Keane, Thomas M.

Mouse genomic variation and its effect on phenotypes and gene regulation.

Keane, T. M., Goodstadt, L., Danecek, P., White, M. A., Wong, K., Yalcin, B., Heger, A., Agam, A., Slater, G., Goodson, M., et al. (2011) · Nature

Genetic Mapping and Diversity in Plants and AnimalsGenetic and phenotypic traits in livestock

Cited by 1,580

The UK10K project identifies rare variants in health and disease

The UK10K Consortium, Writing group, Walter, K., Min, J. L., Huang, J., Crooks, L., Memari, Y., McCarthy, S., Perry, J. R. B., Xu, C., et al. (2015) · Nature

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 1,040

A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains

Simon, M. M., Greenaway, S., White, J. K., Fuchs, H., Gailus-Durner, V., Wells, S., Sorg, T., Wong, K., Bedu, E., Cartwright, E. J., et al. (2013) · Genome Biology

Genetic and phenotypic traits in livestockGenetic Mapping and Diversity in Plants and Animals

Cited by 507

Assessing the gene space in draft genomes

Parra, G., Bradnam, K., Ning, Z., Keane, T., & Korf, I. (2009) · Nucleic Acids Research

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 395

POT1 loss-of-function variants predispose to familial melanoma

Robles-Espinoza, C. D., Harland, M., Ramsay, A. J., Aoude, L. G., Quesada, V., Ding, Z., Pooley, K. A., Pritchard, A. L., Tiffen, J. C., Petljak, M., et al. (2014) · Nature Genetics

Telomeres, Telomerase, and SenescenceCutaneous Melanoma Detection and Management

Cited by 391

Sequence-based characterization of structural variation in the mouse genome

Yalcin, B., Wong, K., Agam, A., Goodson, M., Keane, T. M., Gan, X., Nellåker, C., Goodstadt, L., Nicod, J., Bhomra, A., et al. (2011) · Nature

Genomic variations and chromosomal abnormalitiesGenome Rearrangement Algorithms

Cited by 301

Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci

Lilue, J., Doran, A. G., Fiddes, I. T., Abrudan, M., Armstrong, J., Bennett, R., Chow, W., Collins, J., Collins, S., Czechanski, A., et al. (2018) · Nature Genetics

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 267

Off-target mutations are rare in Cas9-modified mice

Iyer, V., Shen, B., Zhang, W., Hodgkins, A., Keane, T., Huang, X., & Skarnes, W. C. (2015) · Nature Methods

CRISPR and Genetic EngineeringAnimal Genetics and Reproduction

Cited by 185

Comparative Annotation Toolkit (CAT)—simultaneous clade and personal genome annotation

Fiddes, I. T., Armstrong, J., Diekhans, M., Nachtweide, S., Kronenberg, Z. N., Underwood, J. G., Gordon, D., Earl, D., Keane, T., Eichler, E. E., et al. (2018) · Genome Research

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 120

Whole-genome sequence-based analysis of thyroid function

Taylor, P. N., Porcu, E., Chew, S., Campbell, P. J., Traglia, M., Brown, S. J., Mullin, B. H., Shihab, H. A., Min, J., Walter, K., et al. (2015) · Nature Communications

Genetic Associations and EpidemiologyThyroid Disorders and Treatments

Cited by 104

Deep genome sequencing and variation analysis of 13 inbred mouse strains defines candidate phenotypic alleles, private variation and homozygous truncating mutations

Doran, A. G., Wong, K., Flint, J., Adams, D. J., Hunter, K. W., & Keane, T. M. (2016) · Genome Biology

Genomics and Phylogenetic StudiesGenetic and phenotypic traits in livestock

Cited by 101

Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells

Forment, J. V., Herzog, M., Coates, J., Konopka, T., Gapp, B. V., Nijman, S. M., Adams, D. J., Keane, T. M., & Jackson, S. P. (2017) · Nature Chemical Biology

CRISPR and Genetic EngineeringPlant Genetic and Mutation Studies

Cited by 40

Mouse protein coding diversity: What’s left to discover?

Lilue, J., Shivalikanjli, A., Adams, D. J., & Keane, T. M. (2019) · PLOS Genetics

Genomics and Phylogenetic StudiesGenetic Mapping and Diversity in Plants and Animals

Cited by 19

The structural diversity of telomeres and centromeres across mouse subspecies revealed by complete assemblies

Francis, B., Gozashti, L., Costello, K., Kasahara, T., Harringmeyer, O. S., Lilue, J., Helmy, M., Kato, T., Czechanski, A., Quail, M., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory)

Chromosomal and Genetic VariationsGenomics and Phylogenetic Studies

Cited by 8

IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway

Moran, E. A., Salas-Briceno, K., Zhao, W., Enya, T., Aguilera, A. N., Acosta, I., Alonzo, F., Kiani, D., Behnsen, J., Alvarez, C., et al. (2024) · mBio

interferon and immune responsesImmune Response and Inflammation

Cited by 4

High-quality mouse reference genomes reveal the structural complexity of the murine protein-coding landscape

Helmy, M., Li, J. U., Yan, X. F., Meade, R. K., Anderson, E., Chen, P. B., Czechanski, A. M., Di Domenico, T., Flint, J., Garrison, E., et al. (2026) · Cell Genomics

Genomics and Phylogenetic StudiesChromosomal and Genetic Variations

Cited by 2