SALL4, the missing link between stem cells, development and cancer

Tatetsu, Hiro; Kong, Nikki R.; Chong, Gao; Amabile, Giovanni; Tenen, Daniel G.; Chai, Li

doi:10.1016/j.gene.2016.02.019

Cited by 130Pluripotent Stem Cells ResearchDevelopmental Biology and Gene RegulationCancer Cells and Metastasis

SALL4, the missing link between stem cells, development and cancer

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Tatetsu, Hiro, Kong, Nikki R., Chong, Gao, Amabile, Giovanni, Tenen, Daniel G., Chai, Li·2016·Gene

DOI 10.1016/j.gene.2016.02.019PMC PMC4823161

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Abstract

There is a growing body of evidence supporting that cancer cells share many similarities with embryonic stem cells (ESCs). For example, aggressive cancers and ESCs share a common gene expression signature that includes hundreds of genes. Since ESC genes are not present in most adult tissues, they could be ideal candidate targets for cancer-specific diagnosis and treatment. This is an exciting cancer-targeting model. The major hurdle to test this model is to identify the key factors/pathway(s) within ESCs that are responsible for the cancer phenotype. SALL4 is one of few genes that can establish this link. The first publication of SALL4 is on its mutation in a human inherited disorder with multiple developmental defects. Since then, over 300 papers have been published on various aspects of this gene in stem cells, development, and cancers. This review aims to summarize our current knowledge of SALL4, including a SALL4-based approach to classify and target cancers. Many questions about this important gene still remain unanswered, specifically, on how this gene regulates cell fates at a molecular level. Understanding SALL4's molecular functions will allow development of specific targeted approaches in the future.

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SALL4 is re-expressed in a significant fraction of almost all human adult tumors.
“As a transcription factor, the uniqueness of SALL4 lies in the fact that it is expressed in embryonic cells, downregulated during development, absent in most adult tissues, and re-expressed in a significant fraction of almost all human adult tumors (Moein et al, 2022; Tatetsu et al, 2016).”
From Targeting transcription factors through an IMiD independent zinc finger domain (2025) · cites this paper as Tatetsu et al, 2016
Section 3, “SALL4 in cancers” (page not provided), reports aberrant SALL4 expression in various cancers and re-expression in a subgroup of hepatocellular carcinoma patients. It does not establish that a significant fraction of almost all human adult tumors re-express SALL4; the section also says expression is rare in epithelioid sarcomas. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Re-expression of SALL4 in different cancer types was mostly associated with increased tumor cell proliferation and decreased patient survival.
“Mostly, the re-expression of SALL4 was associated with increased tumor cell proliferation and decreased patient survival.”
From Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4 (2021) · cites this paper as [26]
Section 3 reports aberrant SALL4 expression across cancers and links SALL4 expression to poor survival in MDS and poor prognosis in HCC. The References list studies associating SALL4 with cancer-cell proliferation in breast and lung cancer. The copy does not establish that both associations hold for most cancer types in which SALL4 is re-expressed. (LLM, conf=0.82)
Experimental — accuracy not yet measured
SALL4 is absent in most adult tissues.
“As a transcription factor, the uniqueness of SALL4 lies in the fact that it is expressed in embryonic cells, downregulated during development, absent in most adult tissues, and re-expressed in a significant fraction of almost all human adult tumors (Moein et al, 2022; Tatetsu et al, 2016).”
From Targeting transcription factors through an IMiD independent zinc finger domain (2025) · cites this paper as Tatetsu et al, 2016
SALL4 aberrant re-expression has been reported for an increasing number of cancer types, such as germ cell tumors, hepatocellular carcinoma, gastric cancer, and leukemia.
“its aberrant re-expression has been reported for an increasing number of cancer types, such as germ cell tumors, hepatocellular carcinoma, gastric cancer, leukemia-, and others26”
From Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4 (2021) · cites this paper as [26]
Sall4 is crucial for early embryo development, and mice without Sall4 cannot survive beyond E6.5.
“Of note, Sall4 is crucial for the early development of embryos, and mice without Sall4 cannot survive beyond E6.540–42.”
From The NuRD complex cooperates with SALL4 to orchestrate reprogramming (2023) · cites this paper as [40]

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SALL4 as an Epithelial-Mesenchymal Transition and Drug Resistance Inducer through the Regulation of c-Myc in Endometrial Cancer
Liu, L., Zhang, J., Yang, X., Fang, C., Xu, H., & Xi, X. (2015) · PLOS ONE · doi:10.1371/journal.pone.0138515 · Cited by 67 · see citing works
Retracted
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
Shi, Y., Lan, F., Matson, C., Mulligan, P., Whetstine, J. R., Cole, P. A., Casero, R. A., & Shi, Y. (2004) · Cell · doi:10.1016/j.cell.2004.12.012 · Cited by 4,051 · see citing works
MEME: discovering and analyzing DNA and protein sequence motifs
Bailey, T. L., Williams, N., Misleh, C., & Li, W. W. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl198 · Cited by 2,671 · see citing works
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
Loh, Y., Wu, Q., Chew, J.-L., Vega, V. B., Zhang, W., Chen, X., Bourque, G., George, J., Leong, B., Liu, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1760 · Cited by 2,438 · see citing works
Proceedings of the 8th Workshop on Programming Languages and Operating Systems
Lu, S., California, S. '. A. S. 2. S. O. O. S. P. 2. M., Association for Computing Machinery-Digital Library, ACM Special Interest Group on Operating Systems, & SIGs, A. (2015) · doi:10.1145/2818302 · Cited by 1,629 · see citing works
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
Hou, P., Li, Y., Zhang, X., Liu, C., Guan, J., Li, H., Zhao, T., Ye, J., Yang, W., Liu, K., et al. (2013) · Science · doi:10.1126/science.1239278 · Cited by 1,402 · see citing works
An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells
Kim, J., Chu, J., Shen, X., Wang, J., & Orkin, S. H. (2008) · Cell · doi:10.1016/j.cell.2008.02.039 · Cited by 1,321 · see citing works
A protein interaction network for pluripotency of embryonic stem cells
Wang, J., Rao, S., Chu, J., Shen, X., Levasseur, D. N., Theunissen, T. W., & Orkin, S. H. (2006) · Nature · doi:10.1038/nature05284 · Cited by 1,094 · see citing works
The Wnt/β-catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML
Wang, Y., Krivtsov, A., Sinha, A., North, T., Goessling, W., Feng, Z.-H., Zon, L., & Armstrong, S. (2010) · Science · doi:10.1126/science.1186624 · Cited by 812 · see citing works
Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
Melton, C. A., Judson, R. L., & Blelloch, R. H. (2010) · Nature · doi:10.1038/nature08725 · Cited by 693 · see citing works
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1
Zhang, J., Tam, W.-L., Tong, G. Q., Wu, Q., Chan, H.-Y., Soh, B.-S., Lou, Y., Yang, J., Ma, Y., Chai, L., et al. (2006) · Nature Cell Biology · doi:10.1038/ncb1481 · Cited by 568 · see citing works
Self-citation
An Oct4-Centered Protein Interaction Network in Embryonic Stem Cells
van den Berg, D. L. C., Snoek, T., Mullin, N. P., Yates, A., Bezstarosti, K., Demmers, J., Chambers, I., & Poot, R. A. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.02.014 · Cited by 542 · see citing works
Cancer biology and NuRD: a multifaceted chromatin remodelling complex
Lai, A. Y., & Wade, P. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3091 · Cited by 541 · see citing works
Deterministic direct reprogramming of somatic cells to pluripotency
Rais, Y., Zviran, A., Geula, S., Gafni, O., Chomsky, E., Viukov, S., Mansour, A. A., Caspi, I., Krupalnik, V., Zerbib, M., et al. (2013) · Nature · doi:10.1038/nature12587 · Cited by 522 · see citing works
Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome
Kohlhase, J., Wischermann, A., Reichenbach, H., Froster, U., & Engel, W. (1998) · Nature Genetics · doi:10.1038/ng0198-81 · Cited by 481 · see citing works
The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome)
Basson, C. T., Cowley, G. S., Solomon, S. D., Weissman, B. M., Poznanski, A. K., Traill, T. A., Seidman, J. G., & Seidman, C. E. (1994) · New England Journal of Medicine · doi:10.1056/nejm199403313301302 · Cited by 388 · see citing works
The DNA sequence and comparative analysis of human chromosome 20
Deloukas, P., Matthews, L. H., Ashurst, J. L., Burton, J., Gilbert, J. G. R., Jones, M., Stavrides, G., Almeida, J. P., Babbage, A., Bagguley, C. L., et al. (2001) · Nature · doi:10.1038/414865a · Cited by 359 · see citing works
Transcription factor binding dynamics during human ES cell differentiation
Tsankov, A. M., Gu, H., Akopian, V., Ziller, M. J., Donaghey, J., Amit, I., Gnirke, A., & Meissner, A. (2015) · Nature · doi:10.1038/nature14233 · Cited by 349 · see citing works
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
Mansour, A. A., Gafni, O., Weinberger, L., Zviran, A., Ayyash, M., Rais, Y., Krupalnik, V., Zerbib, M., Amann‐Zalcenstein, D., Maza, I., et al. (2012) · Nature · doi:10.1038/nature11272 · Cited by 344 · see citing works
Okihiro syndrome is caused by SALL4 mutations
Kohlhase, J. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.23.2979 · Cited by 320 · see citing works
Duane Radial Ray Syndrome (Okihiro Syndrome) Maps to 20q13 and Results from Mutations in SALL4, a New Member of the SAL Family
Al-Baradie, R., Yamada, K., St. Hilaire, C., Chan, W.-M., Andrews, C., McIntosh, N., Nakano, M., Martonyi, E. J., Raymond, W. R., Okumura, S., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/343821 · Cited by 314 · see citing works
Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells
Wu, Q., Chen, X., Zhang, J., Loh, Y., Low, T. Y., Zhang, W., Zhang, W., Sze, S. K., Lim, B., & Ng, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600122200 · Cited by 288 · see citing works
Histone demethylation catalysed by LSD1 is a flavin‐dependent oxidative process
Forneris, F., Binda, C., Vanoni, M. A., Mattevi, A., & Battaglioli, E. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.03.015 · Cited by 284 · see citing works
A gene regulatory network in mouse embryonic stem cells
Zhou, Q., Chipperfield, H., Melton, D. A., & Wong, W. H. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701014104 · Cited by 280 · see citing works
The murine homolog ofSALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates withSall1in anorectal, heart, brain and kidney development
Sakaki-Yumoto, M., Kobayashi, C., Sato, A., Fujimura, S., Matsumoto, Y., Takasato, M., Kodama, T., Aburatani, H., Asashima, M., Yoshida, N., et al. (2006) · Development · doi:10.1242/dev.02457 · Cited by 264 · see citing works
FOG‐1 recruits the NuRD repressor complex to mediate transcriptional repression by GATA‐1
Wei, H., Nakazawa, M., Chen, Y., Kori, R., Vakoc, C. R., Rakowski, C., & Blobel, G. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600703 · Cited by 262 · see citing works
Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma
Yong, K. J., Gao, C., Lim, J. S. J., Yan, B., Yang, H., Dimitrov, T., Kawasaki, A., Ong, C. W., Wong, K.-F., Lee, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1300297 · Cited by 257 · see citing works
Self-citation
spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo.
