Cited by 81Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer’s disease mice

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Kiyota, Tomomi, Machhi, Jatin, Lu, Yaman, Dyavarshetty, Bhagyalaxmi, Nemati, Maryam, Yokoyama, Izumi, Mosley, R.L., Gendelman, Howard E.·2018·Journal of Neuroimmunology

Abstract

We investigated the effects of granulocyte-macrophage colony stimulating factor (GM-CSF) on behavioral and pathological outcomes in Alzheimer's disease (AD) and non-transgenic mice. GM-CSF treatment in AD mice reduced brain amyloidosis, increased plasma Aβ, and rescued cognitive impairment with increased hippocampal expression of calbindin and synaptophysin and increased levels of doublecortin-positive cells in the dentate gyrus. These data extend GM-CSF pleiotropic neuroprotection mechanisms in AD and include regulatory T cell-mediated immunomodulation of microglial function, Aβ clearance, maintenance of synaptic integrity, and induction of neurogenesis. Together these data support further development of GM-CSF as a neuroprotective agent for AD.

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Crossref · 10.1016/j.jneuroim.2018.03.009

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  • The levels of antiageing factors such as GDF11, TIMP2 and CSF2 are reduced; these factors are linked to improved microglial phagocytosis and neurogenesis and reduce the amyloid-β load, thus enhancing cognition.

    “In contrast, the levels of antiageing factors, such as GDF11, tissue inhibitor of metalloproteinase 2 (TIMP2) and granulocyte‒macrophage colony stimulating factor (CSF2), are reduced. These factors are linked to improved microglial phagocytosis and neurogenesis and reduce the Aβ load, thus enhancing cognition.72,322–324”

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Authors
Kiyota, T., Machhi, J., Lu, Y., Dyavarshetty, B., Nemati, M., Yokoyama, I., Mosley, R. L., & Gendelman, H. E.
Affiliations
University of Nebraska Medical Center (US)
Corresponding author
Gendelman, Howard E.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2018-06
Volume
319
Pages
80-92
ISSN
0165-5728 (ISSN-L)
OpenAlex
W2791554250
Cited by
80
References
120
Citations by year
2026: 3 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 12 · 2021: 11 · 2020: 12 · 2019: 4 · 2018: 1
FWCI
4.80
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroimmunology (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health (NS036126, AG043540, MH062261, NS034239, NS043985, DA028555, MH064570)
  • U.S. Department of Defense (421, 20-09A, 421\u201320-09 A)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
GM-CSF, Alzheimer's disease, neuroprotection, amyloid-beta, cerebral amyloidosis, cognitive impairment, hippocampus, synaptophysin, calbindin, doublecortin, dentate gyrus neurogenesis, microglial function, regulatory T cells, immunomodulation, synaptic integrity
MeSH terms
Alzheimer Disease, Animals, Brain, Mice, Transgenic, Granulocyte-Macrophage Colony-Stimulating Factor, Neuroprotective Agents, Mice

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