Riggins, Gregory J.

Mutations of the BRAF gene in human cancer

Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., et al. (2002) · Nature

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 10,674

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

Parsons, D. W., Jones, S., Zhang, X., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Siu, I.-M., Gallia, G. L., et al. (2008) · Science

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 5,857

IDH1 and IDH2 Mutations in Gliomas

Yan, H., Parsons, D. W., Jin, G., McLendon, R., Rasheed, B. A., Yuan, W., Kos, I., Batinic-Haberle, I., Jones, S., Riggins, G. J., et al. (2009) · New England Journal of Medicine

Glioma Diagnosis and TreatmentCancer, Hypoxia, and Metabolism

Cited by 5,847

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Bettegowda, C., Sausen, M., Leary, R. J., Kinde, I., Wang, Y., Agrawal, N., Bartlett, B. R., Wang, H., Luber, B., Alani, R. M., et al. (2014) · Science Translational Medicine

Cancer Genomics and DiagnosticsPrenatal Screening and Diagnostics

Cited by 5,067

Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome

Verkerk, A. J. M. H., Pieretti, M., Sutcliffe, J. S., Fu, Y.-H., Kuhl, D. P. A., Pizzuti, A., Reiner, O., Richards, S., Victoria, M. F., Zhang, F., et al. (1991) · Cell

Genetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities

Cited by 3,481

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., et al. (2013) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceCancer-related molecular mechanisms research

Cited by 1,368

Altered Telomeres in Tumors with ATRX and DAXX Mutations

Heaphy, C. M., de Wilde, R. F., Jiao, Y., Klein, A. P., Edil, B. H., Shi, C., Bettegowda, C., Rodriguez, F. J., Eberhart, C. G., Hebbar, S., et al. (2011) · Science

Telomeres, Telomerase, and SenescenceChromatin Remodeling and Cancer

Cited by 1,083

Proteogenomic and metabolomic characterization of human glioblastoma

Wang, L.-B., Karpova, A., Gritsenko, M. A., Kyle, J. E., Cao, S., Li, Y., Rykunov, D., Colaprico, A., Rothstein, J. H., Hong, R., et al. (2021) · Cancer Cell

Glioma Diagnosis and TreatmentCancer Genomics and Diagnostics

Cited by 661

Intratumoral injection of Clostridium novyi -NT spores induces antitumor responses

Roberts, N. J., Zhang, L., Janku, F., Collins, A., Bai, R.-Y., Staedtke, V., Rusk, A. W., Tung, D., Miller, M., Roix, J., et al. (2014) · Science Translational Medicine

Bacterial Cancer TherapyClostridium difficile and Clostridium perfringens research

Cited by 400

Itraconazole and Arsenic Trioxide Inhibit Hedgehog Pathway Activation and Tumor Growth Associated with Acquired Resistance to Smoothened Antagonists

Kim, J., Aftab, B. T., Tang, J. Y., Kim, D., Lee, A. H., Rezaee, M., Kim, J., Chen, B., King, E. M., Borodovsky, A., et al. (2013) · Cancer Cell

Hedgehog Signaling Pathway StudiesGlioma Diagnosis and Treatment

Cited by 346

Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome

Staedtke, V., Bai, R.-Y., Kim, K., Darvas, M., Davila, M. L., Riggins, G. J., Rothman, P. B., Papadopoulos, N., Kinzler, K. W., Vogelstein, B., et al. (2018) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 277

Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT inhibitor decitabine

Turcan, S., Fabius, A. W. M., Borodovsky, A., Pedraza, A., Brennan, C., Huse, J., Viale, A., Riggins, G. J., & Chan, T. A. (2013) · Oncotarget

Glioma Diagnosis and TreatmentAcute Myeloid Leukemia Research

Cited by 240

Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme

Bai, R.-Y., Staedtke, V., Aprhys, C. M., Gallia, G. L., & Riggins, G. J. (2011) · Neuro-Oncology

Glioma Diagnosis and TreatmentHeterocyclic Compound Synthesis and Bioactivity

Cited by 201

G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma

Wang, Y., Yang, J., Wild, A. T., Wu, W. H., Shah, R., Danussi, C., Riggins, G. J., Kannan, K., Sulman, E. P., Chan, T. A., et al. (2019) · Nature Communications

DNA and Nucleic Acid ChemistryGlioma Diagnosis and Treatment

Cited by 184

A mouse atlas of gene expression: Large-scale digital gene-expression profiles from precisely defined developing C57BL/6J mouse tissues and cells

Siddiqui, A. S., Khattra, J., Delaney, A. D., Zhao, Y., Astell, C., Asano, J., Babakaiff, R., Barber, S., Beland, J., Bohacec, S., et al. (2005) · Proceedings of the National Academy of Sciences

Genomics and Phylogenetic StudiesGene expression and cancer classification

Cited by 116

A comparison of gene expression profiles produced by SAGE, long SAGE, and oligonucleotide chips

Lu, J., Lal, A., Merriman, B., Nelson, S., & Riggins, G. (2004) · Genomics

Gene expression and cancer classificationGenomics and Phylogenetic Studies

Cited by 55

ABI3 ectopic expression reduces in vitro and in vivocell growth properties while inducing senescence

Latini, F. R., Hemerly, J. P., Freitas, B. C., Oler, G., Riggins, G. J., & Cerutti, J. M. (2011) · BMC Cancer

Cancer-related Molecular PathwaysTelomeres, Telomerase, and Senescence

Cited by 48

Feasibility of using NF1-GRD and AAV for gene replacement therapy in NF1-associated tumors

Bai, R.-Y., Esposito, D., Tam, A. J., McCormick, F., Riggins, G. J., Wade Clapp, D., & Staedtke, V. (2019) · Gene Therapy

Virus-based gene therapy researchNeurofibromatosis and Schwannoma Cases

Cited by 38

Mebendazole prevents distant organ metastases in part by decreasing ITGβ4 expression and cancer stemness

Joe, N. S., Godet, I., Milki, N., Ain, N. U. I., Oza, H. H., Riggins, G. J., & Gilkes, D. M. (2022) · Breast Cancer Research

Cancer Cells and MetastasisBreast Cancer Treatment Studies

Cited by 24

Mebendazole Treatment Disrupts the Transcriptional Activity of Hypoxia-Inducible Factors 1 and 2 in Breast Cancer Cells

Joe, N. S., Wang, Y., Oza, H. H., Godet, I., Milki, N., Riggins, G. J., & Gilkes, D. M. (2023) · Cancers

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 9