Kühnlein, R. P., Frommer, G., Friedrich, M., González‐Gaitán, M., Weber, A. P. M., Wagner-Bernholz, J. F., Gehring, W. J., Jäckle, H., & Schuh, R. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06246.x · Cited by 249 · see citing works
Structure and function insights into the NuRD chromatin remodeling complex
Torchy, M., Hamiche, A., & Klaholz, B. P. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1880-8 · Cited by 244 · see citing works
Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages
Lim, C. Y., Tam, W.-L., Zhang, J., Ang, H. S., Jia, H., Lipovich, L., Ng, H.-H., Wei, C.-L., Sung, W. K., Robson, P., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.08.004 · Cited by 224 · see citing works
SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice
Ma, Y., Cui, W., Yang, J., Qu, J., Di, C., Amin, H. M., Lai, R., Ritz, J., Krause, D. S., & Chai, L. (2006) · Blood · doi:10.1182/blood-2006-02-001594 · Cited by 215 · see citing works
Self-citation
SALL4 Represents Fetal Gut Differentiation of Gastric Cancer, and is Diagnostically Useful in Distinguishing Hepatoid Gastric Carcinoma From Hepatocellular Carcinoma
Ushiku, T., Shinozaki‐Ushiku, A., Shibahara, J., Iwasaki, Y., Tateishi, Y., Funata, N., & Fukayama, M. (2010) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e3181d1dcdd · Cited by 211 · see citing works
SALL4 Is a Novel Sensitive and Specific Marker of Ovarian Primitive Germ Cell Tumors and Is Particularly Useful in Distinguishing Yolk Sac Tumor From Clear Cell Carcinoma
Cao, D., Guo, S., Allan, R. W., Molberg, K. H., & Peng, Y. S. (2009) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318198177d · Cited by 206 · see citing works
SALL4 Expression in Germ Cell and Non–Germ Cell Tumors
Miettinen, M., Wang, Z., McCue, P. A., Sarlomo‐Rikala, M., Ryś, J., Biernat, W., Lasota, J. P., & Lee, Y.-S. (2014) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000116 · Cited by 205 · see citing works
The NuRD architecture
Allen, H. F., Wade, P. A., & Kutateladze, T. G. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1256-2 · Cited by 205 · see citing works
Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells
Yang, J., Chai, L., Fowles, T. C., Alipio, Z., Xu, D., Fink, L. M., Ward, D. C., & Ma, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809321105 · Cited by 202 · see citing works
Self-citation
Sal-like protein 4 (SALL4), a stem cell biomarker in liver cancers
Oikawa, T., Kamiya, A., Zeniya, M., Chikada, H., Hyuck, A. D., Yamazaki, Y., Wauthier, E., Tajiri, H., Miller, L. D., Wang, X. W., et al. (2012) · Hepatology · doi:10.1002/hep.26159 · Cited by 195 · see citing works
Functional Antagonism between Sall4 and Plzf Defines Germline Progenitors
Hobbs, R. M., Fagoonee, S., Papa, A., Webster, K. A., Altruda, F., Nishinakamura, R., Chai, L., & Pandolfi, P. P. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.02.004 · Cited by 188 · see citing works
Self-citation
Murine inner cell mass-derived lineages depend on Sall4 function
Elling, U., Klasen, C., Eisenberger, T., Anlag, K., & Treier, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607884103 · Cited by 186 · see citing works
Mutations at the SALL4 locus on chromosome 20 result in a range of clinically overlapping phenotypes, including Okihiro syndrome, Holt-Oram syndrome, acro-renal-ocular syndrome, and patients previously reported to represent thalidomide embryopathy
Kohlhase, J., Schubert, L., Liebers, M., Rauch, A., Becker, K., Mohammed, S. N., Newbury-Ecob, R., & Reardon, W. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.7.473 · Cited by 185 · see citing works
Differential roles of Sall4 isoforms in embryonic stem cell pluripotency
Rao, S., Zhen, S., Roumiantsev, S., McDonald, L. T., Yuan, G.-C., & Orkin, S. H. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00419-10 · Cited by 173 · see citing works
Cooperative and antagonistic interactions between Sall4 and Tbx5 pattern the mouse limb and heart
Koshiba-Takeuchi, K., Takeuchi, J. K., Arruda, E. P., Kathiriya, I. S., Mo, R., Hui, C.-C., Srivastava, D., & Bruneau, B. G. (2006) · Nature Genetics · doi:10.1038/ng1707 · Cited by 170 · see citing works
Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
Lu, J., Jeong, H., Kong, N., Yang, Y., Carroll, J., Luo, H. R., Silberstein, L. E., YupoMa, & Chai, L. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005577 · Cited by 168 · see citing works
Self-citation
The Developmental Potential of iPSCs Is Greatly Influenced by Reprogramming Factor Selection
Buganim, Y., Markoulaki, S., van Wietmarschen, N., Hoke, H., Wu, T., Ganz, K., Akhtar-Zaidi, B., He, Y., Abraham, B. J., Porubsky, D., et al. (2014) · Cell Stem Cell · doi:10.1016/j.stem.2014.07.003 · Cited by 163 · see citing works
SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors
Cao, D., Humphrey, P. A., & Allan, R. W. (2009) · Cancer · doi:10.1002/cncr.24308 · Cited by 155 · see citing works
Roles of Sall4 in the generation of pluripotent stem cells from blastocysts and fibroblasts
Tsubooka, N., Ichisaka, T., Okita, K., Takahashi, K., Nakagawa, M., & Yamanaka, S. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01301.x · Cited by 154 · see citing works
A Novel SALL4/OCT4 Transcriptional Feedback Network for Pluripotency of Embryonic Stem Cells
Yang, J., Gao, C., Chai, L., & Ma, Y. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010766 · Cited by 152 · see citing works
Self-citation
Isolation, Characterization, and Organ-Specific Expression of Two Novel Human Zinc Finger Genes Related to theDrosophilaGenespalt
Kohlhase, J., Schuh, R., Dowe, G., Kühnlein, R. P., Jäckle, H., Schroeder, B., Schulz-Schaeffer, W., Kretzschmar, H. A., Köhler, A., Müller, U., et al. (1996) · Genomics · doi:10.1006/geno.1996.0631 · Cited by 145 · see citing works
A Conserved 12-Amino Acid Motif in Sall1 Recruits the Nucleosome Remodeling and Deacetylase Corepressor Complex
Lauberth, S. M., & Rauchman, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513461200 · Cited by 140 · see citing works
The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma
Zeng, S. S., Yamashita, T., Kondo, M., Nio, K., Hayashi, T., Hara, Y., Nomura, Y., Yoshida, M., Hayashi, T., Oishi, N., et al. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2013.08.024 · Cited by 140 · see citing works
MicroRNA-33b Inhibits Breast Cancer Metastasis by Targeting HMGA2, SALL4 and Twist1
Lin, Y., Liu, A. Y., Fan, C., Zheng, H., Li, Y., Zhang, C., Wu, S., Yu, D., Huang, Z., Liu, F., et al. (2015) · Scientific Reports · doi:10.1038/srep09995 · Cited by 140 · see citing works
Regulation and function of Spalt proteins during animal development
de Celis, J. F., & Barrio, R. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.072408jd · Cited by 137 · see citing works
CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5
Fujii, Y., Yoshihashi, K., Suzuki, H., Tsutsumi, S., Mutoh, H., Maeda, S., Yamagata, Y., Seto, Y., Aburatani, H., & Hatakeyama, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208651109 · Cited by 134 · see citing works
Bmi-1 is a target gene for SALL4 in hematopoietic and leukemic cells
Yang, J., Chai, L., Liu, F., Fink, L. M., Lin, P., Silberstein, L. E., Amin, H. M., Ward, D. C., & Ma, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704001104 · Cited by 133 · see citing works
Self-citation
SALL4 is a key regulator of survival and apoptosis in human leukemic cells
Yang, J., Chai, L., Gao, C., Fowles, T. C., Alipio, Z., Dang, H., Xu, D., Fink, L. M., Ward, D. C., & Ma, Y. (2008) · Blood · doi:10.1182/blood-2007-11-126326 · Cited by 132 · see citing works
Self-citation
SALL4, a novel marker for human gastric carcinogenesis and metastasis
Zhang, L., Xu, Z., Xu, X., Zhang, B., Wu, H., Wang, M., Zhang, X., Yang, T., Cai, J., Yan, Y., et al. (2013) · Oncogene · doi:10.1038/onc.2013.495 · Cited by 122 · see citing works
SALL4mutations in Okihiro syndrome (Duane-radial ray syndrome), acro-renal-ocular syndrome, and related disorders
Kohlhase, J., Chitayat, D. A., Kotzot, D., Ceylaner, S., Froster, U. G., Fuchs, S., Montgomery, T., & Rösler, B. (2005) · Human Mutation · doi:10.1002/humu.20215 · Cited by 116 · see citing works
SALL4 Expression in Gonocytes and Spermatogonial Clones of Postnatal Mouse Testes
Gassei, K., & Orwig, K. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053976 · Cited by 112 · see citing works
