Chai, Li

Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak

Dai, M., Liu, D., Liu, M., Zhou, F., Li, G., Chen, Z., Zhang, Z., You, H., Wu, M., Zheng, Q., et al. (2020) · Cancer Discovery

COVID-19 and healthcare impactsCOVID-19 Clinical Research Studies

Cited by 1,589

Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

Zhang, J., Tam, W.-L., Tong, G. Q., Wu, Q., Chan, H.-Y., Soh, B.-S., Lou, Y., Yang, J., Ma, Y., Chai, L., et al. (2006) · Nature Cell Biology

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 568

Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma

Yong, K. J., Gao, C., Lim, J. S. J., Yan, B., Yang, H., Dimitrov, T., Kawasaki, A., Ong, C. W., Wong, K.-F., Lee, S., et al. (2013) · New England Journal of Medicine

Hepatocellular Carcinoma Treatment and PrognosisLiver physiology and pathology

Cited by 257

SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice

Ma, Y., Cui, W., Yang, J., Qu, J., Di, C., Amin, H. M., Lai, R., Ritz, J., Krause, D. S., & Chai, L. (2006) · Blood

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 215

Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex

Lu, J., Jeong, H., Kong, N., Yang, Y., Carroll, J., Luo, H. R., Silberstein, L. E., YupoMa, & Chai, L. (2009) · PLoS ONE

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 168

A Novel SALL4/OCT4 Transcriptional Feedback Network for Pluripotency of Embryonic Stem Cells

Yang, J., Gao, C., Chai, L., & Ma, Y. (2010) · PLoS ONE

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 152

SALL4 is a key regulator of survival and apoptosis in human leukemic cells

Yang, J., Chai, L., Gao, C., Fowles, T. C., Alipio, Z., Dang, H., Xu, D., Fink, L. M., Ward, D. C., & Ma, Y. (2008) · Blood

Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processes

Cited by 132

SALL4, the missing link between stem cells, development and cancer

Tatetsu, H., Kong, N. R., Chong, G., Amabile, G., Tenen, D. G., & Chai, L. (2016) · Gene

Pluripotent Stem Cells ResearchDevelopmental Biology and Gene Regulation

Cited by 130

ZNF143 mediates CTCF-bound promoter–enhancer loops required for murine hematopoietic stem and progenitor cell function

Zhou, Q., Yu, M., Tirado-Magallanes, R., Li, B., Kong, L., Guo, M., Tan, Z. H., Lee, S., Chai, L., Numata, A., et al. (2021) · Nature Communications

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 79

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide

Liu, B. H., Jobichen, C., Chia, C. S. B., Chan, T. H. M., Tang, J. P., Chung, T. X. Y., Li, J., Poulsen, A., Hung, A. W., Koh-Stenta, X., et al. (2018) · Proceedings of the National Academy of Sciences

Chromatin Remodeling and CancerChemical Synthesis and Analysis

Cited by 67

Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex

Gao, C., Dimitrov, T., Yong, K. J., Tatetsu, H., Jeong, H.-W., Luo, H. R., Bradner, J. E., Tenen, D. G., & Chai, L. (2013) · Blood

Acute Myeloid Leukemia ResearchHistone Deacetylase Inhibitors Research

Cited by 65

SALL4 is a key transcription regulator in normal human hematopoiesis

Gao, C., Kong, N. R., Li, A., Tatetu, H., Ueno, S., Yang, Y., He, J., Yang, J., Ma, Y., Kao, G. S., et al. (2013) · Transfusion

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 58

Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression

Kong, N. R., Bassal, M. A., Tan, H. K., Kurland, J. V., Yong, K. J., Young, J. J., Yang, Y., Li, F., Lee, J. D., Liu, Y., et al. (2021) · Cell Reports

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 56

Targeting SALL4 by entinostat in lung cancer

Yong, K. J., Li, A., Ou, W.-B., Hong, C. K. Y., Zhao, W., Wang, F., Tatetsu, H., Yan, B., Qi, L., Fletcher, J. A., et al. (2016) · Oncotarget

Histone Deacetylase Inhibitors ResearchLung Cancer Research Studies

Cited by 41

Targeting multiple cell death pathways extends the shelf life and preserves the function of human and mouse neutrophils for transfusion

Fan, Y., Teng, Y., Loison, F., Pang, A., Kasorn, A., Shao, X., Zhang, C., Ren, Q., Yu, H., Zheng, Y., et al. (2021) · Science Translational Medicine

Cell death mechanisms and regulationBlood transfusion and management

Cited by 36

SALL4: An Intriguing Therapeutic Target in Cancer Treatment

Moein, S., Tenen, D. G., Amabile, G., & Chai, L. (2022) · Cells

Protein Degradation and InhibitorsEpigenetics and DNA Methylation

Cited by 35

Leukemic survival factor SALL4 contributes to defective DNA damage repair

Wang, F., Gao, C., Lu, J., Tatetsu, H., Williams, D. A., Müller, L. U., Cui, W., & Chai, L. (2016) · Oncogene

DNA Repair MechanismsAcute Myeloid Leukemia Research

Cited by 17

Targeting transcription factors through an IMiD independent zinc finger domain

Liu, B. H., Liu, M., Radhakrishnan, S., Dai, M.-Y., Jaladanki, C. K., Gao, C., Tang, J. P., Kumari, K., Go, M. L., Vu, K. A. L., et al. (2025) · EMBO Molecular Medicine

Protein Degradation and InhibitorsChromatin Remodeling and Cancer

Cited by 8

Dissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome

Tatetsu, H., Watanabe, M., Liu, J., Tokunaga, K., Iwanaga, E., Komohara, Y., Thrash, E., Bassal, M. A., Matsuoka, M., Tenen, D. G., et al. (2023) · Clinical and Translational Medicine

Acute Myeloid Leukemia ResearchHematopoietic Stem Cell Transplantation

Cited by 1