Cited by 338Mitochondrial Function and PathologyAutophagy in Disease and TherapyAdipose Tissue and Metabolism

Repairing mitochondrial dysfunction in disease

Open access
Sorrentino, Vincenzo, Menzies, Keir J., Auwerx, Johan·2018·Annual Review of Pharmacology and Toxicology

Abstract

Mitochondria are essential organelles for many aspects of cellular homeostasis, including energy harvesting through oxidative phosphorylation. Alterations of mitochondrial function not only impact on cellular metabolism but also critically influence whole-body metabolism, health, and life span. Diseases defined by mitochondrial dysfunction have expanded from rare monogenic disorders in a strict sense to now also include many common polygenic diseases, including metabolic, cardiovascular, neurodegenerative, and neuromuscular diseases. This has led to an intensive search for new therapeutic and preventive strategies aimed at invigorating mitochondrial function by exploiting key components of mitochondrial biogenesis, redox metabolism, dynamics, mitophagy, and the mitochondrial unfolded protein response. As such, new findings linking mitochondrial function to the progression or outcome of this ever-increasing list of diseases has stimulated the discovery and development of the first true mitochondrial drugs, which are now entering the clinic and are discussed in this review.

Integrity signals

Registry

Crossref · 10.1146/annurev-pharmtox-010716-104908

Cites

355 of 355 references verified0 citation errors · 0 not checkable

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1 retracted

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Authors
Sorrentino, V., Menzies, K. J., & Auwerx, J.
Affiliations
  • École Polytechnique Fédérale de Lausanne (CH)
  • University of Ottawa (CA)
Venue
Annual Review of Pharmacology and Toxicology
Published
2018-01-06
Volume
58
Issue
1
Pages
353-389
ISSN
  • 0362-1642 (ISSN-L)
  • 1545-4304
OpenAlex
W2612876306
Cited by
337
References
356
Citations by year
2026: 25 · 2025: 59 · 2024: 55 · 2023: 36 · 2022: 46 · 2021: 43 · 2020: 36 · 2019: 27 · 2018: 10
FWCI
1.87
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • The Annual Review of Pharmacology and Toxicology (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, other-oa)
  • National University of Singapore (submittedVersion)
  • Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
Funders
  • National Science Foundation
  • University of Ottawa
  • Kidney Foundation of Canada
  • École Polytechnique Fédérale de Lausanne (665667)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (140780, 151019, 31003A)
  • National Institutes of Health
  • Canadian Institutes of Health Research
  • National Institute on Aging (R01AG043930)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
mitochondrial dysfunction, mitochondrial disease, mitochondrial biogenesis, redox metabolism, mitochondrial dynamics, mitophagy, mitochondrial unfolded protein response, polygenic disease, metabolic disorders, neurodegenerative diseases, neuromuscular disorders, cardiovascular disease, oxidative phosphorylation, mitochondrial therapeutics
MeSH terms
Animals, Organelle Biogenesis, Humans, Mitochondria, Disease Progression, Mitochondrial Diseases

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