Sall4 regulates cell fate decision in fetal hepatic stem/progenitor cells
Oikawa, T., Kamiya, A., Kakinuma, S., Zeniya, M., Nishinakamura, R., Tajiri, H., & Nakauchi, H. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.11.018 · Cited by 108 · see citing works
NuRD Blocks Reprogramming of Mouse Somatic Cells into Pluripotent Stem Cells
Luo, M., Ling, T., Xie, W., Sun, H., Zhou, Y., Zhu, Q., Shen, M., Zong, L., Lyu, G., Zhao, Y., et al. (2013) · Stem Cells · doi:10.1002/stem.1374 · Cited by 104 · see citing works
Sall4 Is Essential for Stabilization, But Not for Pluripotency, of Embryonic Stem Cells by Repressing Aberrant Trophectoderm Gene Expression
Yuri, S., Fujimura, S., Nimura, K., Takeda, N., Toyooka, Y., Fujimura, Y.-I., Aburatani, H., Ura, K., Koseki, H., Niwa, H., et al. (2009) · Stem Cells · doi:10.1002/stem.14 · Cited by 103 · see citing works
SALL4: An emerging cancer biomarker and target
Zhang, X., Yuan, X., Zhu, W., Qian, H., & Xu, W. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.11.037 · Cited by 100 · see citing works
SALL4 is a new target in endometrial cancer
Li, A., Jiao, Y., Yong, K. J., Wang, F., Gao, C., Yan, B., Srivastava, S., Lim, G. S. D., Tang, P., He, Y., et al. (2013) · Oncogene · doi:10.1038/onc.2013.529 · Cited by 100 · see citing works
Self-citation
Early reprogramming regulators identified by prospective isolation and mass cytometry
Lujan, E., Zunder, E. R., Ng, Y. H., Goronzy, I. N., Nolan, G. P., & Wernig, M. (2015) · Nature · doi:10.1038/nature14274 · Cited by 100 · see citing works
Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases
Mei, K., Liu, A., Allan, R. W., Wang, P., Lane, Z., Abel, T. W., Wei, L., Cheng, H., Guo, S., Peng, Y. S., et al. (2009) · Modern Pathology · doi:10.1038/modpathol.2009.148 · Cited by 91 · see citing works
Developmental Expression of the Pluripotency Factor Sal-Like Protein 4 in the Monkey, Human and Mouse Testis: Restriction to Premeiotic Germ Cells
Eildermann, K., Aeckerle, N., Debowski, K., Godmann, M., Christiansen, H., Heistermann, M., Schweyer, S., Bergmann, M. M., Kliesch, S., Gromoll, J., et al. (2012) · Cells Tissues Organs · doi:10.1159/000335031 · Cited by 85 · see citing works
Stemness state regulators SALL4 and SOX2 are involved in progression and invasiveness of esophageal squamous cell carcinoma
Forghanifard, M. M., Khales, S. A., Javdani-Mallak, A., Rad, A., Farshchian, M., & Abbaszadegan, M. R. (2014) · Medical Oncology · doi:10.1007/s12032-014-0922-7 · Cited by 85 · see citing works
Differential expression of the novel oncogene, SALL4, in lymphoma, plasma cell myeloma, and acute lymphoblastic leukemia
Cui, W., Kong, N. R., Ma, Y., Amin, H. M., Lai, R. L., & Chai, L. (2006) · Modern Pathology · doi:10.1038/modpathol.3800694 · Cited by 83 · see citing works
Self-citation
Two miRNA Clusters Reveal Alternative Paths in Late-Stage Reprogramming
Parchem, R. J., Ye, J., Judson, R. L., Russa, M. F. L., Krishnakumar, R., Blelloch, A., Oldham, M. C., & Blelloch, R. H. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.01.021 · Cited by 82 · see citing works
Cloning and expression analysis of Sall4, the murine homologue of the gene mutated in Okihiro syndrome
Kohlhase, J., Heinrich, M., Liebers, M., Fröhlich Archangelo, L., Reardon, W., & Kispert, A. (2002) · Cytogenetic and Genome Research · doi:10.1159/000071048 · Cited by 82 · see citing works
SALL4 is essential for cancer cell proliferation and is overexpressed at early clinical stages in breast cancer
Watanabe (2011) · International Journal of Oncology · doi:10.3892/ijo.2011.929 · Cited by 82 · see citing works
Role of SALL4 in the progression and metastasis of colorectal cancer
Forghanifard, M. M., Moghbeli, M., Raeisossadati, R., Tavassoli, A., Mallak, A. J., Boroumand-Noughabi, S., & Abbaszadegan, M. R. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-6 · Cited by 82 · see citing works
Overexpression of SALL4 in lung cancer and its importance in cell proliferation
Watanabe, N. (2011) · Oncology Reports · doi:10.3892/or.2011.1374 · Cited by 78 · see citing works
SALL4 is directly activated by TCF/LEF in the canonical Wnt signaling pathway
Böhm, J., Sustmann, C., Wilhelm, C., & Kohlhase, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.07.124 · Cited by 77 · see citing works
High-grade Lung Adenocarcinoma With Fetal Lung–like Morphology
Morita, S., Yoshida, A., Goto, A., Ota, S., Tsuta, K., Yokozawa, K., Asamura, H., Nakajima, J., Takai, D., Mori, M., et al. (2013) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e31827e1e83 · Cited by 75 · see citing works
A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation data
MacIsaac, K. D., Gordon, D. B., Nekludova, L., Odom, D. T., Schreiber, J., Gifford, D. K., Young, R. A., & Fraenkel, E. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti815 · Cited by 74 · see citing works
Dissecting the role of aberrant DNA methylation in human leukaemia
Amabile, G., Ruscio, A. D., Müller, F., Welner, R. S., Yang, H. H., Ebralidze, A. K., Zhang, H., Levantini, E., Qi, L., Martinelli, G., et al. (2015) · Nature Communications · doi:10.1038/ncomms8091 · Cited by 72 · see citing works
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RNA-binding protein LIN28 is a marker for testicular germ cell tumors
Cao, D., Allan, R. W., Liang Cheng, C., Peng, Y. S., Guo, C. C., Dahiya, N., Akhi, S., & Li, J. (2011) · Human Pathology · doi:10.1016/j.humpath.2010.09.007 · Cited by 72 · see citing works
SALL4 as a new biomarker for early colorectal cancers
Khales, S. A., Abbaszadegan, M. R., Abdollahi, A., Raeisossadati, R., Tousi, M. F., & Forghanifard, M. M. (2014) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-014-1808-y · Cited by 72 · see citing works
Stem Cell Gene SALL4 Suppresses Transcription through Recruitment of DNA Methyltransferases
Yang, J., Corsello, T. R., & Ma, Y. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.308734 · Cited by 71 · see citing works
Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements
Akiyama, R., Kawakami, H., Wong, J., Oishi, I., Nishinakamura, R., & Kawakami, Y. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421949112 · Cited by 70 · see citing works
High-Efficiency Stem Cell Fusion-Mediated Assay Reveals Sall4 as an Enhancer of Reprogramming
Wong, C. C., Gaspar‐Maia, A., Ramalho‐Santos, M., & Pera, R. A. R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001955 · Cited by 70 · see citing works
A Sall4 mutant mouse model useful for studying the role of Sall4 in early embryonic development and organogenesis
Warren, M., Wang, W., Spiden, S., Chen‐Murchie, D., Tannahill, D., Steel, K. P., & Bradley, A. (2007) · genesis · doi:10.1002/dvg.20264 · Cited by 69 · see citing works
Sall1, a causative gene for Townes?Brocks syndrome, enhances the canonical Wnt signaling by localizing to heterochromatin
Sato, A., Kishida, S., Tanaka, T., Kikuchi, A., Kodama, T., Asashima, M., & Nishinakamura, R. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.156 · Cited by 67 · see citing works
Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex
Gao, C., Dimitrov, T., Yong, K. J., Tatetsu, H., Jeong, H.-W., Luo, H. R., Bradner, J. E., Tenen, D. G., & Chai, L. (2013) · Blood · doi:10.1182/blood-2012-04-424275 · Cited by 65 · see citing works
Self-citation
SALL4, a Stem Cell Factor, Affects the Side Population by Regulation of the ATP-Binding Cassette Drug Transport Genes
Jeong, H., Cui, W., Yang, Y., Lu, J., He, J., Li, A., Song, D. Y., Guo, Y., Liu, B. H., & Chai, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018372 · Cited by 65 · see citing works
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Malignant Rhabdoid Tumors Express Stem Cell Factors, Which Relate To the Expression of EZH2 and Id Proteins
Venneti, S., Le, P., Martínez, D., Xie, S. X., Sullivan, L. M., Rorke-Adams, L. B., Pawel, B., & Judkins, A. R. (2011) · The American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318224d2cd · Cited by 64 · see citing works
The Conserved Glutamine-rich Region of Chick Csal1 and Csal3 Mediates Protein Interactions with Other Spalt Family Members
Sweetman, D., Smith, T., Farrell, E. R., Chantry, A., & Münsterberg, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209066200 · Cited by 63 · see citing works
α-Fetoprotein–producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression
