Parrott, Neil

Physiologically based pharmacokinetic modeling in drug discovery and development: A pharmaceutical industry perspective

Jones, H., Chen, Y., Gibson, C., Heimbach, T., Parrott, N., Peters, S., Snoeys, J., Upreti, V., Zheng, M., & Hall, S. (2015) · Clinical Pharmacology & Therapeutics

Pharmaceutical studies and practicesStatistical Methods in Clinical Trials

Cited by 488

A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

Jones, H. M., Parrott, N., Jorga, K., & Lav??, T. (2006) · Clinical Pharmacokinetics

Pharmaceutical studies and practicesPharmacogenetics and Drug Metabolism

Cited by 352

Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea™

Parrott, N., & Lavé, T. (2002) · European Journal of Pharmaceutical Sciences

Computational Drug Discovery MethodsDrug Solubulity and Delivery Systems

Cited by 170

Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies

Miller, N. A., Reddy, M. B., Heikkinen, A. T., Lukacova, V., & Parrott, N. (2019) · Clinical Pharmacokinetics

Pharmaceutical studies and practicesPharmacogenetics and Drug Metabolism

Cited by 142

CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor

Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Büttelmann, B., et al. (2011) · The Journal of Pharmacology and Experimental Therapeutics

Neuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Cited by 118

Challenges and opportunities with modelling and simulation in drug discovery and drug development

Lavé, T., Parrott, N., Grimm, H. P., Fleury, A., & Reddy, M. (2007) · Xenobiotica

Pharmaceutical studies and practicesStatistical Methods in Clinical Trials

Cited by 115

An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

Parrott, N., Paquereau, N., Coassolo, P., & Lavé, T. (2005) · Journal of Pharmaceutical Sciences

Computational Drug Discovery MethodsPharmacogenetics and Drug Metabolism

Cited by 107

Pharmacology of Basimglurant (RO4917523, RG7090), a Unique Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator in Clinical Development for Depression

Lindemann, L., Porter, R. H., Scharf, S. H., Kuennecke, B., Bruns, A., von Kienlin, M., Harrison, A. C., Paehler, A., Funk, C., Gloge, A., et al. (2015) · The Journal of Pharmacology and Experimental Therapeutics

Treatment of Major DepressionNeuroscience and Neuropharmacology Research

Cited by 107

Physiologically Based Absorption Modeling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Alectinib

Parrott, N. J., Yu, L. J., Takano, R., Nakamura, M., & Morcos, P. N. (2016) · The AAPS Journal

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 77

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™

Heikkinen, A. T., Baneyx, G., Caruso, A., & Parrott, N. (2012) · European Journal of Pharmaceutical Sciences

Pharmacogenetics and Drug MetabolismDrug Solubulity and Delivery Systems

Cited by 76

Food Effect Projections via Physiologically Based Pharmacokinetic Modeling: Predictive Case Studies

Tistaert, C., Heimbach, T., Xia, B., Parrott, N., Samant, T. S., & Kesisoglou, F. (2019) · Journal of Pharmaceutical Sciences

Drug Solubulity and Delivery SystemsPharmaceutical studies and practices

Cited by 75

In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

Heikkinen, A. T., Fowler, S., Gray, L., Li, J., Peng, Y., Yadava, P., Railkar, A., & Parrott, N. (2013) · Molecular Pharmaceutics

Pharmacogenetics and Drug MetabolismPharmaceutical studies and practices

Cited by 20

Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating Profiles

Ekiciler, A., Chen, W. L. K., Bo, Y., Pugliano, A., Donzelli, M., Parrott, N., & Umehara, K. (2023) · Drug Metabolism and Disposition

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 9