Bock, Christoph

Chromatin accessibility profiling methods

Minnoye, L., Marinov, G. K., Krausgruber, T., Pan, L., Marand, A. P., Secchia, S., Greenleaf, W. J., Furlong, E. E. M., Zhao, K., Schmitz, R. J., et al. (2021) · Nature Reviews Methods Primers

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 206

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

Dobbs, K., Domínguez Conde, C., Zhang, S.-Y., Parolini, S., Audry, M., Chou, J., Haapaniemi, E., Keles, S., Bilic, I., Okada, S., et al. (2015) · New England Journal of Medicine

Immunodeficiency and Autoimmune DisordersBlood disorders and treatments

Cited by 201

Multimodal analysis of cell-free DNA whole-genome sequencing for pediatric cancers with low mutational burden

Peneder, P., Stütz, A. M., Surdez, D., Krumbholz, M., Semper, S., Chicard, M., Sheffield, N. C., Pierron, G., Lapouble, E., Tötzl, M., et al. (2021) · Nature Communications

Cancer Genomics and DiagnosticsSarcoma Diagnosis and Treatment

Cited by 200

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses

Agerer, B., Koblischke, M., Gudipati, V., Montaño-Gutierrez, L. F., Smyth, M., Popa, A., Genger, J.-W., Endler, L., Florian, D. M., Mühlgrabner, V., et al. (2021) · Science Immunology

vaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Cited by 172

The organoid cell atlas

the Human Cell Atlas ‘Biological Network’ Organoids, Bock, C., Boutros, M., Camp, J. G., Clarke, L., Clevers, H., Knoblich, J. A., Liberali, P., Regev, A., Rios, A. C., et al. (2021) · Nature Biotechnology

Single-cell and spatial transcriptomicsPluripotent Stem Cells Research

Cited by 171

Comprehensive genome and epigenome characterization of CHO cells in response to evolutionary pressures and over time

Feichtinger, J., Hernández, I., Fischer, C., Hanscho, M., Auer, N., Hackl, M., Jadhav, V., Baumann, M., Krempl, P. M., Schmidl, C., et al. (2016) · Biotechnology and Bioengineering

Viral Infectious Diseases and Gene Expression in InsectsEpigenetics and DNA Methylation

Cited by 148

Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks

Rendeiro, A. F., Schmidl, C., Strefford, J. C., Walewska, R., Davis, Z., Farlik, M., Oscier, D., & Bock, C. (2016) · Nature Communications

Chronic Lymphocytic Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 146

Multi-omics of single cells: strategies and applications

Bock, C., Farlik, M., & Sheffield, N. C. (2016) · Trends in Biotechnology

Single-cell and spatial transcriptomicsBioinformatics and Genomic Networks

Cited by 146

Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data

Fortelny, N., & Bock, C. (2020) · Genome Biology

Bioinformatics and Genomic NetworksSingle-cell and spatial transcriptomics

Cited by 135

Temporal dissection of an enhancer cluster reveals distinct temporal and functional contributions of individual elements

Thomas, H. F., Kotova, E., Jayaram, S., Pilz, A., Romeike, M., Lackner, A., Penz, T., Bock, C., Leeb, M., Halbritter, F., et al. (2021) · Molecular Cell

Genomics and Chromatin DynamicsPluripotent Stem Cells Research

Cited by 98

The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen

Malta, T. M., Sabedot, T. S., Morosini, N. S., Datta, I., Garofano, L., Vallentgoed, W., Varn, F. S., Aldape, K., D'Angelo, F., Bakas, S., et al. (2024) · Cancer Research

Glioma Diagnosis and TreatmentEpigenetics and DNA Methylation

Cited by 68

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity

Salzer, E., Zoghi, S., Kiss, M. G., Kage, F., Rashkova, C., Stahnke, S., Haimel, M., Platzer, R., Caldera, M., Ardy, R. C., et al. (2020) · Science Immunology

T-cell and B-cell ImmunologySystemic Lupus Erythematosus Research

Cited by 48

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

Schmidl, C., Vladimer, G. I., Rendeiro, A. F., Schnabl, S., Krausgruber, T., Taubert, C., Krall, N., Pemovska, T., Araghi, M., Snijder, B., et al. (2019) · Nature Chemical Biology

Chronic Lymphocytic Leukemia ResearchLymphoma Diagnosis and Treatment

Cited by 39

Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation

Preglej, T., Hamminger, P., Luu, M., Bulat, T., Andersen, L., Göschl, L., Stolz, V., Rica, R., Sandner, L., Waltenberger, D., et al. (2020) · JCI Insight

T-cell and B-cell ImmunologyHistone Deacetylase Inhibitors Research

Cited by 36

Erratum to: Making sense of big data in health research: towards an EU action plan

Auffray, C., Balling, R., Barroso, I., Bencze, L., Benson, M., Bergeron, J., Bernal-Delgado, E., Blomberg, N., Bock, C., Conesa, A., et al. (2016) · Genome Medicine

Research Data Management PracticesBig Data Technologies and Applications

Cited by 29

Parallel reverse genetic screening in mutant human cells using transcriptomics

Gapp, B. V., Konopka, T., Penz, T., Dalal, V., Bürckstümmer, T., Bock, C., & Nijman, S. M. (2016) · Molecular Systems Biology

Genomics and Rare DiseasesBioinformatics and Genomic Networks

Cited by 12

Preserve personal freedom in networked societies

Bock, C. (2016) · Nature

Digitalization, Law, and RegulationLaw, Rights, and Freedoms

Cited by 8