Translational Geroscience: Emphasizing function to achieve optimal longevity
Open accessAbstract
Among individuals, biological aging leads to cellular and organismal dysfunction and an increased risk of chronic degenerative diseases and disability. This sequence of events in combination with the projected increases in the number of older adults will result in a worldwide healthcare burden with dire consequences. Superimposed on this setting are the adults now reaching traditional retirement ages--the baby boomers--a group that wishes to remain active, productive and physically and cognitively fit as they grow older. Together, these conditions are producing an unprecedented demand for increased healthspan or what might be termed "optimal longevity"-to live long, but well. To meet this demand, investigators with interests in the biological aspects of aging from model organisms to human epidemiology (population aging) must work together within an interactive process that we describe astranslational geroscience. An essential goal of this new investigational platform should be the optimization and preservation of physiological function throughout the lifespan, including integrative physical and cognitive function, which would serve to increase healthspan, compress morbidity and disability into a shorter period of late-life, and help achieve optimal longevity. To most effectively utilize this new approach, we must rethink how investigators and administrators working at different levels of the translational research continuum communicate and collaborate with each other, how best to train the next generation of scientists in this new field, and how contemporary biological-biomedical aging research should be organized and funded.
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Aging is a significant risk factor for functional decline, affective impairments, exaggerated response to illnesses, dementia, and overall vulnerability for diseases.
“Although aging is not a disease, it is a significant risk factor for functional decline, affective impairments, exaggerated response to illnesses, dementia, and overall vulnerability for diseases (Hayflick, 2007;Seals and Melov, 2014).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Seals and Melov, 2014
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- Authors
- Seals, D. R., & Melov, S.
- Affiliations
- University of Colorado Boulder (US)
- Buck Institute for Research on Aging (US)
- Corresponding author
- Seals, Douglas R.
- Venue
- Aging
- Publisher
- Impact Journals, LLC
- Published
- 2014-08-10
- Volume
- 6
- Issue
- 9
- Pages
- 718-730
- ISSN
- 1945-4589 (ISSN-L)
- PMC
- PMC4221919
- OpenAlex
- W172267094
- Cited by
- 90
- References
- 58
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 10 · 2019: 6 · 2018: 9 · 2017: 2 · 2016: 13 · 2015: 4
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Aging (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR001082)
- National Institute on Aging (R21AG042795, R37AG013038, AG042795, R01AG013038, AG-013038)
- National Heart, Lung, and Blood Institute (HL-107120, R01HL107120)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR063919, R21AR063919)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Social Sciences › Decision Sciences › Information Systems and Management › Interdisciplinary Research and Collaboration
- Keywords
- biological aging, healthspan, compression of morbidity, population aging, baby boomers, cognitive function, physical function, chronic degenerative diseases, disability, research collaboration, research funding, scientific training
- MeSH terms
- Animals, Geriatrics, Humans, Longevity, Translational Research, Biomedical
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