Ikeda, H., Sato, Y., Yoneda, N., Harada, K., Sasaki, M., Kitamura, S., Sudo, Y., Ooi, A., & Nakanuma, Y. (2012) · Human Pathology · doi:10.1016/j.humpath.2011.11.022 · Cited by 63 · see citing works
Circulating Tumor Cells in Patients with Testicular Germ Cell Tumors
Nastały, P., Ruf, C. G., Becker, P., Bednarz‐Knoll, N., Stoupiec, M., Kavsur, R., Hendrik Isbarn, A., Matthies, C., Wagner, W. P., Höppner, D., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2819 · Cited by 60 · see citing works
SALL4 is a key transcription regulator in normal human hematopoiesis
Gao, C., Kong, N. R., Li, A., Tatetu, H., Ueno, S., Yang, Y., He, J., Yang, J., Ma, Y., Kao, G. S., et al. (2013) · Transfusion · doi:10.1111/j.1537-2995.2012.03888.x · Cited by 58 · see citing works
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ERG and SALL4 expressions in SMARCB1/INI1-deficient tumors: a useful tool for distinguishing epithelioid sarcoma from malignant rhabdoid tumor
Kohashi, K., Yamada, Y., Hotokebuchi, Y., Yamamoto, H., Taguchi, T., Iwamoto, Y., & Oda, Y. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.10.010 · Cited by 58 · see citing works
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation
Wilson, C. H., Crombie, C., van der Weyden, L., Poulogiannis, G., Rust, A. G., Pardo, M., Gracia, T., Yu, L., Choudhary, J. S., Poulin, G. B., et al. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.91 · Cited by 57 · see citing works
RNA-binding protein LIN28 is a marker for primary extragonadal germ cell tumors: an immunohistochemical study of 131 cases
Cao, D., Liu, A., Wang, F., Allan, R. W., Mei, K., Peng, Y. S., Du, J., Guo, S., Abel, T. W., Lane, Z., et al. (2010) · Modern Pathology · doi:10.1038/modpathol.2010.195 · Cited by 57 · see citing works
Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance
Ozmadenci, D., Féraud, O., Markossian, S., Kress, E., Ducarouge, B., Gibert, B., Ge, J., Durand, I., Gadot, N., Plateroti, M., et al. (2015) · Nature Communications · doi:10.1038/ncomms8398 · Cited by 57 · see citing works
Defining Hypo-Methylated Regions of Stem Cell-Specific Promoters in Human iPS Cells Derived from Extra-Embryonic Amnions and Lung Fibroblasts
Nishino, K., Toyoda, M., Yamazaki‐Inoue, M., Makino, H., Fukawatase, Y., Chikazawa, E., Takahashi, Y., Miyagawa, Y., Okita, H., Kiyokawa, N., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013017 · Cited by 55 · see citing works
Combination of hepatocellular markers is useful for prognostication in gastric hepatoid adenocarcinoma
Osada, M., Aishima, S., Hirahashi, M., Takizawa, N., Takahashi, S., Nakamura, K., Tanaka, M., Maehara, Y., Takayanagi, R., & Oda, Y. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.02.003 · Cited by 55 · see citing works
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells
Xiong, J., Todorova, D., Su, N., Kim, J., Lee, P.-J., Shen, Z., Briggs, S. P., & Xu, Y. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201408106 · Cited by 55 · see citing works
Molecular characterization of spalt, a homeotic gene required for head and tail development in the Drosophila embryo
Frei, E., Schuh, R., Baumgartner, S., Burri, M., Noll, M., Jürgens, G., Seifert, E., Nauber, U., & Jäckle, H. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02800.x · Cited by 54 · see citing works
Immunohistochemical Expression of Embryonic Stem Cell Markers in Malignant Rhabdoid Tumors
Deisch, J. K., Raisanen, J. M., & Rakheja, D. (2011) · Pediatric and Developmental Pathology · doi:10.2350/10-09-0902-oa.1 · Cited by 54 · see citing works
Putative circulating markers of the early and advanced stages of breast cancer identified by high-resolution label-free proteomics
Panis, C., Pizzatti, L., Herrera, A. C. D. S. D. A., Cecchini, R., & Abdelhay, E. S. F. W. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.11.020 · Cited by 51 · see citing works
A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis.
Li, A.-L., Yang, Y., Gao, C., Lu, J., Jeong, H.-W., Liu, B.-H., Tang, P., Yao, X.-P., Neuberg, D., Huang, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62891 · Cited by 48 · see citing works
Self-citation
IVIC syndrome Is caused by a c.2607delA mutation in the SALL4 locus
Paradisi, I., & Arias, S. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31603 · Cited by 46 · see citing works
Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4
Bard, J. D., Gélébart, P., Amin, H. M., Young, L. C., Ma, Y., & Lai, R. L. (2009) · The FASEB Journal · doi:10.1096/fj.08-117721 · Cited by 45 · see citing works
The expression of SALL4 in patients with gliomas: high level of SALL4 expression is correlated with poor outcome
Zhang, L., Yan, Y., Jiang, Y., Cui, Y., Zou, Y., Qian, J., Luo, C., Lu, Y., & Wu, X. (2014) · Journal of Neuro-Oncology · doi:10.1007/s11060-014-1646-4 · Cited by 45 · see citing works
Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma
Hopkins, L., Rowe, I. A. C., & Houlihan, D. D. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1308785 · Cited by 45 · see citing works
SALL4 is a useful marker in the diagnostic work-up of germ cell tumors in extra-testicular locations
Camparo, P., & Compérat, É. (2012) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-012-1353-5 · Cited by 44 · see citing works
Stemness-related Factor Sall4 Interacts with Transcription Factors Oct-3/4 and Sox2 and Occupies Oct-Sox Elements in Mouse Embryonic Stem Cells
Tanimura, N., Saito, M., Ebisuya, M., Nishida, E., & Ishikawa, F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.411173 · Cited by 43 · see citing works
Serum SALL4 Is a Novel Prognosis Biomarker with Tumor Recurrence and Poor Survival of Patients in Hepatocellular Carcinoma
Han, S., Wang, J.-L., Guo, X.-J., He, C., Ying, X., Ma, J., Zhang, Y., Zhao, Q. C., & Zhu, Q. (2014) · Journal of Immunology Research · doi:10.1155/2014/262385 · Cited by 42 · see citing works
Sal‐like 4 (SALL4) suppresses CDH1 expression and maintains cell dispersion in basal‐like breast cancer
Itou, J., Matsumoto, Y., Yoshikawa, K., & Toi, M. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.07.049 · Cited by 40 · see citing works
A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial midline defects and mild features of Okihiro syndrome
Miertus, J., Borozdin, W., Frecer, V., Tonini, G., Bertok, S., Amoroso, A., Miertus, S., & Kohlhase, J. (2006) · Human Genetics · doi:10.1007/s00439-005-0124-7 · Cited by 39 · see citing works
Dissecting the role of SALL4, a newly identified stem cell factor, in chronic myelogenous leukemia
Lu, J., Ma, Y., Kong, N., Alipio, Z., Gao, C., Krause, D. S., Silberstein, L. E., & Chai, L. (2011) · Leukemia · doi:10.1038/leu.2011.65 · Cited by 39 · see citing works
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Histone Lysine-specific Demethylase 1 (LSD1) Protein Is Involved in Sal-like Protein 4 (SALL4)-mediated Transcriptional Repression in Hematopoietic Stem Cells
Liu, L., Souto, J., Liao, W., Jiang, Y., Li, Y., Nishinakamura, R., Huang, S., Rosengart, T. K., Yang, V. W., Schuster, M. K., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.506568 · Cited by 36 · see citing works
Investigating the role of FGF‐2 in stem cell maintenance by global phosphoproteomics profiling
Zoumaro-Djayoon, A. D., Ding, V., Foong, L. Y., Choo, A. B. H., Heck, A. J. R., & Muñoz, J. (2011) · PROTEOMICS · doi:10.1002/pmic.201100048 · Cited by 35 · see citing works
Undifferentiated carcinoma of the esophagus: a clinicopathological study of 16 cases
Singhi, A. D., Seethala, R. R., Nason, K. S., Foxwell, T. J., Roche, R. L., McGrath, K. M., Levy, R. M., Luketich, J. D., & Davison, J. M. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.11.021 · Cited by 35 · see citing works
A Cdx4-Sall4 Regulatory Module Controls the Transition from Mesoderm Formation to Embryonic Hematopoiesis
Paik, E. J., Mahony, S., White, R. M., Price, E., DiBiase, A., Dorjsuren, B., Mosimann, C., Davidson, A. J., Gifford, D. K., & Zon, L. I. (2013) · Stem Cell Reports · doi:10.1016/j.stemcr.2013.10.001 · Cited by 35 · see citing works
Mutations in SALL4 in malformed Father and Daughter postulated previously due to reflect mutagenesis by thalidomide
Kohlhase, J., & Holmes, L. B. (2004) · Birth Defects Research Part A Clinical and Molecular Teratology · doi:10.1002/bdra.20050 · Cited by 34 · see citing works
Primary mediastinal seminomas: a comprehensive immunohistochemical study with a focus on novel markers
