Hummer, Gerhard

Coarse master equations for peptide folding dynamics

Buchete, N.-V., & Hummer, G. (2008) · The Journal of Physical Chemistry B

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 477

Artificial intelligence reveals nuclear pore complexity

Mosalaganti, S., Obarska-Kosinska, A., Siggel, M., Turonova, B., Zimmerli, C. E., Buczak, K., Schmidt, F. H., Margiotta, E., Mackmull, M.-T., Hagen, W., et al. (2021) · Science

Nuclear Structure and FunctionProtein Structure and Dynamics

Cited by 355

AI-based structure prediction empowers integrative structural analysis of human nuclear pores

Mosalaganti, S., Obarska-Kosinska, A., Siggel, M., Taniguchi, R., Turoňová, B., Zimmerli, C. E., Buczak, K., Schmidt, F. H., Margiotta, E., Mackmull, M.-T., et al. (2022) · Science

Nuclear Structure and FunctionProtein Structure and Dynamics

Cited by 355

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation

Gruijs da Silva, L. A., Simonetti, F., Hutten, S., Riemenschneider, H., Sternburg, E. L., Pietrek, L. M., Gebel, J., Dötsch, V., Edbauer, D., Hummer, G., et al. (2022) · The EMBO Journal

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 192

Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Pandi, A., Adam, D., Zare, A., Trinh, V. T., Schaefer, S. L., Burt, M., Klabunde, B., Bobkova, E., Kushwaha, M., Foroughijabbari, Y., et al. (2023) · Nature Communications

Antimicrobial Peptides and ActivitiesChemical Synthesis and Analysis

Cited by 173

Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides

Pandi, A., Adam, D., Zare, A., Trinh, V. T., Schaefer, S. L., Wiegand, M., Klabunde, B., Bobkova, E., Kushwaha, M., Foroughijabbari, Y., et al. (2022) · Nature Communications

Antimicrobial Peptides and ActivitiesChemical Synthesis and Analysis

Cited by 173

Intrinsic map dynamics exploration for uncharted effective free-energy landscapes

Chiavazzo, E., Covino, R., Coifman, R. R., Gear, C. W., Georgiou, A. S., Hummer, G., & Kevrekidis, I. G. (2017) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 125

Peptide folding kinetics from replica exchange molecular dynamics

Buchete, N.-V., & Hummer, G. (2008) · Physical Review E

Protein Structure and DynamicsAdvanced Physical and Chemical Molecular Interactions

Cited by 121

Structural basis of p38α regulation by hematopoietic tyrosine phosphatase

Francis, D. M., Różycki, B., Koveal, D., Hummer, G., Page, R., & Peti, W. (2011) · Nature Chemical Biology

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 79

Osh Proteins Control Nanoscale Lipid Organization Necessary for PI(4,5)P2 Synthesis

Nishimura, T., Gecht, M., Covino, R., Hummer, G., Surma, M. A., Klose, C., Arai, H., Kono, N., & Stefan, C. J. (2019) · Molecular Cell

Lipid Membrane Structure and BehaviorCellular transport and secretion

Cited by 56

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery

Adriaenssens, E., Schaar, S., Cook, A. S. I., Stuke, J. F. M., Sawa-Makarska, J., Nguyen, T. N., Ren, X., Schuschnig, M., Romanov, J., Khuu, G., et al. (2025) · Nature Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 53

Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery

Adriaenssens, E., Schaar, S., Cook, A. S. I., Stuke, J. F. M., Sawa-Makarska, J., Nguyen, T. N., Ren, X., Schuschnig, M., Romanov, J., Khuu, G., et al. (2024) · Nature Cell Biology

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 53

Crosstalk between regulatory elements in disordered TRPV4 N-terminus modulates lipid-dependent channel activity

Goretzki, B., Wiedemann, C., McCray, B. A., Schäfer, S. L., Jansen, J., Tebbe, F., Mitrovic, S.-A., Nöth, J., Cabezudo, A. C., Donohue, J. K., et al. (2023) · Nature Communications

Ion Channels and ReceptorsProtein Structure and Dynamics

Cited by 51

Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery

Jensen, L. E., Rao, S., Schuschnig, M., Cada, A. K., Martens, S., Hummer, G., & Hurley, J. H. (2022) · Science Advances

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 49

Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore

Rao, S., Skulsuppaisarn, M., Strong, L. M., Ren, X., Lazarou, M., Hurley, J. H., & Hummer, G. (2024) · Science Advances

Autophagy in Disease and TherapyUbiquitin and proteasome pathways

Cited by 40

Structural pathway for PI3-kinase regulation by VPS15 in autophagy

Cook, A. S. I., Chen, M., Nguyen, T. N., Cabezudo, A. C., Khuu, G., Rao, S., Garcia, S. N., Yang, M., Iavarone, A. T., Ren, X., et al. (2025) · Science

Autophagy in Disease and TherapyCellular transport and secretion

Cited by 34

Resting and Active States of the ERK2:HePTP Complex

Francis, D. M., Różycki, B., Tortajada, A., Hummer, G., Peti, W., & Page, R. (2011) · Journal of the American Chemical Society

Protein Tyrosine PhosphatasesProtein Structure and Dynamics

Cited by 32

Evidence for a trap-and-flip mechanism in a proton-dependent lipid transporter

Lambert, E., Mehdipour, A. R., Schmidt, A., Hummer, G., & Perez, C. (2022) · Nature Communications

Drug Transport and Resistance MechanismsLipid Membrane Structure and Behavior

Cited by 24

TriMem: A parallelized hybrid Monte Carlo software for efficient simulations of lipid membranes

Siggel, M., Kehl, S., Reuter, K., Köfinger, J., & Hummer, G. (2022) · The Journal of Chemical Physics

Lipid Membrane Structure and BehaviorAdvanced Physical and Chemical Molecular Interactions

Cited by 22

Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy

Poveda-Cuevas, S. A., Lohachova, K., Dikic, I., Hummer, G., & Bhaskara, R. M. (2024) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsLipid Membrane Structure and Behavior

Cited by 18

Intrinsically disordered region amplifies membrane remodeling to augment selective ER-phagy

Poveda-Cuevas, S. A., Lohachova, K., Markusic, B., Dikic, I., Hummer, G., & Bhaskara, R. M. (2024) · Proceedings of the National Academy of Sciences

Protein Structure and DynamicsLipid Membrane Structure and Behavior

Cited by 18

AlphaFold2 SLiM screen for LC3-LIR interactions in autophagy

Stuke, J. F. M., & Hummer, G. (2025) · Autophagy

Autophagy in Disease and TherapyProtein Structure and Dynamics

Cited by 8

AlphaFold modeling of polyubiquitin complexes and covalently linked proteins

Fábián, B., Stuke, J. F. M., Heinz, M., & Hummer, G. (2025) · Cell Reports Physical Science

Protein Structure and DynamicsUbiquitin and proteasome pathways

Cited by 3