Tenen, Daniel G.

EGFR Mutation and Resistance of Non–Small-Cell Lung Cancer to Gefitinib

Kobayashi, S., Boggon, T. J., Dayaram, T., Jänne, P. A., Kocher, O., Meyerson, M., Johnson, B. E., Eck, M. J., Tenen, D. G., & Halmos, B. (2005) · New England Journal of Medicine

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 3,964

Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak

Dai, M., Liu, D., Liu, M., Zhou, F., Li, G., Chen, Z., Zhang, Z., You, H., Wu, M., Zheng, Q., et al. (2020) · Cancer Discovery

COVID-19 and healthcare impactsCOVID-19 Clinical Research Studies

Cited by 1,589

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice

Zhang, D.-E., Zhang, P., Wang, N.-D., Hetherington, C. J., Darlington, G. J., & Tenen, D. G. (1997) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchBlood disorders and treatments

Cited by 910

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

Pabst, T., Mueller, B. U., Zhang, P., Radomska, H. S., Narravula, S., Schnittger, S., Behre, G., Hiddemann, W., & Tenen, D. G. (2001) · Nature Genetics

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 901

Transcription Factors, Normal Myeloid Development, and Leukemia

Tenen, D. G., Hromas, R., Licht, J. D., & Zhang, D.-E. (1997) · Blood

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 735

Disruption of differentiation in human cancer: AML shows the way

Tenen, D. G. (2003) · Nature Reviews Cancer

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 612

Transcription factors in myeloid development: balancing differentiation with transformation

Rosenbauer, F., & Tenen, D. G. (2007) · Nature Reviews Immunology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 606

Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1.

Rosenbauer, F., Wagner, K., Kutok, J. L., Iwasaki, H., Le Beau, M. M., Okuno, Y., Akashi, K., Fiering, S., & Tenen, D. G. (2004) · Nature Genetics

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 506

CCAAT/Enhancer Binding Protein α Is a Regulatory Switch Sufficient for Induction of Granulocytic Development from Bipotential Myeloid Progenitors

Radomska, H. S., Huettner, C. S., Zhang, P., Cheng, T., Scadden, D. T., & Tenen, D. G. (1998) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 466

AML1–ETO downregulates the granulocytic differentiation factor C/EBPα in t(8;21) myeloid leukemia

Pabst, T., Mueller, B. U., Harakawa, N., Schoch, C., Haferlach, T., Behre, G., Hiddemann, W., Zhang, D.-E., & Tenen, D. G. (2001) · Nature Medicine

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 463

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

Ji, H., Li, D., Chen, L., Shimamura, T., Kobayashi, S., McNamara, K., Mahmood, U., Mitchell, A., Sun, Y., Al-Hashem, R., et al. (2006) · Cancer Cell

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 462

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

Zhang, P., Behre, G., Pan, J., Iwama, A., Wara-aswapati, N., Radomska, H. S., Auron, P. E., Tenen, D. G., & Sun, Z. (1999) · Proceedings of the National Academy of Sciences

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 459

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation

Iwasaki, H., Somoza, C., Shigematsu, H., Duprez, E. A., Iwasaki-Arai, J., Mizuno, S.-I., Arinobu, Y., Geary, K., Zhang, P., Dayaram, T., et al. (2005) · Blood

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 433

C/EBPβ is required for 'emergency' granulopoiesis

Hirai, H., Zhang, P., Dayaram, T., Hetherington, C. J., Mizuno, S.-I., Imanishi, J., Akashi, K., & Tenen, D. G. (2006) · Nature Immunology

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

Cited by 425

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

Zhang, D.-E., Hetherington, C. J., Chen, H.-M., & Tenen, D. G. (1994) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsImmune cells in cancer

Cited by 411

CCAAT Enhancer-Binding Protein (C/EBP) and AML1 (CBFα2) Synergistically Activate the Macrophage Colony-Stimulating Factor Receptor Promoter

Zhang, D.-E., Hetherington, C. J., Meyers, S., Rhoades, K. L., Larson, C. J., Chen, H.-M., Hiebert, S. W., & Tenen, D. G. (1996) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 396

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

Zhang, P., Zhang, X., Iwama, A., Yu, C., Smith, K. A., Mueller, B. U., Narravula, S., Torbett, B. E., Orkin, S. H., & Tenen, D. G. (2000) · Blood

Genomics and Chromatin DynamicsHemoglobinopathies and Related Disorders

Cited by 368

Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene

Yergeau, D. A., Hetherington, C. J., Wang, Q., Zhang, P., Sharpe, A. H., Binder, M., Marín-Padilla, M., Tenen, D. G., Speck, N. A., & Zhang, D.-E. (1997) · Nature Genetics

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 346

The proto-oncogene PU.1 regulates expression of the myeloid-specific CD11b promoter

Pahl, H. L., Scheibe, R. J., Zhang, D. E., Chen, H. M., Galson, D. L., Maki, R. A., & Tenen, D. G. (1993) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsCell Adhesion Molecules Research

Cited by 301

PU.1 (Spi-1) and C/EBPα Regulate Expression of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor α Gene

Hohaus, S., Petrovick, M. S., Voso, M. T., Sun, Z., Zhang, D.-E., & Tenen, D. G. (1995) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsCytokine Signaling Pathways and Interactions

Cited by 284

An Alternative Inhibitor Overcomes Resistance Caused by a Mutation of the Epidermal Growth Factor Receptor

Kobayashi, S., Ji, H., Yuza, Y., Meyerson, M., Wong, K.-K., Tenen, D. G., & Halmos, B. (2005) · Cancer Research

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer Research

Cited by 272

c-Myc Is a Critical Target for C/EBPα in Granulopoiesis

Johansen, L. M., Iwama, A., Lodie, T. A., Sasaki, K., Felsher, D. W., Golub, T. R., & Tenen, D. G. (2001) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 263

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Huang, G., Zhang, P., Hirai, H., Elf, S., Yan, X., Chen, Z., Koschmieder, S., Okuno, Y., Dayaram, T., Growney, J. D., et al. (2008) · Nature Genetics

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 259

Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma

Yong, K. J., Gao, C., Lim, J. S. J., Yan, B., Yang, H., Dimitrov, T., Kawasaki, A., Ong, C. W., Wong, K.-F., Lee, S., et al. (2013) · New England Journal of Medicine

Hepatocellular Carcinoma Treatment and PrognosisLiver physiology and pathology

Cited by 257