Weissferdt, A., Rodriguez‐Canales, J., Liu, H., Fujimoto, J., Wistuba, I. I., & Moran, C. A. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.11.009 · Cited by 34 · see citing works
SALL4 Expression in Hepatocellular Carcinomas Is Associated with EpCAM-Positivity and a Poor Prognosis
Park, H., Lee, H., Seo, A. N., Cho, J. Y., Choi, Y., Yoon, Y., Han, H., Park, Y. N., & Kim, H. (2015) · Journal of Pathology and Translational Medicine · doi:10.4132/jptm.2015.07.09 · Cited by 33 · see citing works
Sumoylation Is Important for Stability, Subcellular Localization, and Transcriptional Activity of SALL4, an Essential Stem Cell Transcription Factor
Yang, F., Yao, Y., Jiang, Y., Lu, L., Ma, Y., & Dai, W. H. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.391441 · Cited by 33 · see citing works
Aberrant expression of SALL4 in acute B cell lymphoblastic leukemia: Mechanism, function, and implication for a potential novel therapeutic target
Ueno, S., Lu, J., He, J., Li, A., Zhang, X., Ritz, J., Silberstein, L. E., & Chai, L. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.01.005 · Cited by 33 · see citing works
Self-citation
A cohesin–OCT4 complex mediates Sox enhancers to prime an early embryonic lineage
Abboud, N., Moore‐Morris, T., Hiriart, E., Yang, H. H., Bezerra, H. L. D. O., Gualazzi, M.-G., Stefanovic, S., Guénantin, A.-C., Evans, S. Μ., & Pucéat, M. (2015) · Nature Communications · doi:10.1038/ncomms7749 · Cited by 33 · see citing works
High cytoplasmic expression of SALL4 predicts a malignant phenotype and poor prognosis of breast invasive ductal carcinoma
YUE, X., Xiao, L., Yang, Y., Liu, W., ZHANG, K., Shi, G.-Y., Zhou, H., Geng, J., NING, X., Wu, J., et al. (2015) · Neoplasma · doi:10.4149/neo_2015_119 · Cited by 33 · see citing works
Molecular analysis of gastric differentiated‐type intramucosal and submucosal cancers
Sugai, T., Habano, W., Endoh, M., Konishi, Y., Akasaka, R., Toyota, M., Yamano, H., Koeda, K., Wakabayashi, G., & Suzuki, K. (2010) · International Journal of Cancer · doi:10.1002/ijc.25271 · Cited by 32 · see citing works
Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes
Wang, F., Guo, Y., Chen, Q., Yang, Z., Ning, N., Zhang, Y., Xu, Y.-G., Xu, X., Tong, C., Chai, L., et al. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-73 · Cited by 31 · see citing works
Self-citation
Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus
Young, J. J., Kjolby, R. A. S., Kong, N. R., Monica, S. D., & Harland, R. M. (2014) · Development · doi:10.1242/dev.099374 · Cited by 31 · see citing works
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Differential SALL 4 immunoexpression in malignant rhabdoid tumours and epithelioid sarcomas
Yoshida, A., Asano, N., Kawai, A., Kawamoto, H., Nakazawa, A., Kishimoto, H., & Kushima, R. (2014) · Histopathology · doi:10.1111/his.12460 · Cited by 29 · see citing works
Overexpression of the novel oncogene SALL4 and activation of the Wnt/β-catenin pathway in myelodysplastic syndromes
Shuai, X., Zhou, D., Shen, T., Wu, Y., Zhang, J., Wang, X., & Li, Q. (2009) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2009.06.006 · Cited by 28 · see citing works
SALL4 is a novel therapeutic target in intrahepatic cholangiocarcinoma
Deng, G., Zhu, L., Huang, F., Nie, W., Huang, W., Xu, H., Zheng, S., Yi, Z., & Wan, T. (2015) · Oncotarget · doi:10.18632/oncotarget.4862 · Cited by 26 · see citing works
Aberrant hypomethylation of SALL4 gene in patients with myelodysplastic syndrome
Lin, J., Qian, J., Yao, D., Qian, W., Yang, J. C., Wang, C., Chai, H., Ma, J., Deng, Z., Li, Y., et al. (2012) · Leukemia Research · doi:10.1016/j.leukres.2012.10.014 · Cited by 23 · see citing works
SALL 4 immunohistochemistry in non‐small‐cell lung carcinomas
Fujimoto, M., Sumiyoshi, S., Yoshizawa, A., Sonobe, M., Kobayashi, M., Moriyoshi, K., Kido, A., Tanaka, C., Koyanagi, I., Date, H., et al. (2013) · Histopathology · doi:10.1111/his.12241 · Cited by 23 · see citing works
Mutational analysis of SAL-Like 4 (SALL4) in Han Chinese women with premature ovarian failure
Wang, B., Li, L., Ni, F., Song, J., Wang, J., Mu, Y., Ma, X., & Cao, Y. (2009) · Molecular Human Reproduction · doi:10.1093/molehr/gap046 · Cited by 23 · see citing works
Synergistic cooperation of Sall4 and Cyclin D1 in transcriptional repression
Böhm, J., Kaiser, F. J., Borozdin, W., Depping, R., & Kohlhase, J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.050 · Cited by 23 · see citing works
Overexpression of Karyopherin 2 in Human Ovarian Malignant Germ Cell Tumor Correlates with Poor Prognosis
He, L., Ding, H., Wang, J.-H., Zhou, Y., Li, L., Yu, Y.-H., Huang, L., Jia, W.-H., Zeng, M., Yun, J., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042992 · Cited by 23 · see citing works
The differential expression pattern of the BMI-1, SALL4 and ABCA3 genes in myeloid leukemia
Shen, Q., Liu, S., Hu, J., Chen, S., Yang, L., Li, B., Wu, X., Ma, Y., Yang, J., Ma, Y., et al. (2012) · Cancer Cell International · doi:10.1186/1475-2867-12-42 · Cited by 22 · see citing works
Novel approach for detecting global epigenetic alterations associated with tumor cell aneuploidy
Habano, W., Sugai, T., Jiao, Y., & Nakamura, S. (2007) · International Journal of Cancer · doi:10.1002/ijc.22847 · Cited by 21 · see citing works
Clinicopathologic characteristics of SALL4-immunopositive hepatocellular carcinoma
Shibahara, J., Ando, S., Hayashi, A., Sakamoto, Y., Hesegawa, K., Kokudo, N., & Fukayama, M. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-721 · Cited by 20 · see citing works
Correction: Stem Cell Factor SALL4 Represses the Transcriptions of PTEN and SALL1 through an Epigenetic Repressor Complex
Lu, J., Jeong, H., Kong, N. R., Yang, Y., Carroll, J., Luo, H. R., Silberstein, L. E., YupoMa, & Chai, L. (2009) · PLoS ONE · doi:10.1371/annotation/e0bd3a57-1ce4-4eaf-83de-034d39cac787 · Cited by 20 · see citing works
Self-citation
Aberrant hypomethylation of SALL4 gene is associated with intermediate and poor karyotypes in acute myeloid leukemia
Ma, J., Qian, J., Lin, J., Qian, W., Yang, J. C., Wang, C., Chai, H., Li, Y., Chen, Q., & Qian, Z. Y. (2012) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2012.11.018 · Cited by 19 · see citing works
Spalt‐like transcription factor 4 immunopositivity is associated with epithelial cell adhesion molecule expression in combined hepatocellular carcinoma and cholangiocarcinoma
Tanaka, Y., Aishima, S., Kohashi, K., Okumura, Y., Wang, H., Hida, T., Kotoh, K., Shirabe, K., Maehara, Y., Takayanagi, R., et al. (2015) · Histopathology · doi:10.1111/his.12806 · Cited by 17 · see citing works
Identification of the nuclear localization signal of SALL4B, a stem cell transcription factor
Wu, M., Yang, F., Ren, Z., Jiang, Y., Ma, Y., Chen, C., & Dai, W. H. (2014) · Cell Cycle · doi:10.4161/cc.28418 · Cited by 13 · see citing works
The expression and oncogenic effects of the embryonic stem cell marker SALL4 in ALK-positive anaplastic large cell lymphoma
Wang, P., Zhang, J. D., Wu, F., Ye, X., Sharon, D. M., Hitt, M., McMullen, T. P. W., Hegazy, S. A., Gélébart, P., Yang, J., et al. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.06.005 · Cited by 12 · see citing works
An atypical 0.73 MB microduplication of 22q11.21 and a novel SALL4 missense mutation associated with thumb agenesis and radioulnar synostosis
Diehl, A., Mu, W., Batista, D., & Gunay‐Aygun, M. (2015) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.37066 · Cited by 12 · see citing works
Synergistic Transcriptional and Post-Transcriptional Regulation of ESC Characteristics by Core Pluripotency Transcription Factors in Protein-Protein Interaction Networks
Li, L., Zhang, L., Liu, G., Feng, R., Jiang, Y., Yang, L., Zhang, S., Liao, M., & Hua, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105180 · Cited by 7 · see citing works
Mediastinal seminoma: A case report with special emphasis on SALL4 as a new immunocytochemical marker
Iwamoto, N., Ishida, M., Yoshida, K., Kagotani, A., Iwai, M., & Okabe, H. (2012) · Diagnostic Cytopathology · doi:10.1002/dc.22826 · Cited by 6 · see citing works

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Chu, X., Tian, W., Ning, J., Xiao, G., Zhou, Y., Wang, Z., Zhai, Z., Tanzhu, G., Yang, J., & Zhou, R. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01851-y · Cited by 597 · see citing works
Oral Estrogen Receptor PROTAC Vepdegestrant (ARV-471) Is Highly Efficacious as Monotherapy and in Combination with CDK4/6 or PI3K/mTOR Pathway Inhibitors in Preclinical ER+ Breast Cancer Models
