Tainer, John A.

X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution

Putnam, C. D., Hammel, M., Hura, G. L., & Tainer, J. A. (2007) · Quarterly Reviews of Biophysics

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 1,184

Accurate assessment of mass, models and resolution by small-angle scattering

Rambo, R. P., & Tainer, J. A. (2013) · Nature

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 750

Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

Getzoff, E. D., Tainer, J. A., Weiner, P. K., Kollman, P. A., Richardson, J. S., & Richardson, D. C. (1983) · Nature

Protein Structure and DynamicsMetal-Catalyzed Oxygenation Mechanisms

Cited by 554

Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod‐Debye law

Rambo, R. P., & Tainer, J. A. (2011) · Biopolymers

Enzyme Structure and FunctionProtein Structure and Dynamics

Cited by 533

Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis

Collawn, J. F., Stangel, M., Kuhn, L. A., Esekogwu, V., Jing, S., Trowbridge, I. S., & Tainer, J. A. (1990) · Cell

Cellular transport and secretionProtein Structure and Dynamics

Cited by 518

The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles

Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Beyer, W. F., Hallewell, R. A., & Tainer, J. A. (1992) · Cell

Enzyme Structure and FunctionMetal-Catalyzed Oxygenation Mechanisms

Cited by 472

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.

Williams, R. S., Williams, J. S., & Tainer, J. A. (2007) · Biochemistry and Cell Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 399

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

Fan, L., Fuss, J. O., Cheng, Q. J., Arvai, A. S., Hammel, M., Roberts, V. A., Cooper, P. K., & Tainer, J. A. (2008) · Cell

DNA Repair MechanismsEnzyme Structure and Function

Cited by 369

Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair

Williams, R. S., Dodson, G. E., Limbo, O., Yamada, Y., Williams, J. S., Guenther, G., Classen, S., Glover, J. N. M., Iwasaki, H., Russell, P., et al. (2009) · Cell

DNA Repair MechanismsDNA and Nucleic Acid Chemistry

Cited by 322

The intricate structural chemistry of base excision repair machinery: Implications for DNA damage recognition, removal, and repair

Hitomi, K., Iwai, S., & Tainer, J. A. (2007) · DNA Repair

DNA Repair MechanismsEnzyme Structure and Function

Cited by 220

XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair

Hammel, M., Rey, M., Yu, Y., Mani, R. S., Classen, S., Liu, M., Pique, M. E., Fang, S., Mahaney, B. L., Weinfeld, M., et al. (2011) · Journal of Biological Chemistry

DNA Repair MechanismsEnzyme Structure and Function

Cited by 179

XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase

Fuss, J. O., & Tainer, J. A. (2011) · DNA Repair

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 170

Vitamin E enhances cancer immunotherapy by reinvigorating dendritic cells via targeting checkpoint SHP1.

Yuan, X., Duan, Y., Xiao, Y., Sun, K., Qi, Y., Zhang, Y., Ahmed, Z., Moiani, D., Yao, J., Li, H., et al. (2022) · Cancer Discovery

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 130

The role of arginine 143 in the electrostatics and mechanism of Cu, Zn superoxide dismutase: Computational and experimental evaluation by mutational analysis

Fisher, C. L., Cabelli, D. E., Tainer, J. A., Hallewell, R. A., & Getzoff, E. D. (1994) · Proteins: Structure, Function, and Bioinformatics

Metal-Catalyzed Oxygenation MechanismsProtein Structure and Dynamics

Cited by 125

XLF regulates filament architecture of the XRCC4.ligase IV complex

Hammel, M., Yu, Y., Fang, S., Lees-Miller, S. P., & Tainer, J. A. (2010) · Structure

DNA Repair MechanismsEnzyme Structure and Function

Cited by 116

N‐terminal domain swapping and metal ion binding in nitric oxide synthase dimerization

Crane, B. R., Rosenfeld, R. J., Arvai, A. S., Ghosh, D. K., Ghosh, S., Tainer, J. A., Stuehr, D. J., & Getzoff, E. D. (1999) · The EMBO Journal

Nitric Oxide and Endothelin EffectsEnzyme Structure and Function

Cited by 110

Perchlorate Reductase Is Distinguished by Active Site Aromatic Gate Residues

Youngblut, M. D., Tsai, C.-L., Clark, I. C., Carlson, H. K., Maglaqui, A. P., Gau-Pan, P. S., Redford, S. A., Wong, A., Tainer, J. A., & Coates, J. D. (2016) · Journal of Biological Chemistry

Chemical Analysis and Environmental ImpactEnzyme Structure and Function

Cited by 88

Aberrant RNA methylation triggers recruitment of an alkylation repair complex

Tsao, N., Brickner, J. R., Rodell, R., Ganguly, A., Wood, M., Oyeniran, C., Ahmad, T., Sun, H., Bacolla, A., Zhang, L., et al. (2021) · Molecular Cell

DNA Repair MechanismsRNA regulation and disease

Cited by 46

A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy

Townley, B. A., Buerer, L., Tsao, N., Bacolla, A., Mansoori, F., Rusanov, T., Clark, N. E., Goodarzi, N., Schmidt, N., Srivatsan, S. N., et al. (2023) · Molecular Cell

RNA Research and SplicingRNA and protein synthesis mechanisms

Cited by 15