Tenen, Daniel G.

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells

Leddin, M., Perrod, C., Hoogenkamp, M., Ghani, S., Assi, S., Heinz, S., Wilson, N. K., Follows, G., Schönheit, J., Vockentanz, L., et al. (2011) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 131

SALL4, the missing link between stem cells, development and cancer

Tatetsu, H., Kong, N. R., Chong, G., Amabile, G., Tenen, D. G., & Chai, L. (2016) · Gene

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 130

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein α (C/EBPα) Is Critical for Granulopoiesis

Zhang, P., Iwama, A., Datta, M. W., Darlington, G. J., Link, D. C., & Tenen, D. G. (1998) · The Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsHematopoietic Stem Cell Transplantation

Cited by 130

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.

Rhoades, K. L., Hetherington, C. J., Rowley, J. D., Hiebert, S. W., Nucifora, G., Tenen, D. G., & Zhang, D. E. (1996) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 129

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

Guibal, F. C., Alberich-Jorda, M., Hirai, H., Ebralidze, A., Levantini, E., Di Ruscio, A., Zhang, P., Santana-Lemos, B. A., Neuberg, D., Wagers, A. J., et al. (2009) · Blood

Retinoids in leukemia and cellular processesAcute Myeloid Leukemia Research

Cited by 126

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program

Hoogenkamp, M., Lichtinger, M., Krysinska, H., Lancrin, C., Clarke, D., Williamson, A., Mazzarella, L., Ingram, R., Jorgensen, H., Fisher, A., et al. (2009) · Blood

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 121

C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

Yeamans, C., Wang, D., Paz-Priel, I., Torbett, B. E., Tenen, D. G., & Friedman, A. D. (2007) · Blood

Genomics and Chromatin DynamicsAcute Myeloid Leukemia Research

Cited by 118

A distal single nucleotide polymorphism alters long-range regulation of the PU.1 gene in acute myeloid leukemia

Steidl, U., Steidl, C., Ebralidze, A., Chapuy, B., Han, H.-J., Will, B., Rosenbauer, F., Becker, A., Wagner, K., Koschmieder, S., et al. (2007) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 114

Regulation of the PU.1 gene by distal elements

Li, Y., Okuno, Y., Zhang, P., Radomska, H. S., Chen, H.-M., Iwasaki, H., Akashi, K., Klemsz, M. J., McKercher, S. R., Maki, R. A., et al. (2001) · Blood

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 110

PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2

Aikawa, Y., Katsumoto, T., Zhang, P., Shima, H., Shino, M., Terui, K., Ito, E., Ohno, H., Stanley, E. R., Singh, H., et al. (2010) · Nature Medicine

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 96

Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBP

Iwama, A., Zhang, P., Darlington, G. J., McKercher, S. R., Maki, R., & Tenen, D. G. (1998) · Nucleic Acids Research

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

Cited by 91

Super-enhancers and broad H3K4me3 domains form complex gene regulatory circuits involving chromatin interactions

Cao, F., Fang, Y., Tan, H. K., Goh, Y., Choy, J. Y. H., Koh, B. T. H., Hao Tan, J., Bertin, N., Ramadass, A., Hunter, E., et al. (2017) · Scientific Reports

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 80

ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

Zhou, Q., Yu, M., Tirado-Magallanes, R., Li, B., Kong, L., Guo, M., Tan, Z. H., Lee, S., Chai, L., Numata, A., et al. (2021) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 79

Use of a Promoterless Renilla Luciferase Vector as an Internal Control Plasmid for Transient Co-Transfection Assays of Ras -Mediated Transcription Activation

Behre, G., Smith, L. T., & Tenen, D. G. (1999) · BioTechniques

Protein Kinase Regulation and GTPase Signalingbioluminescence and chemiluminescence research

Cited by 75

Role of Transcription Factors C/EBPa and PU.1 in Normal Hematopoiesis and Leukemia

Koschmieder, S., Rosenbauer, F., Steidl, U., Owens, B. M., & Tenen, D. G. (2005) · International Journal of Hematology

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 72

Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα

Radomska, H. S., Alberich-Jordà, M., Will, B., Gonzalez, D., Delwel, R., & Tenen, D. G. (2012) · Journal of Clinical Investigation

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 67

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Liu, B. H., Jobichen, C., Chia, C. S. B., Chan, T. H. M., Tang, J. P., Chung, T. X. Y., Li, J., Poulsen, A., Hung, A. W., Koh-Stenta, X., et al. (2018) · Proceedings of the National Academy of Sciences

Chromatin Remodeling and CancerChemical Synthesis and Analysis

Cited by 67

Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancy

Wagner, K., Zhang, P., Rosenbauer, F., Drescher, B., Kobayashi, S., Radomska, H. S., Kutok, J. L., Gilliland, D. G., Krauter, J., & Tenen, D. G. (2006) · Proceedings of the National Academy of Sciences

Acute Myeloid Leukemia ResearchChronic Myeloid Leukemia Treatments

Cited by 66

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex

Gao, C., Dimitrov, T., Yong, K. J., Tatetsu, H., Jeong, H.-W., Luo, H. R., Bradner, J. E., Tenen, D. G., & Chai, L. (2013) · Blood

Acute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors Research

Cited by 65

Downregulation of c-Jun Expression by Transcription Factor C/EBPα Is Critical for Granulocytic Lineage Commitment

Rangatia, J., Vangala, R. K., Treiber, N., Zhang, P., Radomska, H., Tenen, D. G., Hiddemann, W., & Behre, G. (2002) · Molecular and Cellular Biology

Genomics and Chromatin DynamicsRetinoids in leukemia and cellular processes

Cited by 62

Elevated c-Jun expression in acute myeloid leukemias inhibits C/EBPα DNA binding via leucine zipper domain interaction

Rangatia, J., Vangala, R. K., Singh, S. M., Peer Zada, A. A., Elsässer, A., Kohlmann, A., Haferlach, T., Tenen, D. G., Hiddemann, W., & Behre, G. (2003) · Oncogene

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 62

Octamer Binding Factors and Their Coactivator Can Activate the Murine PU.1 (spi-1) Promoter

Chen, H.-M., Zhang, P., Radomska, H. S., Hetherington, C. J., Zhang, D.-E., & Tenen, D. G. (1996) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsT-cell and B-cell Immunology

Cited by 59

SALL4 is a key transcription regulator in normal human hematopoiesis

Gao, C., Kong, N. R., Li, A., Tatetu, H., Ueno, S., Yang, Y., He, J., Yang, J., Ma, Y., Kao, G. S., et al. (2013) · Transfusion

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 58

Chronic interleukin-1 exposure triggers selection for Cebpa -knockout multipotent hematopoietic progenitors

Higa, K. C., Goodspeed, A., Chavez, J. S., De Dominici, M., Danis, E., Zaberezhnyy, V., Rabe, J. L., Tenen, D. G., Pietras, E. M., & DeGregori, J. (2021) · Journal of Experimental Medicine

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 57