ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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ATR and ATRIP: Partners in Checkpoint Signaling

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<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

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A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome

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ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

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Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systemsPreprint

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Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress

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ATM-dependent phosphorylation of nibrin in response to radiation exposure

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Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

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Mdc1 couples DNA double‐strand break recognition by Nbs1 with its H2AX‐dependent chromatin retention

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An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

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Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

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ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses

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Mre11 Protein Complex Prevents Double-Strand Break Accumulation during Chromosomal DNA Replication

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Chk2 Activation Dependence on Nbs1 after DNA Damage

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A Proline-Rich Sequence Unique to MEK1 and MEK2 Is Required for Raf Binding and Regulates MEK Function

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Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway

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Ionizing radiation-induced Rad51 nuclear focus formation is cell cycle-regulated and defective in both ATM−/− and c-Abl−/− cells

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ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

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ATR: an essential regulator of genome integrity

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Non-homologous DNA end joining and alternative pathways to double-strand break repair

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53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

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Playing the End Game: DNA Double-Strand Break Repair Pathway Choice

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DNA Damage Sensing by the ATM and ATR Kinases

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Double-Strand Break End Resection and Repair Pathway Choice

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Human CtIP promotes DNA end resection

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RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins

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Replication stress and cancer

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Encoding and Decoding Cellular Information through Signaling Dynamics

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Ionizing Radiation-Induced DNA Damage, Response, and Repair

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p53-Deficient Cells Rely on ATM- and ATR-Mediated Checkpoint Signaling through the p38MAPK/MK2 Pathway for Survival after DNA Damage

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ATM and Artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2

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ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors

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The Journal of Experimental Medicine CORRESPONDENCE Oscar Fernandez-Capetillo:

Cuadrado, M., Martínez-Pastor, B., Murga, M., & Toledo, L. I. (2013)

P (2011) Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol Cell Biol 31: 573–583

Limbo, O., Porter-Goff, M. E., Rhind, N., & Russell, P. R. (2016)