Gendelman, Howard E.

A call for transparent reporting to optimize the predictive value of preclinical research

Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 1,196

The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells.

Heinzinger, N. K., Bukinsky, M. I., Haggerty, S. A., Ragland, A. M., Kewalramani, V, Lee, M. A., Gendelman, H. E., Ratner, L., Stevenson, M., & Emerman, M. (1994) · Proceedings of the National Academy of Sciences

HIV Research and TreatmentHIV/AIDS drug development and treatment

Cited by 854

Interferon-γ and Tumor Necrosis Factor-α Regulate Amyloid-β Plaque Deposition and β-Secretase Expression in Swedish Mutant APP Transgenic Mice

Yamamoto, M., Kiyota, T., Horiba, M., Buescher, J. L., Walsh, S. M., Gendelman, H. E., & Ikezu, T. (2007) · The American Journal of Pathology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 367

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Dash, P. K., Kaminski, R., Bella, R., Su, H., Mathews, S., Ahooyi, T. M., Chen, C., Mancuso, P., Sariyer, R., Ferrante, P., et al. (2019) · Nature Communications

HIV Research and TreatmentVirus-based gene therapy research

Cited by 295

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Ruan, Z., Pathak, D., Venkatesan Kalavai, S., Yoshii-Kitahara, A., Muraoka, S., Bhatt, N., Takamatsu-Yukawa, K., Hu, J., Wang, Y., Hersh, S., et al. (2021) · Brain

Alzheimer's disease research and treatmentsExtracellular vesicles in disease

Cited by 283

CNS expression of anti‐inflammatory cytokine interleukin‐4 attenuates Alzheimer's disease‐like pathogenesis in APP+PS1 bigenic mice

Kiyota, T., Okuyama, S., Swan, R. J., Jacobsen, M. T., Gendelman, H. E., & Ikezu, T. (2010) · The FASEB Journal

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 212

Overexpression of Monocyte Chemotactic Protein-1/CCL2 in β-Amyloid Precursor Protein Transgenic Mice Show Accelerated Diffuse β-Amyloid Deposition

Yamamoto, M., Horiba, M., Buescher, J. L., Huang, D., Gendelman, H. E., Ransohoff, R. M., & Ikezu, T. (2005) · The American Journal of Pathology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 137

Creation of a long-acting nanoformulated dolutegravir

Sillman, B., Bade, A. N., Dash, P. K., Bhargavan, B., Kocher, T., Mathews, S., Su, H., Kanmogne, G. D., Poluektova, L. Y., Gorantla, S., et al. (2018) · Nature Communications

HIV/AIDS drug development and treatmentNanoparticle-Based Drug Delivery

Cited by 125

Neurotheranostics as Personalized Medicines

Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews

Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

Cited by 124

CCL2 Accelerates Microglia-Mediated Aβ Oligomer Formation and Progression of Neurocognitive Dysfunction

Kiyota, T., Yamamoto, M., Xiong, H., Lambert, M. P., Klein, W. L., Gendelman, H. E., Ransohoff, R. M., & Ikezu, T. (2009) · PLoS ONE

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 114

Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection

Kadiu, I., & Gendelman, H. E. (2011) · Journal of Neuroimmune Pharmacology

HIV Research and TreatmentCellular transport and secretion

Cited by 100

Macrophages Offer A Paradigm Switch for CNS Delivery of Therapeutic Proteins

Klyachko, N. L., Haney, M. J., Zhao, Y., Manickam, D. S., Mahajan, V., Suresh, P., Hingtgen, S. D., Mosley, R. L., Gendelman, H. E., Kabanov, A. V., et al. (2014) · Nanomedicine

Nanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

Cited by 92

Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome

Ciborowski, P., Kadiu, I., Rozek, W., Smith, L., Bernhardt, K., Fladseth, M., Ricardo-Dukelow, M., & Gendelman, H. E. (2007) · Virology

HIV Research and TreatmentHIV-related health complications and treatments

Cited by 87

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice

Kiyota, T., Machhi, J., Lu, Y., Dyavarshetty, B., Nemati, M., Yokoyama, I., Mosley, R. L., & Gendelman, H. E. (2018) · Journal of Neuroimmunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 80

Pharmacokinetics of a Long-Acting Nanoformulated Dolutegravir Prodrug in Rhesus Macaques

McMillan, J., Szlachetka, A., Slack, L., Sillman, B., Lamberty, B., Morsey, B., Callen, S., Gautam, N., Alnouti, Y., Edagwa, B., et al. (2018) · Antimicrobial Agents and Chemotherapy

HIV/AIDS drug development and treatmentNanoparticle-Based Drug Delivery

Cited by 32