Gough, S. M., Flanagan, J. J., Teh, J. L. F., Andreoli, M., Rousseau, E., Pannone, M., Bookbinder, M., Willard, R. R., Davenport, K., Bortolon, E., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-3465 · Cited by 212 · see citing works
The nucleosome remodeling and deacetylase complex in development and disease
Basta, J., & Rauchman, M. (2015) · Translational Research · doi:10.1016/j.trsl.2014.05.003 · Cited by 191 · see citing works
Epithelial‐mesenchymal Transition and Cancer Stem Cells: At the Crossroads of Differentiation and Dedifferentiation
Wang, H., & Unternaehrer, J. (2018) · Developmental Dynamics · doi:10.1002/dvdy.24678 · Cited by 121 · see citing works
Hepatoid adenocarcinoma of the stomach: a unique subgroup with distinct clinicopathological and molecular features
Wang, Y., Sun, L. N., Li, Z., Gao, J., Ge, S., Zhang, C., Yuan, J., Wang, X., Li, J., Lü, Z., et al. (2019) · Gastric Cancer · doi:10.1007/s10120-019-00965-5 · Cited by 97 · see citing works
New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation
Tan, J. L., Li, F., Yeo, J. Z. Z., Yong, K. J., Bassal, M. A., Ng, G. H., Lee, M. Y., Leong, C. Y., Tan, H. K., Wu, C.-S., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.08.022 · Cited by 64 · see citing works
Self-citation
Demethylation and Up-Regulation of an Oncogene after Hypomethylating Therapy
Liu, Y., Kwon, J., Fabiani, E., Xiao, Z., Liu, Y. V., Follo, M. Y., Liu, J., Huang, H., Gao, C., Liu, J., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2119771 · Cited by 58 · see citing works
Self-citation
Zinc finger protein SALL4 functions through an AT-rich motif to regulate gene expression
Kong, N. R., Bassal, M. A., Tan, H. K., Kurland, J. V., Yong, K. J., Young, J. J., Yang, Y., Li, F., Lee, J. D., Liu, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108574 · Cited by 56 · see citing works
Self-citation
HER2 is frequently overexpressed in hepatoid adenocarcinoma and gastric carcinoma with enteroblastic differentiation: a comparison of 35 cases to 334 gastric carcinomas of other histological types
Fujimoto, M., Matsuzaki, I., Nishino, M., Iwahashi, Y., Warigaya, K., Kojima, F., Ōno, K., & Murata, S. (2018) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2017-204928 · Cited by 53 · see citing works
Oncofetal proteins and cancer stem cells
Yan, Q., Fang, X., Li, C., Lan, P., & Guan, X. (2022) · Essays in Biochemistry · doi:10.1042/ebc20220025 · Cited by 51 · see citing works
SALL4 promotes gastric cancer progression through activating CD44 expression
Yuan, X., Zhang, X., Zhang, W., Liang, W., Zhang, P., Shi, H., Zhang, B., Shao, M., Yan, Y., Qian, H., et al. (2016) · Oncogenesis · doi:10.1038/oncsis.2016.69 · Cited by 45 · see citing works
The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis
Yang, L., Liu, L., Gao, H., Pinnamaneni, J., Sanagasetti, D., Singh, V., Wang, K., Mathison, M., Zhang, Q.-Z., Chen, F.-J., et al. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0531-y · Cited by 39 · see citing works
The NuRD complex cooperates with SALL4 to orchestrate reprogramming
Wang, B., Li, C., Ming, J., Wu, L., Fang, S., Huang, Y., Lin, L., Liu, H., Kuang, J., Zhao, C., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38543-0 · Cited by 39 · see citing works
“5 40 – 42 .”
Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
Pagliaroli, L., Porazzi, P., Curtis, A. T., Scopa, C., Mikkers, H. M. M., Freund, C., Daxinger, L., Deliard, S., Welsh, S. A., Offley, S. R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26810-x · Cited by 41 · see citing works
Oncofetal gene SALL4 and prognosis in cancer: A systematic review with meta-analysis
Nicolè, L., Sanavia, T., Veronese, N., Cappellesso, R., Luchini, C., Dabrilli, P., & Fassina, A. (2017) · Oncotarget · doi:10.18632/oncotarget.14952 · Cited by 39 · see citing works
SALL4 as a transcriptional and epigenetic regulator in normal and leukemic hematopoiesis
Yang, J. (2018) · Biomarker Research · doi:10.1186/s40364-017-0115-6 · Cited by 39 · see citing works
SALL Proteins; Common and Antagonistic Roles in Cancer
Álvarez, C., Quiroz, A., Benítez-Riquelme, D., Riffo, E., Castro, A. F., & Pincheira, R. (2021) · Cancers · doi:10.3390/cancers13246292 · Cited by 37 · see citing works
The Impact of Iron Chelators on the Biology of Cancer Stem Cells
Szymonik, J., Wala, K., Górnicki, T., Saczko, J., Pencakowski, B., & Kulbacka, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010089 · Cited by 36 · see citing works
SALL4: An Intriguing Therapeutic Target in Cancer Treatment
Moein, S., Tenen, D. G., Amabile, G., & Chai, L. (2022) · Cells · doi:10.3390/cells11162601 · Cited by 35 · see citing works
Self-citation
Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4
Diener, J., Baggiolini, A., Pernebrink, M., Dalcher, D., Lerra, L., Cheng, P. F., Varum, S., Häusel, J., Stierli, S., Treier, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25326-8 · Cited by 34 · see citing works
Cancer stem cells: Signaling pathways and therapeutic targeting
Talukdar, J., Srivastava, T. P., Sahoo, O. S., Karmakar, A., Rai, A. K., Sarma, A., Gogoi, G., Alqahtani, M. S., Abbas, M. A. E., Dhar, R., et al. (2023) · MedComm – Oncology · doi:10.1002/mog2.62 · Cited by 33 · see citing works
miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer
Jiang, X., & Wang, Z. (2018) · Oncology Letters · doi:10.3892/ol.2018.8997 · Cited by 28 · see citing works
Integrated clinicopathological and immunohistochemical analysis of gastric adenocarcinoma with hepatoid differentiation: an exploration of histogenesis, molecular characteristics, and prognostic markers
He, F., Fu, Y. S., Sun, Q., Geng, P., Zheng, Z., Pu, X., Shi, J., & Fan, X. (2021) · Human Pathology · doi:10.1016/j.humpath.2021.02.003 · Cited by 26 · see citing works
SOX1 is correlated to stemness state regulator SALL4 through progression and invasiveness of esophageal squamous cell carcinoma
Rad, A., Dizghandi, S. E., Abbaszadegan, M. R., Taghechian, N., Najafi, M., & Forghanifard, M. M. (2016) · Gene · doi:10.1016/j.gene.2016.08.045 · Cited by 25 · see citing works
Up-Regulation of SALL4 Is Associated With Survival and Progression via Putative WNT Pathway in Gastric Cancer
Yang, Y., Wang, X., Liu, Y., Hu, Y., Li, Z., Li, Z., Bu, Z., Wu, X., Zhang, L., & Ji, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.600344 · Cited by 25 · see citing works
Sal-like 4 protein levels in breast cancer cells are post-translationally down-regulated by tripartite motif–containing 21
Itou, J., Li, W., Ito, S., Tanaka, S., Matsumoto, Y., Sato, F., & Toi, M. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000245 · Cited by 25 · see citing works
VHL mutation-mediated SALL4 overexpression promotes tumorigenesis and vascularization of clear cell renal cell carcinoma via Akt/GSK-3β signaling
Sun, J., Tang, Q., Gao, Y., Zhang, W., Zhao, Z., Yang, F., Hu, X., Zhang, D., Wang, Y., Zhang, H., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01609-8 · Cited by 23 · see citing works
Deciphering the whale's secrets to have a long life
Lagunas‐Rangel, F. A. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111425 · Cited by 23 · see citing works
miR-497-5p/SALL4 axis promotes stemness phenotype of choriocarcinoma and forms a feedback loop with DNMT-mediated epigenetic regulation
Peng, Z., Zhang, Y., Shi, D., Jia, Y., Shi, H., & Liu, H. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04315-1 · Cited by 22 · see citing works
SALL4 suppresses reactive oxygen species in pancreatic ductal adenocarcinoma phenotype via FoxM1/Prx III axis
Huynh, D. L., Zhang, J., Chandimali, N., Ghosh, M., Gera, M., Kim, N., Park, Y. H., Kwon, T., & Jeong, D. K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.145 · Cited by 21 · see citing works
Targeted delivery of nanomedicines to glioblastoma: Overcoming the clinical barrier
Nayak, A., Warrier, N. M., Raman, R., Prabhu, V., & Kumar, P. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105980 · Cited by 20 · see citing works
The Sal-like 4 - integrin α6β1 network promotes cell migration for metastasis via activation of focal adhesion dynamics in basal-like breast cancer cells
Itou, J., Tanaka, S., Li, W., Iida, A., Sehara‐Fujisawa, A., Sato, F., & Toi, M. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.10.012 · Cited by 20 · see citing works
