Rohatgi, Rajat

Patched1 Regulates Hedgehog Signaling at the Primary Cilium

Rohatgi, R., Milenkovic, L., & Scott, M. P. (2007) · Science

Hedgehog Signaling Pathway StudiesGenetic and Kidney Cyst Diseases

Cited by 1,426

Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck

Eden, S., Rohatgi, R., Podtelejnikov, A. V., Mann, M., & Kirschner, M. W. (2002) · Nature

Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions

Cited by 835

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Humke, E. W., Dorn, K. V., Milenkovic, L., Scott, M. P., & Rohatgi, R. (2010) · Genes & Development

Hedgehog Signaling Pathway StudiesGenetic and Kidney Cyst Diseases

Cited by 444

Oxysterols are allosteric activators of the oncoprotein Smoothened

Nachtergaele, S., Mydock, L. K., Krishnan, K., Rammohan, J., Schlesinger, P. H., Covey, D. F., & Rohatgi, R. (2012) · Nature Chemical Biology

Hedgehog Signaling Pathway StudiesSphingolipid Metabolism and Signaling

Cited by 284

Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium

Milenkovic, L., Scott, M. P., & Rohatgi, R. (2009) · Journal of Cell Biology

Genetic and Kidney Cyst DiseasesHedgehog Signaling Pathway Studies

Cited by 263

Gli Protein Activity Is Controlled by Multisite Phosphorylation in Vertebrate Hedgehog Signaling

Niewiadomski, P., Kong, J. H., Ahrends, R., Ma, Y., Humke, E. W., Khan, S., Teruel, M. N., Novitch, B. G., & Rohatgi, R. (2014) · Cell Reports

Hedgehog Signaling Pathway StudiesWnt/β-catenin signaling in development and cancer

Cited by 239

A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

Dorn, K. V., Hughes, C. E., & Rohatgi, R. (2012) · Developmental Cell

Hedgehog Signaling Pathway StudiesGenetic and Kidney Cyst Diseases

Cited by 174

Isolation and mutational analysis of circulating tumor cells from lung cancer patients with magnetic sifters and biochips

Earhart, C. M., Hughes, C. E., Gaster, R. S., Ooi, C. C., Wilson, R. J., Zhou, L. Y., Humke, E. W., Xu, L., Wong, D. J., Willingham, S. B., et al. (2014) · Lab Chip

Microfluidic and Bio-sensing TechnologiesMicrofluidic and Capillary Electrophoresis Applications

Cited by 165

G-protein-coupled receptors, Hedgehog signaling and primary cilia

Mukhopadhyay, S., & Rohatgi, R. (2014) · Seminars in Cell & Developmental Biology

Hedgehog Signaling Pathway StudiesGenetic and Kidney Cyst Diseases

Cited by 142

Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3′-5′ phosphodiester bonds

Rohatgi, R., Bartel, D. P., & Szostak, J. W. (1996) · Journal of the American Chemical Society

Origins and Evolution of LifeRNA and protein synthesis mechanisms

Cited by 134

G protein–coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog

Pusapati, G. V., Kong, J. H., Patel, B. B., Gouti, M., Sagner, A., Sircar, R., Luchetti, G., Ingham, P. W., Briscoe, J., & Rohatgi, R. (2018) · Science Signaling

Hedgehog Signaling Pathway StudiesReceptor Mechanisms and Signaling

Cited by 91

Direct ionic stress sensing and mitigation by the transcription factor NFAT5

Khandwala, C. B., Sarkar, P., Schmidt, H. B., Ma, M., Pusapati, G. V., Lamoliatte, F., Kinnebrew, M., Patel, B. B., Tillo, D., Lebensohn, A. M., et al. (2025) · Science Advances

Signaling Pathways in DiseaseProtein Structure and Dynamics

Cited by 11

Direct ionic stress sensing and mitigation by the transcription factor NFAT5

Khandwala, C. B., Sarkar, P., Schmidt, H. B., Ma, M., Kinnebrew, M., Pusapati, G. V., Patel, B. B., Tillo, D., Lebensohn, A. M., & Rohatgi, R. (2023) · Science Advances

Signaling Pathways in DiseaseProtein Structure and Dynamics

Cited by 11

Design principles of a membrane-spanning ubiquitin ligase

Williams, C., Nocka, L. M., Hedger, G., Parashara, P., Pardon, E., Latorraca, N. R., Pusapati, G. V., Sarkar, P., Lartey, D., Gao, L., et al. (2026) · Molecular Cell

Ubiquitin and proteasome pathwaysHedgehog Signaling Pathway Studies

Cited by 3