Owen, David R.

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., et al. (2021) · The Lancet

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 4,616

Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials

Voysey, M., Costa Clemens, S. A., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., et al. (2021) · The Lancet

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 1,119

An 18-kDa translocator protein (TSPO) polymorphism explains differences in binding affinity of the PET radioligand PBR28

Owen, D. R., Yeo, A. J., Gunn, R. N., Song, K., Wadsworth, G., Lewis, A., Rhodes, C., Pulford, D. J., Bennacef, I., Parker, C. A., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism

Neuroinflammation and Neurodegeneration MechanismsPharmacological Receptor Mechanisms and Effects

Cited by 779

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology

Smith, A. M., Davey, K., Tsartsalis, S., Khozoie, C., Fancy, N., Tang, S. S., Liaptsi, E., Weinert, M., McGarry, A., Muirhead, R. C. J., et al. (2022) · Acta Neuropathologica

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 209

Pro-inflammatory activation of primary microglia and macrophages increases 18 kDa translocator protein expression in rodents but not humans

Owen, D. R., Narayan, N., Wells, L., Healy, L., Smyth, E., Rabiner, E. A., Galloway, D., Williams, J. B., Lehr, J., Mandhair, H., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism

Neuroinflammation and Neurodegeneration MechanismsPharmacological Receptor Mechanisms and Effects

Cited by 194

Cellular sources of TSPO expression in healthy and diseased brain

Nutma, E., Ceyzériat, K., Amor, S., Tsartsalis, S., Millet, P., Owen, D. R., Papadopoulos, V., & Tournier, B. B. (2021) · European Journal of Nuclear Medicine and Molecular Imaging

Neuroinflammation and Neurodegeneration MechanismsPharmacological Receptor Mechanisms and Effects

Cited by 192

Safety and immunogenicity of a self-amplifying RNA vaccine against COVID-19: COVAC1, a phase I, dose-ranging trial

Pollock, K. M., Cheeseman, H. M., Szubert, A. J., Libri, V., Boffito, M., Owen, D., Bern, H., McFarlane, L. R., O'Hara, J., Lemm, N.-M., et al. (2022) · eClinicalMedicine

SARS-CoV-2 and COVID-19 ResearchRNA Interference and Gene Delivery

Cited by 173

A quantitative neuropathological assessment of translocator protein expression in multiple sclerosis

Nutma, E., Stephenson, J. A., Gorter, R. P., de Bruin, J., Boucherie, D. M., Donat, C. K., Breur, M., van der Valk, P., Matthews, P. M., Owen, D. R., et al. (2019) · Brain

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 138

In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with18F-PBR111 PET

Colasanti, A., Guo, Q., Muhlert, N., Giannetti, P., Onega, M., Newbould, R. D., Ciccarelli, O., Rison, S., Thomas, C., Nicholas, R., et al. (2014) · Journal of Nuclear Medicine

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 100

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer’s disease

Tsartsalis, S., Sleven, H., Fancy, N., Wessely, F., Smith, A. M., Willumsen, N., Cheung, T. K. D., Rokicki, M. J., Chau, V., Ifie, E., et al. (2024) · Nature Communications

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 95

The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory ‘M1’ human macrophages

Narayan, N., Mandhair, H., Smyth, E., Dakin, S. G., Kiriakidis, S., Wells, L., Owen, D., Sabokbar, A., & Taylor, P. (2017) · PLOS ONE

Immune cells in cancerNeuroinflammation and Neurodegeneration Mechanisms

Cited by 79

Bipolar Disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa Translocator Protein (TSPO)

Colasanti, A., Owen, D. R., Grozeva, D., Rabiner, E. A., Matthews, P. M., Craddock, N., & Young, A. H. (2013) · Psychoneuroendocrinology

Bipolar Disorder and TreatmentGenetic Associations and Epidemiology

Cited by 55

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

The LOVIT-COVID Investigators, O. B. O. T. C. C. C. T. G., Florescu, S., Stanciu, D., Zaharia, M., Kosa, A., Codreanu, D., Fareed, K., Kidwai, A., Kaye, C., Coutts, A., et al. (2023) · JAMA

Vitamin C and Antioxidants ResearchCOVID-19 Clinical Research Studies

Cited by 55

Alzheimer’s disease-related transcriptional sex differences in myeloid cells

Coales, I., Tsartsalis, S., Fancy, N., Weinert, M., Clode, D., Owen, D., & Matthews, P. M. (2022) · Journal of Neuroinflammation

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 49

Characteristics of TSPO expression in marmoset EAE

Falk, I., Maric, D., Leibovitch, E., Sati, P., Lefeuvre, J., Luciano, N. J., Guy, J., Ha, S.-K., Owen, D. R., Aigbirhio, F., et al. (2025) · Journal of Neuroinflammation

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 5