Takeuchi, Osamu

Pattern Recognition Receptors and Inflammation

Takeuchi, O., & Akira, S. (2010) · Cell

Immune Response and InflammationInflammasome and immune disorders

Cited by 8,895

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 6,491

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature

interferon and immune responsesImmune Response and Inflammation

Cited by 3,888

Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K., & Akira, S. (1999) · The Journal of Immunology

Immune Response and InflammationInflammasome and immune disorders

Cited by 3,374

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology

interferon and immune responsesImmune Response and Inflammation

Cited by 2,562

Cell Type-Specific Involvement of RIG-I in Antiviral Response

Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., et al. (2005) · Immunity

interferon and immune responsesImmune Response and Inflammation

Cited by 1,368

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., et al. (2010) · Nature Immunology

Immune cells in cancerParasites and Host Interactions

Cited by 1,156

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

Saitoh, T., Fujita, N., Hayashi, T., Takahara, K., Satoh, T., Lee, H., Matsunaga, K., Kageyama, S., Omori, H., Noda, T., et al. (2009) · Proceedings of the National Academy of Sciences

interferon and immune responsesImmune Response and Inflammation

Cited by 854

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

Schinzel, A. C., Takeuchi, O., Huang, Z., Fisher, J. K., Zhou, Z., Rubens, J., Hetz, C., Danial, N. N., Moskowitz, M. A., & Korsmeyer, S. J. (2005) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyCell death mechanisms and regulation

Cited by 820

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

Kim, H., Tu, H.-C., Ren, D., Takeuchi, O., Jeffers, J. R., Zambetti, G. P., Hsieh, J. J.-D., & Cheng, E. H.-Y. (2009) · Molecular Cell

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 600

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

Mino, T., Murakawa, Y., Fukao, A., Vandenbon, A., Wessels, H.-H., Ori, D., Uehata, T., Tartey, S., Akira, S., Suzuki, Y., et al. (2015) · Cell

RNA Research and SplicingRNA regulation and disease

Cited by 390

Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo

Masuda, K., Ripley, B., Nishimura, R., Mino, T., Takeuchi, O., Shioi, G., Kiyonari, H., & Kishimoto, T. (2013) · Proceedings of the National Academy of Sciences

RNA Research and SplicingCytokine Signaling Pathways and Interactions

Cited by 226

Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways.

Henneke, P., Takeuchi, O., Malley, R., Lien, E., Ingalls, R. R., Freeman, M. W., Mayadas, T., Nizet, V., Akira, S., Kasper, D. L., et al. (2002) · The Journal of Immunology

Immune Response and InflammationNeonatal and Maternal Infections

Cited by 145

Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β

Hirotani, T., Yamamoto, M., Kumagai, Y., Uematsu, S., Kawase, I., Takeuchi, O., & Akira, S. (2005) · Biochemical and Biophysical Research Communications

Immune Response and InflammationInflammasome and immune disorders

Cited by 135

Poly I:C-Induced Activation of NK Cells by CD8α+ Dendritic Cells via the IPS-1 and TRIF-Dependent Pathways

Miyake, T., Kumagai, Y., Kato, H., Guo, Z., Matsushita, K., Satoh, T., Kawagoe, T., Kumar, H., Jang, M. H., Kawai, T., et al. (2009) · The Journal of Immunology

Immune Cell Function and Interactioninterferon and immune responses

Cited by 115

Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages

Shiratsuchi, A., Watanabe, I., Takeuchi, O., Akira, S., & Nakanishi, Y. (2004) · The Journal of Immunology

Phagocytosis and Immune RegulationImmune Response and Inflammation

Cited by 112

Mouse proteasomal ATPases Psmc3 and Psmc4: genomic organization and gene targeting.

Sakao, Y., Kawai, T., Takeuchi, O., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Takeda, K., & Akira, S. (2000) · Genomics

Ubiquitin and proteasome pathwaysHeat shock proteins research

Cited by 50