Melov, Simon

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

Li, Y., Huang, T.-T., Carlson, E. J., Melov, S., Ursell, P. C., Olson, J. L., Noble, L. J., Yoshimura, M. P., Berger, C., Chan, P. H., et al. (1995) · Nature Genetics

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 1,789

From discoveries in ageing research to therapeutics for healthy ageing

Campisi, J., Kapahi, P., Lithgow, G. J., Melov, S., Newman, J. C., & Verdin, E. (2019) · Nature

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 1,389

Cellular senescence promotes adverse effects of chemotherapy and cancer relapse

Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,338

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., & Campisi, J. (2003) · Nature Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 1,116

Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress

Lithgow, G. J., White, T. M., Melov, S., & Johnson, T. E. (1995) · Proceedings of the National Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsPhysiological and biochemical adaptations

Cited by 862

Mitochondrial disease in superoxide dismutase 2 mutant mice

Melov, S., Coskun, P., Patel, M., Tuinstra, R., Cottrell, B., Jun, A. S., Zastawny, T. H., Dizdaroglu, M., Goodman, S. I., Huang, T.-T., et al. (1999) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyMetabolism and Genetic Disorders

Cited by 581

Cellular senescence: a link between cancer and age-related degenerative disease?

Campisi, J., Andersen, J. K., Kapahi, P., & Melov, S. (2011) · Seminars in Cancer Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 421

SOD2 in mitochondrial dysfunction and neurodegeneration

Flynn, J. M., & Melov, S. (2013) · Free Radical Biology and Medicine

Glutathione Transferases and PolymorphismsMitochondrial Function and Pathology

Cited by 390

Mitochondrial Oxidative Stress Causes Hyperphosphorylation of Tau

Melov, S., Adlard, P. A., Morten, K., Johnson, F., Golden, T. R., Hinerfeld, D., Schilling, B., Mavros, C., Masters, C. L., Volitakis, I., et al. (2007) · PLoS ONE

Alzheimer's disease research and treatmentsMitochondrial Function and Pathology

Cited by 363

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin

Velarde, M. C., Flynn, J. M., Day, N. U., Melov, S., & Campisi, J. (2012) · Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 299

Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence

Wiley, C. D., Flynn, J. M., Morrissey, C., Lebofsky, R., Shuga, J., Dong, X., Unger, M. A., Vijg, J., Melov, S., & Campisi, J. (2017) · Aging Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 234

Suppressors of Superoxide-H 2 O 2 Production at Site I Q of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury

Brand, M. D., Goncalves, R. L. S., Orr, A. L., Vargas, L., Gerencser, A. A., Borch Jensen, M., Wang, Y. T., Melov, S., Turk, C. N., Matzen, J. T., et al. (2016) · Cell Metabolism

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 228

Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans

McColl, G., Killilea, D. W., Hubbard, A. E., Vantipalli, M. C., Melov, S., & Lithgow, G. J. (2008) · Journal of Biological Chemistry

Genetics, Aging, and Longevity in Model OrganismsEpigenetics and DNA Methylation

Cited by 202

Limb Immobilization Induces a Coordinate Down-Regulation of Mitochondrial and Other Metabolic Pathways in Men and Women

Abadi, A., Glover, E. I., Isfort, R. J., Raha, S., Safdar, A., Yasuda, N., Kaczor, J. J., Melov, S., Hubbard, A., Qu, X., et al. (2009) · PLoS ONE

Muscle Physiology and DisordersSpaceflight effects on biology

Cited by 189

Mitochondrial Oxidative Stress: Physiologic Consequences and Potential for a Role in Aging

MELOV, S. (2000) · Annals of the New York Academy of Sciences

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 161

Global and targeted gene expression and protein content in skeletal muscle of young men following short-term creatine monohydrate supplementation

Safdar, A., Yardley, N. J., Snow, R., Melov, S., & Tarnopolsky, M. A. (2008) · Physiological Genomics

Muscle metabolism and nutritionMuscle Physiology and Disorders

Cited by 149

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 122

Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts

Samper, E., Nicholls, D. G., & Melov, S. (2003) · Aging Cell

Mitochondrial Function and PathologyRedox biology and oxidative stress

Cited by 108

Translational Geroscience: Emphasizing function to achieve optimal longevity

Seals, D. R., & Melov, S. (2014) · Aging

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 90

Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment

Clayton, Z. S., Rossman, M. J., Mahoney, S. A., Venkatasubramanian, R., Maurer, G. S., Hutton, D. A., VanDongen, N. S., Greenberg, N. T., Longtine, A. G., Ludwig, K. R., et al. (2023) · Hypertension

Telomeres, Telomerase, and SenescenceCardiovascular Health and Disease Prevention

Cited by 84

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

Velarde, M. C., Demaria, M., Melov, S., & Campisi, J. (2015) · Proceedings of the National Academy of Sciences

Mitochondrial Function and PathologyTelomeres, Telomerase, and Senescence

Cited by 77

Science fact and the SENS agenda: What can we reasonably expect from ageing research?

Warner, H., Anderson, J., Austad, S., Bergamini, E., Bredesen, D., Butler, R., Carnes, B. A., Clark, B. F. C., Cristofalo, V., Faulkner, J., et al. (2005) · The EMBO Reports

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 74

Nigrostriatal Dopaminergic Neurodegeneration in the Weaver Mouse Is Mediated via Neuroinflammation and Alleviated by Minocycline Administration

Peng, J., Xie, L., Stevenson, F. F., Melov, S., Di Monte, D. A., & Andersen, J. K. (2006) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsParkinson's Disease Mechanisms and Treatments

Cited by 53

Advancing biological understanding of cellular senescence with computational multiomics

Li, S., Agudelo Garcia, P. A., Aliferis, C., Becich, M. J., Calyeca, J., Cosgrove, B. D., Elisseeff, J., Farzad, N., Fertig, E. J., Glass, C., et al. (2025) · Nature Genetics

Telomeres, Telomerase, and SenescenceSingle-cell and spatial transcriptomics

Cited by 40