Penning, Trevor M.

Multiple steps determine the overall rate of the reduction of 5α-dihydrotestosterone catalyzed by human type 3 3α-hydroxysteroid dehydrogenase: implications for the elimination of androgens

Jin, Y., & Penning, T. M. (2006) · Biochemistry

Aldose Reductase and TaurinePhysical Organic Chemistry and Reaction Kinetics

Cited by 60

Elucidation of a Complete Kinetic Mechanism for a Mammalian Hydroxysteroid Dehydrogenase (HSD) and Identification of All Enzyme Forms on the Reaction Coordinate

Cooper, W. C., Jin, Y., & Penning, T. M. (2007) · Journal of Biological Chemistry

Physical Organic Chemistry and Reaction KineticsAldose Reductase and Taurine

Cited by 58

Deoxycorticosterone inactivation by AKR1C3 in human mineralocorticoid target tissues

Sharma, K. K., Lindqvist, A., Zhou, X. J., Auchus, R. J., Penning, T. M., & Andersson, S. (2006) · Molecular and Cellular Endocrinology

Hormonal Regulation and HypertensionAldose Reductase and Taurine

Cited by 57

5β-Reduced steroids and human Δ4-3-ketosteroid 5β-reductase (AKR1D1)

Chen, M., & Penning, T. M. (2014) · Steroids

Steroid Chemistry and BiochemistryAldose Reductase and Taurine

Cited by 55

Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)

Chen, M., Drury, J. E., & Penning, T. M. (2011) · Steroids

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 53

Characterization of disease-related 5β-reductase (AKR1D1) mutations reveals their potential to cause bile acid deficiency

Drury, J. E., Mindnich, R., & Penning, T. M. (2010) · Journal of Biological Chemistry

Metabolism and Genetic DisordersAldose Reductase and Taurine

Cited by 51

New frontiers in androgen biosynthesis and metabolism

Penning, T. M. (2010) · Current Opinion in Endocrinology, Diabetes & Obesity

Prostate Cancer Treatment and ResearchHormonal and reproductive studies

Cited by 51

Human Cytosolic Hydroxysteroid Dehydrogenases of the Aldo-ketoreductase Superfamily Catalyze Reduction of Conjugated Steroids

Jin, Y., Duan, L., Lee, S. H., Kloosterboer, H. J., Blair, I. A., & Penning, T. M. (2009) · Journal of Biological Chemistry

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 50

Human hydroxysteroid dehydrogenases and pre-receptor regulation: Insights into inhibitor design and evaluation

Penning, T. M. (2011) · The Journal of Steroid Biochemistry and Molecular Biology

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 50

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo–keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway

Jin, Y., Mesaros, A. C., Blair, I. A., & Penning, T. M. (2011) · Biochemical Journal

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 49

Molecular docking simulations of steroid substrates into human cytosolic hydroxysteroid dehydrogenases (AKR1C1 and AKR1C2): insights into positional and stereochemical preferences

Jin, Y., & Penning, T. M. (2006) · Steroids

Computational Drug Discovery MethodsSteroid Chemistry and Biochemistry

Cited by 37

Simultaneous quantitation of nine hydroxy-androgens and their conjugates in human serum by stable isotope dilution liquid chromatography electrospray ionization tandem mass spectrometry

Zang, T., Tamae, D., Mesaros, C., Wang, Q., Huang, M., Blair, I. A., & Penning, T. M. (2017) · The Journal of Steroid Biochemistry and Molecular Biology

Prostate Cancer Treatment and ResearchMass Spectrometry Techniques and Applications

Cited by 29

Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo–keto reductase superfamily

Jin, Y., Duan, L., Chen, M., Penning, T. M., & Kloosterboer, H. J. (2012) · The Journal of Steroid Biochemistry and Molecular Biology

Aldose Reductase and TaurinePharmacogenetics and Drug Metabolism

Cited by 18

The effect of disease associated point mutations on 5β-reductase (AKR1D1) enzyme function

Mindnich, R., Drury, J. E., & Penning, T. M. (2011) · Chemico-Biological Interactions

Aldose Reductase and TaurineSteroid Chemistry and Biochemistry

Cited by 16

Contribution of mouse adrenal glands to intratumor androgens and growth of castration-resistant prostate cancer xenografts

Mostaghel, E. A., Biehl, H., Hernandez, S., Zhang, A., Bartlett, J., Corey, E., Penning, T. M., Oksala, R., True, L. D., & Nelson, P. (2017) · Journal of Clinical Oncology

Prostate Cancer Treatment and ResearchAdrenal Hormones and Disorders

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