Velten, Lars

Human haematopoietic stem cell lineage commitment is a continuous process

Velten, L., Haas, S. F., Raffel, S., Blaszkiewicz, S., Islam, S., Hennig, B. P., Hirche, C., Lutz, C., Buss, E. C., Nowak, D., et al. (2017) · Nature Cell Biology

Hematopoietic Stem Cell TransplantationSingle-cell and spatial transcriptomics

Cited by 925

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors

Haas, S., Hansson, J., Klimmeck, D., Loeffler, D., Velten, L., Uckelmann, H., Wurzer, S., Prendergast, Á. M., Schnell, A., Hexel, K., et al. (2015) · Cell Stem Cell

Platelet Disorders and TreatmentsHematopoietic Stem Cell Transplantation

Cited by 471

Deciphering the rules by which 5′-UTR sequences affect protein expression in yeast

Dvir, S., Velten, L., Sharon, E., Zeevi, D., Carey, L. B., Weinberger, A., & Segal, E. (2013) · Proceedings of the National Academy of Sciences

RNA and protein synthesis mechanismsRNA Research and Splicing

Cited by 246

Targeted Perturb-seq enables genome-scale genetic screens in single cells

Schraivogel, D., Gschwind, A. R., Milbank, J. H., Leonce, D. R., Jakob, P., Mathur, L., Korbel, J. O., Merten, C. A., Velten, L., & Steinmetz, L. M. (2020) · Nature Methods

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 245

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

Young, K., Eudy, E., Bell, R., Loberg, M. A., Stearns, T., Sharma, D., Velten, L., Haas, S., Filippi, M.-D., & Trowbridge, J. J. (2021) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationGenetics, Aging, and Longevity in Model Organisms

Cited by 216

Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states

Triana, S., Vonficht, D., Jopp-Saile, L., Raffel, S., Lutz, R., Leonce, D., Antes, M., Hernández-Malmierca, P., Ordoñez-Rueda, D., Ramasz, B., et al. (2021) · Nature Immunology

Single-cell and spatial transcriptomicsAdvanced Proteomics Techniques and Applications

Cited by 195

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

Beneyto-Calabuig, S., Merbach, A. K., Kniffka, J.-A., Antes, M., Szu-Tu, C., Rohde, C., Waclawiczek, A., Stelmach, P., Gräßle, S., Pervan, P., et al. (2023) · Cell Stem Cell

Acute Myeloid Leukemia ResearchSingle-cell and spatial transcriptomics

Cited by 96

Design principles of cell-state-specific enhancers in hematopoiesis

Frömel, R., Rühle, J., Bernal Martinez, A., Szu-Tu, C., Pacheco Pastor, F., Martinez-Corral, R., & Velten, L. (2025) · Cell

Genomics and Chromatin DynamicsGene Regulatory Network Analysis

Cited by 29

Emergence of activation or repression in transcriptional control under a fixed molecular context

Martinez-Corral, R., Friedrich, D., Frömel, R., Velten, L., Gunawardena, J., & DePace, A. H. (2024) · Proceedings of the National Academy of Sciences

Gene Regulatory Network AnalysisGenomics and Chromatin Dynamics

Cited by 18