Holmes, Michael V.

Education and coronary heart disease: mendelian randomisation study

Tillmann, T., Vaucher, J., Okbay, A., Pikhart, H., Peasey, A., Kubinova, R., Pajak, A., Tamosiunas, A., Malyutina, S., Hartwig, F. P., et al. (2017) · BMJ

Genetic Associations and EpidemiologyCardiovascular Health and Risk Factors

Cited by 225

Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis

Holmes, M. V., Lange, L. A., Palmer, T., Lanktree, M. B., North, K. E., Almoguera, B., Buxbaum, S., Chandrupatla, H. R., Elbers, C. C., Guo, Y., et al. (2014) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 216

Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development

Holmes, M. V., Richardson, T. G., Ference, B. A., Davies, N. M., & Davey Smith, G. (2021) · Nature Reviews Cardiology

Genetic Associations and EpidemiologyLipoproteins and Cardiovascular Health

Cited by 184

Cholesteryl Ester Transfer Protein Inhibition for Preventing Cardiovascular Events

Armitage, J., Holmes, M. V., & Preiss, D. (2019) · Journal of the American College of Cardiology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 140

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis.

White, J., Sofat, R., Hemani, G., Shah, T., Engmann, J., Dale, C., Shah, S., Kruger, F. A., Giambartolomei, C., Swerdlow, D. I., et al. (2016) · The Lancet Diabetes & Endocrinology

Gout, Hyperuricemia, Uric AcidGenetic Associations and Epidemiology

Cited by 132

Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics

Bovijn, J., Krebs, K., Chen, C.-Y., Boxall, R., Censin, J. C., Ferreira, T., Pulit, S. L., Glastonbury, C. A., Laber, S., Millwood, I. Y., et al. (2020) · Science Translational Medicine

Bone health and osteoporosis researchGenetic Associations and Epidemiology

Cited by 119

Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women

Peters, S. A. E., Yang, L., Guo, Y., Chen, Y., Bian, Z., Du, J., Yang, J., Li, S., Li, L., Woodward, M., et al. (2017) · Journal of the American Heart Association

Breastfeeding Practices and InfluencesCancer Risks and Factors

Cited by 118

Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment

Sliz, E., Kettunen, J., Holmes, M. V., Williams, C. O., Boachie, C., Wang, Q., Männikkö, M., Sebert, S., Walters, R., Lin, K., et al. (2018) · Circulation

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 109

Smoking and smoking cessation in relation to risk of diabetes in Chinese men and women: a 9-year prospective study of 0·5 million people

Liu, X., Bragg, F., Yang, L., Kartsonaki, C., Guo, Y., Du, H., Bian, Z., Chen, Y., Yu, C., Lv, J., et al. (2018) · The Lancet Public Health

Smoking Behavior and CessationDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 94

Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis

Wang, Q., Oliver-Williams, C., Raitakari, O. T., Viikari, J., Lehtimäki, T., Kähönen, M., Järvelin, M.-R., Salomaa, V., Perola, M., Danesh, J., et al. (2021) · European Heart Journal

Lipid metabolism and disordersLipoproteins and Cardiovascular Health

Cited by 89

Associations of Adiposity, Circulating Protein Biomarkers, and Risk of Major Vascular Diseases

Pang, Y., Kartsonaki, C., Lv, J., Fairhurst-Hunter, Z., Millwood, I. Y., Yu, C., Guo, Y., Chen, Y., Bian, Z., Yang, L., et al. (2021) · JAMA Cardiology

Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and Adiposity

Cited by 75

Testing for non-linear causal effects using a binary genotype in a Mendelian randomization study: application to alcohol and cardiovascular traits

Silverwood, R. J., Holmes, M. V., Dale, C. E., Lawlor, D. A., Whittaker, J. C., Smith, G. D., Leon, D. A., Palmer, T., Keating, B. J., Zuccolo, L., et al. (2014) · International Journal of Epidemiology

Genetic Associations and EpidemiologyAdvanced Causal Inference Techniques

Cited by 66

Revealing the effect of CETP inhibition in cardiovascular disease

Holmes, M. V., & Smith, G. D. (2017) · Nature Reviews Cardiology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 56

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

Kettunen, J., Holmes, M. V., Allara, E., Anufrieva, O., Ohukainen, P., Oliver-Williams, C., Wang, Q., Tillin, T., Hughes, A. D., Kähönen, M., et al. (2019) · PLOS Biology

Lipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

Cited by 47

Utility of genetic determinants of lipids and cardiovascular events in assessing risk

Holmes, M. V., Harrison, S., Talmud, P. J., Hingorani, A. D., & Humphries, S. E. (2011) · Nature Reviews Cardiology

Lipoproteins and Cardiovascular HealthGenetic Associations and Epidemiology

Cited by 44

Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization

Zheng, J., Wheeler, E., Pietzner, M., Andlauer, T. F. M., Yau, M. S., Hartley, A. E., Brumpton, B. M., Rasheed, H., Kemp, J. P., Frysz, M., et al. (2023) · Arthritis & Rheumatology

Bone health and osteoporosis researchGenetic Associations and Epidemiology

Cited by 44

Alcohol consumption and cognitive performance: a Mendelian randomization study

Kumari, M., Holmes, M. V., Dale, C. E., Hubacek, J. A., Palmer, T. M., Pikhart, H., Peasey, A., Britton, A., Horvat, P., Kubinova, R., et al. (2014) · Addiction

Alcohol Consumption and Health EffectsGenetic Associations and Epidemiology

Cited by 31

Human Genetics and Drug Development

Holmes, M. V. (2019) · New England Journal of Medicine

Pharmacogenetics and Drug MetabolismGenetic Associations and Epidemiology

Cited by 28

Genetic variants predisposing to an increased risk of kidney stone disease

Lovegrove, C. E., Goldsworthy, M., Haley, J., Smelser, D., Gorvin, C., Hannan, F. M., Mahajan, A., Suri, M., Sadeghi-Alavijeh, O., Moochhala, S. H., et al. (2025) · Journal of Clinical Investigation

Kidney Stones and Urolithiasis TreatmentsGenetic Associations and Epidemiology

Cited by 18

Genetic variants predisposing to increased risk of kidney stone disease

Lovegrove, C. E., Goldsworthy, M., Haley, J., Diane, S., Gorvin, C., Hannan, F. M., Mahajan, A., Mohnish, S., Sadeghi-Alavijeh, O., Moochhala, S., et al. (2024) · Journal of Clinical Investigation

Kidney Stones and Urolithiasis TreatmentsGenetic Associations and Epidemiology

Cited by 18

Development and external validation of a breast cancer absolute risk prediction model in Chinese population

Han, Y., Lv, J., Yu, C., Guo, Y., Bian, Z., Hu, Y., Yang, L., Chen, Y., Du, H., Zhao, F., et al. (2021) · Breast Cancer Research

Cancer Risks and FactorsGlobal Cancer Incidence and Screening

Cited by 18