Ubiquitin-Specific Protease 3 Deubiquitinates and Stabilizes Oct4 Protein in Human Embryonic Stem Cells
Rhie, B., Antao, A. M., Karapurkar, J. K., Kim, M.-S., Jo, W.-J., Ramakrishna, S., & Kim, K.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115584 · Cited by 20 · see citing works
Subsets of cancer cells expressing CX3CR1 are endowed with metastasis-initiating properties and resistance to chemotherapy
DiNatale, A., Kaur, R., Chen, Q., Zhang, J., Marchioli, M., Ipe, D., Castelli, S., McNair, C. M., Kumar, G., Meucci, O., et al. (2022) · Oncogene · doi:10.1038/s41388-021-02174-w · Cited by 19 · see citing works
Clinically conserved genomic subtypes of gastric adenocarcinoma
Jeong, Y. S., Eun, Y., Lee, S. H., Kang, S.-H., Yim, S. Y., Kim, E. H., Noh, J. K., Sohn, B. H., Woo, S. R., Kong, M., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01796-w · Cited by 19 · see citing works
The role of ESCO2, SALL4 and TBX5 genes in the susceptibility to thalidomide teratogenesis
Gomes, J. D. A., Kowalski, T. W., Fraga, L. R., Macedo, G. S., Sanseverino, M. T. V., Schüler‐Faccini, L., & Vianna, F. S. L. (2019) · Scientific Reports · doi:10.1038/s41598-019-47739-8 · Cited by 19 · see citing works
Detention and Identification of Cancer Stem Cells in Esophageal Squamous Cell Carcinoma
Islam, F., Gopalan, V., & Lam, A. K.-Y. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0377-2_14 · Cited by 19 · see citing works
MEIS1 promotes expression of stem cell markers in esophageal squamous cell carcinoma
Zargari, S., Khameneh, S. N., Rad, A., & Forghanifard, M. M. (2020) · BMC Cancer · doi:10.1186/s12885-020-07307-0 · Cited by 18 · see citing works
Human age prediction based on DNA methylation of non-blood tissues
Xu, Y., Li, X., Yang, Y., Li, C., & Shao, X. (2019) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2019.02.010 · Cited by 18 · see citing works
BRM270 Inhibits the Proliferation of CD44 Positive Pancreatic Ductal Adenocarcinoma Cells via Downregulation of Sonic Hedgehog Signaling
Huynh, D. L., Koh, H., Chandimali, N., Zhang, J., Kim, N., Kang, T. Y., Ghosh, M., Gera, M., Park, Y.-H., Kwon, T., et al. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/8620469 · Cited by 18 · see citing works
The new advance of SALL4 in cancer: Function, regulation, and implication
Abouelnazar, F. A., Zhang, X., Wang, M., Zhang, J., Yu, D. B., Zang, X., Zhang, J., Li, Y., Xu, J., Yang, Q., et al. (2023) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24927 · Cited by 17 · see citing works
Knockdown of SALL4 inhibits the proliferation, migration, and invasion of human lung cancer cells in vivo and in vitro
Li, J., Zhang, Y., Tao, X., You, Q., Zheng, T., He, Z., & Ou, J. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-7939 · Cited by 16 · see citing works
The Pluripotency Network in Colorectal Cancer Pathogenesis and Prognosis: an Update
Voutsadakis, I. A. (2018) · Biomarkers in Medicine · doi:10.2217/bmm-2017-0369 · Cited by 16 · see citing works
Dual-Regulated Mechanism of EZH2 and KDM6A on SALL4 Modulates Tumor Progression via Wnt/β-Catenin Pathway in Gastric Cancer
Ren, L., Deng, H. X., Jiang, Y., & Liu, C. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-022-07790-4 · Cited by 15 · see citing works
Spalt-like transcription factor 4 as a potential diagnostic and prognostic marker of colorectal cancer
Wu, H., Liu, C., Xiao-xia, F., Wang, H., & Zhou, L. (2017) · Cancer Biomarkers · doi:10.3233/cbm-170204 · Cited by 15 · see citing works
In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis
Raos, D., Krasić, J., Mašić, S., Abramović, I., Ćorić, M., Krušlin, B., Bojanac, A. K., Bulić‐Jakuš, F., Ježek, D., Ulamec, M., et al. (2020) · Disease Markers · doi:10.1155/2020/8841880 · Cited by 14 · see citing works
Dysregulation of miR-638 in the progression of cancers
Chong, Z. X., Yeap, S. K., & Ho, W. Y. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153351 · Cited by 14 · see citing works
ChIP-AP: an integrated analysis pipeline for unbiased ChIP-seq analysis
Suryatenggara, J., Yong, K. J., Tenen, D. E., Tenen, D. G., & Bassal, M. A. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab537 · Cited by 14 · see citing works
Self-citation
Defining the Pluripotent Marker Genes for Identification of Teleost Fish Cell Pluripotency During Reprogramming
Li, H., Xu, W., Xiang, S., Tao, L., Fu, W., Liu, J., Liu, W., Xiao, Y., & Peng, L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.819682 · Cited by 14 · see citing works
The Nucleosome Remodeling and Deacetylase Complex in Development and Disease
Basta, J. M., & Rauchman, M. I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800802-7.00003-4 · Cited by 12 · see citing works
The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure
Wu, L., Zhao, G., Xu, S., Kuang, J., Jin, M., Wu, G., Wang, T., Wang, B., Zhu, P., Pei, D., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.014598 · Cited by 12 · see citing works
Ssu72-HNF4α signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma
Kim, H. S., Yoon, J.-S., Jeon, Y., Park, E., Lee, J., Chen, S., Lee, H., Park, J. Y., Go, H., & Lee, C. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00877-x · Cited by 12 · see citing works
A transcriptional network of cell cycle dysregulation in noninvasive papillary urothelial carcinoma
Warrick, J. I., Knowles, M. A., Hurst, C. D., Shuman, L., Raman, J. D., Walter, V., Putt, J., Dyrskjøt, L., Groeneveld, C. S., Castro, M. A. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-20927-9 · Cited by 10 · see citing works
SALL4 ‐related gene signature defines a specific stromal subset of pancreatic ductal adenocarcinoma with poor prognostic features
Vienot, A., Monnien, F., Truntzer, C., Mougey, V., Bouard, A., Pallandre, J., Molimard, C., Loyon, R., Asgarov, K., Avérous, G., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13370 · Cited by 11 · see citing works
Integrative Role of the SALL4 Gene: From Thalidomide Embryopathy to Genetic Defects of the Upper Limb, Internal Organs, Cerebral Midline, and Pituitary
Kodytková, A., Dušátková, P., Amaratunga, S. A., Plachý, L., Průhová, Š., & Lebl, J. (2023) · Hormone Research in Paediatrics · doi:10.1159/000531452 · Cited by 11 · see citing works
Genetic Analyses Identified a SALL4 Gene Mutation Associated with Holt–Oram Syndrome
Li, B., Chen, S., Sun, K., Xu, R., & Wu, Y. (2018) · DNA and Cell Biology · doi:10.1089/dna.2017.4094 · Cited by 10 · see citing works
Expression and clinical value of SALL4 in renal cell carcinomas
Che, J., Wu, P., Wang, G., Yao, X., Zheng, J., & Guo, C. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11170 · Cited by 10 · see citing works
SALL4 Phenotype in Four Generations of One Family: An Interplay of the Upper Limb, Kidneys, and the Pituitary
Kodytková, A., Amaratunga, S. A., Zemková, D., Maratová, K., Dušátková, P., Plachý, L., Průhová, Š., Koloušková, S., & Lebl, J. (2023) · Hormone Research in Paediatrics · doi:10.1159/000531996 · Cited by 9 · see citing works
SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms
Wang, T., Jin, Y., Wang, M., Chen, B., Sun, J., Zhang, J., Yang, H., Deng, X., Cao, X., Wang, L., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00812-z · Cited by 9 · see citing works
Thalidomide-induced limb malformations: an update and reevaluation
Collins, M. D., & Scott, W. J. (2025) · Archives of Toxicology · doi:10.1007/s00204-024-03930-z · Cited by 10 · see citing works
Isolation and Characterization of Human Colon Adenocarcinoma Stem-Like Cells Based on the Endogenous Expression of the Stem Markers
Koshkin, S. A., Anatskaya, O. V., Vinogradov, A. E., Uversky, V. N., Dayhoff, G. W., Bystriakova, M. A., Pospelov, V. A., & Tolkunova, E. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094682 · Cited by 9 · see citing works
Testicular Germ Cell Tumors: Serological and Immunohistochemical Diagnosis
Damjanov, I. (2021) · Acta Medica Academica · doi:10.5644/ama2006-124.326 · Cited by 9 · see citing works
Normal embryonic development and neonatal digit regeneration in mice overexpressing a stem cell factor, Sall4
Chen, K. Q., Anderson, A. M., Kawakami, H., Kim, J. S., Barrett, J., & Kawakami, Y. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267273 · Cited by 9 · see citing works
Long non-coding RNA ZEB2-AS1 regulates osteosarcoma progression by acting as a molecular sponge of miR-107 to modulate SALL4 expression.
