carretero-Iglesia, L., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.92570 · Cited by 45 · see citing works

Inhibition of SHP-1 Expands the Repertoire of Antitumor T Cells Available to Respond to Immune Checkpoint Blockade

Snook, J. P., Soedel, A. J., Ekiz, H. A., O’Connell, R. M., & Williams, M. A. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0690 · Cited by 39 · see citing works

Role of Interferon Regulatory Factor 7 in T Cell Responses during Acute Lymphocytic Choriomeningitis Virus Infection

Zhou, S., Cerny, A., Fitzgerald, K. A., Kurt‐Jones, E. A., & Finberg, R. W. (2012) · Journal of Virology · doi:10.1128/jvi.00576-12 · Cited by 32 · see citing works

Identification of a T-bethi Quiescent Exhausted CD8 T Cell Subpopulation That Can Differentiate into TIM3+CX3CR1+ Effectors and Memory-like Cells

Raju, S., Xia, Y., Dániel, B., Yost, K. E., Bradshaw, E., Tonc, E., Verbaro, D., Kometani, K., Yokoyama, W. M., Kurosaki, T., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001348 · Cited by 28 · see citing works

Trib1 regulates T cell differentiation during chronic infection by restraining the effector program

Rome, K., Stein, S. J., Kurachi, M., Petrovic, J., Schwartz, G. W., Mack, E. A., Uljon, S., Wu, W. W., DeHart, A. G., McClory, S., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190888 · Cited by 27 · see citing works

POLY I:C, AN INDUCER OF INTERFERON AND INTERFERENCE AGAINST VIRUS INFECTIONS

Field, A., TYTELL, A. A., Piperno, E., et al. (1972) · Medicine · doi:10.1097/00005792-197205000-00002 · Cited by 24 · see citing works

Clonal Repertoires of Virus-Specific CD8+ T Lymphocytes Are Shared in Mucosal and Systemic Compartments during Chronic Simian Immunodeficiency Virus Infection in Rhesus Monkeys

Sircar, P., Furr, K. L., Dorosh, L. A., & Letvin, N. (2010) · Journal of Immunology · doi:10.4049/jimmunol.1001340 · Cited by 16 · see citing works

Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice

Li, W., Hofer, M. J., Noçon, A. L., Manders, P., & Campbell, I. L. (2013) · Virology · doi:10.1016/j.virol.2013.02.015 · Cited by 16 · see citing works

T Cell Receptor Diversity and Lineage Relationship between Virus-Specific CD8 T Cell Subsets during Chronic Lymphocytic Choriomeningitis Virus Infection

Chang, D. Y., Wieland, A., Li, Z.-R. T., Im, S. J., McGuire, D. J., Kissick, H. T., Antia, R., & Ahmed, R. (2020) · Journal of Virology · doi:10.1128/jvi.00935-20 · Cited by 16 · see citing works

Profiling Virus-Specific Tcf1+ T Cell Repertoires During Acute and Chronic Viral Infection

Yermanos, A., Sandu, I., Pedrioli, A., Borsa, M., Wagen, F., Oetiker, N., Welten, S. P. M., Pallmer, K., Reddy, S. T., & Oxenius, A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00986 · Cited by 10 · see citing works

The technological landscape and applications of single-cell multi-omics

Baysoy, A., Bai, Z., Satija, R., & Fan, R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00615-w · Cited by 1,037 · see citing works

The Nr4a family regulates intrahepatic Treg proliferation and liver fibrosis in MASLD models

Aki, D., Hayakawa, T., Srirat, T., Shichino, S., Ito, M., Saitoh, S.-I., Mise-Omata, S., & Yoshimura, A. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175305 · Cited by 22 · see citing works

20 Effector proteins of bacterial type III protein secretion systems: Elucidating their biochemical effects on eukaryotic signaling cascades

Orth, K., Dixon, J. E., & Bliska, J. B. (2002) · Methods in microbiology · doi:10.1016/s0580-9517(02)31021-3

Crucial Roles of Effectors in Interactions between Horticultural Crops and Pathogens

Liu, T., Chen, Y., Tian, S., et al. (2023) · Horticulturae · doi:10.3390/horticulturae9020250 · Cited by 9 · see citing works

Prediction of effector proteins and their implications in pathogenicity of phytopathogenic filamentous fungi: A review

Wu, Y., Xie, L., Jiang, Y., & Li, T. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.02.133 · Cited by 35 · see citing works

Microbial Pathogen Effectors in Plant Disease

Pelgrom, A. J. E., & den Ackerveken, G. F. J. M. V. (2016) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0023724 · Cited by 7 · see citing works

Remote homology clustering identifies lowly conserved families of effector proteins in plant-pathogenic fungi

Jones, D., Moolhuijzen, P., & Hane, J. K. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000637 · Cited by 13 · see citing works