Tenen, Daniel G.

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

Kirstetter, P., Schuster, M. B., Bereshchenko, O., Moore, S., Dvinge, H., Kurz, E., Theilgaard-Mönch, K., Månsson, R., Pedersen, T. Å., Pabst, T., et al. (2008) · Cancer Cell

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 251

The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia

Vangala, R. K., Heiss-Neumann, M. S., Rangatia, J. S., Singh, S. M., Schoch, C., Tenen, D. G., Hiddemann, W., & Behre, G. (2003) · Blood

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 245

Heterozygous PU.1 mutations are associated with acute myeloid leukemia

Mueller, B. U., Pabst, T., Osato, M., Asou, N., Johansen, L. M., Minden, M. D., Behre, G., Hiddemann, W., Ito, Y., & Tenen, D. G. (2002) · Blood

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 243

Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1

Rosenbauer, F., Owens, B. M., Yu, L., Tumang, J. R., Steidl, U., Kutok, J. L., Clayton, L. K., Wagner, K., Scheller, M., Iwasaki, H., et al. (2006) · Nature Genetics

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 237

Multiple Functional Domains of AML1: PU.1 and C/EBPα Synergize with Different Regions of AML1

Petrovick, M. S., Hiebert, S. W., Friedman, A. D., Hetherington, C. J., Tenen, D. G., & Zhang, D.-E. (1998) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 218

ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

Mueller, B. U., Pabst, T., Fos, J., Petkovic, V., Fey, M. F., Asou, N., Buergi, U., & Tenen, D. G. (2006) · Blood

Retinoids in leukemia and cellular processesAcute Myeloid Leukemia Research

Cited by 207

APOE4 impairs the microglial response in Alzheimer’s disease by inducing TGFβ-mediated checkpoints

Yin, Z., Rosenzweig, N., Kleemann, K. L., Zhang, X., Brandão, W., Margeta, M. A., Schroeder, C., Sivanathan, K. N., Silveira, S., Gauthier, C., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 202

Identification of a Region Which Directs the Monocytic Activity of the Colony-Stimulating Factor 1 (Macrophage Colony-Stimulating Factor) Receptor Promoter and Binds PEBP2/CBF (AML1)

Zhang, D.-E., Fujioka, K.-I., Hetherington, C. J., Shapiro, L. H., Chen, H.-M., Look, A. T., & Tenen, D. G. (1994) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsCytokine Signaling Pathways and Interactions

Cited by 199

The Sp1 transcription factor binds the CD11b promoter specifically in myeloid cells in vivo and is essential for myeloid-specific promoter activity.

Chen, H. M., Pahl, H. L., Scheibe, R. J., Zhang, D. E., & Tenen, D. G. (1993) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsCell Adhesion Molecules Research

Cited by 199

PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

Olson, M. C., Scott, E. W., Hack, A. A., Su, G. H., Tenen, D. G., Singh, H., & Simon, M. C. (1995) · Immunity

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 191

Essential role of Jun family transcription factors in PU.1 knockdown–induced leukemic stem cells

Steidl, U., Rosenbauer, F., Verhaak, R. G. W., Gu, X., Ebralidze, A., Otu, H. H., Klippel, S., Steidl, C., Bruns, I., Costa, D. B., et al. (2006) · Nature Genetics

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 184

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

Ptasinska, A., Assi, S. A., Mannari, D., James, S. R., Williamson, D., Dunne, J., Hoogenkamp, M., Wu, M., Care, M., McNeill, H., et al. (2012) · Leukemia

Acute Myeloid Leukemia ResearchChromatin Remodeling and Cancer

Cited by 184

Defective B cell receptor‐mediated responses in mice lacking the Ets protein, Spi‐B

Su, G. H., Chen, H., Muthusamy, N., Garrett‐Sinha, L. A., Baunoch, D., Tenen, D. G., & Simon, M. C. (1997) · The EMBO Journal

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 182

CCAAT/enhancer binding protein ɛ is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing

Yamanaka, R., Kim, G.-D., Radomska, H. S., Lekstrom-Himes, J., Smith, L. T., Antonson, P., Tenen, D. G., & Xanthopoulos, K. G. (1997) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsRetinoids in leukemia and cellular processes

Cited by 180

c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

Behre, G., Whitmarsh, A. J., Coghlan, M. P., Hoang, T., Carpenter, C. L., Zhang, D.-E., Davis, R. J., & Tenen, D. G. (1999) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsCytokine Signaling Pathways and Interactions

Cited by 180

Potential Autoregulation of Transcription Factor PU.1 by an Upstream Regulatory Element

Okuno, Y., Huang, G., Rosenbauer, F., Evans, E. K., Radomska, H. S., Iwasaki, H., Akashi, K., Moreau-Gachelin, F., Li, Y., Zhang, P., et al. (2005) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 174

Effects of Erlotinib in EGFR Mutated Non-Small Cell Lung Cancers with Resistance to Gefitinib

Costa, D. B., Nguyen, K.-S. H., Cho, B. C., Sequist, L. V., Jackman, D. M., Riely, G. J., Yeap, B. Y., Halmos, B., Kim, J. H., Jänne, P. A., et al. (2008) · Clinical Cancer Research

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 171

Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells

Cheng, T., Shen, H., Giokas, D., Gere, J., Tenen, D. G., & Scadden, D. T. (1996) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 163

Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers

Costa, D. B., Kobayashi, S., Tenen, D. G., & Huberman, M. S. (2007) · Lung Cancer

Lung Cancer Treatments and MutationsLung Cancer Diagnosis and Treatment

Cited by 160

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

Staber, P. B., Zhang, P., Ye, M., Welner, R. S., Nombela-Arrieta, C., Bach, C., Kerenyi, M., Bartholdy, B. A., Zhang, H., Alberich-Jordà, M., et al. (2013) · Molecular Cell

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 158

Granulocyte inducer C/EBPα inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions

Reddy, V. A., Iwama, A., Iotzova, G., Schulz, M., Elsasser, A., Vangala, R. K., Tenen, D. G., Hiddemann, W., & Behre, G. (2002) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 152

Inhibition of hematopoiesis by competitive binding of transcription factor PU.1

Voso, M. T., Burn, T. C., Wulf, G., Lim, B., Leone, G., & Tenen, D. G. (1994) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationGenomics and Chromatin Dynamics

Cited by 141

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia

Gerloff, D., Grundler, R., Wurm, A. A., Bräuer-Hartmann, D., Katzerke, C., Hartmann, J.-U., Madan, V, Müller-Tidow, C., Duyster, J., Tenen, D. G., et al. (2015) · Leukemia

Acute Myeloid Leukemia ResearchMicroRNA in disease regulation

Cited by 135

Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b

Suzuki, M., Yamada, T., Kihara-Negishi, F., Sakurai, T., Hara, E., Tenen, D. G., Hozumi, N., & Oikawa, T. (2006) · Oncogene

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 132