Wang, Y., Liu, N., Li, M., & Du, M.-F. (2021) · PubMed Central · Cited by 9 · see citing works
Drugging the undruggable: Chemical and biological insights into molecular glues in the pipeline
Metwally, K. A., Yahya, G., & Abo-Dya, N. E. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.118132 · Cited by 8 · see citing works
Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence
Lakpour, N., Saliminejad, K., Ghods, R., Sadeghi, M. R., Pilatz, A. M. E., Khosravi, F., & Madjd, Z. (2021) · Andrologia · doi:10.1111/and.13998 · Cited by 8 · see citing works
SALL4 oncogene is an immunogenic antigen presented in various HLA-DR contexts
Kroemer, M., Spehner, L., Mercier‐Letondal, P., Boullerot, L., Kim, S. C. H., Jary, M., Galaine, J., Picard, E., Ferrand, C., Nguyen, T., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1412030 · Cited by 8 · see citing works
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Mehlferber, M., Kuyumcu‐Martinez, M. N., Miller, C. L., & Sheynkman, G. (2023) · Current Stem Cell Reports · doi:10.1007/s40778-023-00227-2 · Cited by 7 · see citing works
Overexpression of Sal-like protein 4 in head and neck cancer: epigenetic effects and clinical correlations
Misawa, K., Misawa, Y., Mima, M., Yamada, S., Imai, A., Mochizuki, D., Nakagawa, T., Kurokawa, T., Endo, S., Kawasaki, H., et al. (2020) · Cellular Oncology · doi:10.1007/s13402-020-00509-5 · Cited by 7 · see citing works
BEND3 promotes hepatocellular carcinoma progression and metastasis by activating the PI3K/AKT/mTOR pathway and inducing epithelial-mesenchymal transition
Yang, L.-L., Chen, X., Huang, K.-T., Tang, S.-T., Ye, G.-Y., & Wang, J. (2025) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2025.102582 · Cited by 6 · see citing works
Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal.
Kulkarni, S., Alampally, H., Guddattu, V., Rodrigues, G. S., & Carnelio, S. (2022) · F1000Research · doi:10.12688/f1000research.126091.1 · Cited by 6 · see citing works
Sall1 and Sall4 cooperatively interact with Myocd and SRF to promote cardiomyocyte proliferation by regulating CDK and cyclin genes
Katano, W., Mori, S., Sasaki, S., Tajika, Y., Tomita, K., Takeuchi, J., & Koshiba‐Takeuchi, K. (2023) · Development · doi:10.1242/dev.201913 · Cited by 6 · see citing works
Ku80 negatively regulates the expression of OCT4 via competitive binding to SALL4 and promoting lysosomal degradation of OCT4
Zhao, B., Zheng, X., Tan, X., Ke, K., Wang, F., Wang, Y., Xing, X., Zhang, C., Hu, P., Lan, S., et al. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105664 · Cited by 6 · see citing works
Role of SALL4 and Nodal in the prognosis and tamoxifen resistance of estrogen receptor-positive breast cancer.
Boustan, A., Mosaffa, F., Jahangiri, R., Miri, H. H., Ghalehno, A. D., & Jamialahmadi, K. (2021) · PubMed Central · doi:10.22099/mbrc.2021.39878.1597 · Cited by 6 · see citing works
SALL4/ABCB6 Axis Suppresses Ferroptosis in Colon Cancer by Mediating Mitophagy
Yang, L., Xu, Y., Han, J., Fang, C., Yang, Z., Zhang, R., & Zhou, S. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70183 · Cited by 5 · see citing works
A quantitative evaluation of topological motifs and their coupling in gene circuit state distributions
Clauss, B., & Lu, M. (2023) · iScience · doi:10.1016/j.isci.2023.106029 · Cited by 5 · see citing works
Maintenance and enhancement of human peripheral blood mobilized stem/progenitor cell engraftment after ex vivo culture via an HDACi/SALL4 axis (3465)
Tatetsu, H., Armant, M. A., Wang, F., Gao, C., Ueno, S., Tian, X., Alex Federation, Qi, J., Bradner, J. E., Tenen, D. G., et al. (2019) · Experimental Hematology · doi:10.1016/j.exphem.2019.06.473 · Cited by 5 · see citing works
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Dynamics of repair and regeneration of adult zebrafish respiratory gill tissue after cryoinjuryPreprint
Ramel, M., Progatzky, F., Rýdlová, A., Wane, M., Schymeinsky, J., Williams, C. M. M., Jung, B., Lamb, J. R., Thomas, M. J., Bugeon, L., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.27.445469 · Cited by 5 · see citing works
Targeting transcription factors through an IMiD independent zinc finger domain
Liu, B. H., Liu, M., Radhakrishnan, S., Dai, M.-Y., Jaladanki, C. K., Gao, C., Tang, J. P., Kumari, K., Go, M. L., Vu, K. A. L., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00241-3 · Cited by 8 · see citing works
“As a transcription factor, the uniqueness of SALL4 lies in the fact that it is expressed in embryonic cells, downregulated during development, absent in most adult tissues, and re-expressed in a signi ﬁ cant fraction of almost all human adult tumors (Moein et al, 2022; Tatetsu et al, 2016).”
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ADT increases prostate cancer cell invasion via altering AR/SALL4/SOX2-OCT4 stem cell signaling
Guo, C., Kadier, A., Zhang, Z., Huang, C., Mao, S., Yang, B., Zheng, J., & Yao, X. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10046-2 · Cited by 4 · see citing works
Differential expression of SALL4 in CTCs derived from hydatidiform moles and gestational trophoblastic neoplasms
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Stipoljev, F., Miric-Tesanic, D., Hafner, T., Barbalić, M., Logara, M., Lasan-Trčić, R., Vičić, A., & Juraški, R. G. (2017) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2017.08.010 · Cited by 4 · see citing works
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Miller, A., Gharbi, S., Dumeau, C.-É., Nishinakamura, R., & Hendrich, B. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/194852 · Cited by 4 · see citing works
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Lakpour, N., Ghods, R., Abolhasani, M., Zanjani, L. S., Saliminejad, K., Kalantari, E., Saki, S., Ranjbar, M. M., Balay‐Goli, L., Sadeghi, M. R., et al. (2024) · Biomarkers · doi:10.1080/1354750x.2024.2361796 · Cited by 3 · see citing works
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Liu, Y., Fabiani, E., Kwon, J., Gao, C., Falconi, G., Valentini, L., Gurnari, C., Liu, Y. V., Jones, A. I., Yang, J., et al. (2020) · medRxiv · doi:10.1101/2020.07.21.20157776 · Cited by 3 · see citing works
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Abu-Elmagd, M. M., Assidi, M., Alrefaei, A. F., & Rebaï, A. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1016400 · Cited by 3 · see citing works
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Moore, D., Wong, E., Arnal, C., Schoenfelder, S., Spivakov, M., Andrews, S., & Christophorou, M. A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.01.30.635440 · Cited by 3 · see citing works
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Demurtas, M., Barnada, S. M., van Domselaar, E., Mitchell, Z. H., Deelen, L., & Trizzino, M. (2025) · Development · doi:10.1242/dev.205248 · Cited by 2 · see citing works
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Lynch‐Sutherland, C. F., McDougall, L. I., Stockwell, P. A., Almomani, S. N., Weeks, R. J., Ludgate, J. L., Gamage, T. K. J. B., Chatterjee, A., James, J. L., Eccles, M. R., et al. (2023) · Molecular Genetics and Genomics · doi:10.1007/s00438-023-02033-1 · Cited by 2 · see citing works
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Naiyer, S., Dwivedi, L., Singh, N., Phulera, S., Mohan, V., & Kamran, M. Z. (2023) · Cancers · doi:10.3390/cancers15143685 · Cited by 2 · see citing works
Cell fate decision by a morphogen-transcription factor-chromatin modifier axis
Jin, M., Lin, L., Li, J., Wu, L., Fang, S., Huang, T., Fu, Y., Liu, D., Zhang, W., Li, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50144-z · Cited by 1 · see citing works
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Oya, S., Yoshida, H., Tomida, A., Miyachi, M., Yagyu, S., Katsumi, Y., Kikuchi, K., Tsuchiya, K., Konishi, E., Subramanian, S., et al. (2025) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-24-0710 · Cited by 1 · see citing works
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Authors: Tatetsu, H., Kong, N. R., Chong, G., Amabile, G., Tenen, D. G., & Chai, L.
Affiliations: Brigham and Women's Hospital (US)
Adienne (Switzerland) (CH)
Harvard University (US)
Corresponding author: Chai, Li
ORCID: Tatetsu, Hiro
Tenen, Daniel G.
Chai, Li
Venue: Gene
Publisher: Elsevier BV
Published: 2016-06
Volume: 584
Issue: 2
Pages: 111-119
ISSN: 0378-1119 (ISSN-L)
DOI: 10.1016/j.gene.2016.02.019
PMC: PMC4823161
OpenAlex: W2274155363
Cited by: 130
References: 152
Citations by year: 2026: 5 · 2025: 15 · 2024: 9 · 2023: 20 · 2022: 12 · 2021: 24 · 2020: 13 · 2019: 9 · 2018: 11 · 2017: 8 · 2016: 3 · 2014: 1
FWCI: 0.94
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gene (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (GM089820, P01HL095489, R03CA184531)
Ministry of Education - Singapore
V Foundation for Cancer Research
Leukemia and Lymphoma Society (SLP-8004-14, TRP-6482-16)
National Research Foundation
National Medical Research Council
Ministry of Health -Singapore
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords: SALL4, embryonic stem cells, cancer stem cells, carcinogenesis, cancer classification, targeted cancer therapy, cell fate regulation, developmental defects, gene expression signatures
MeSH terms: Humans, Neoplasms, Stem Cells, Transcription Factors

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SALL4, the missing link between stem cells, development and cancer

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