Rabinovitch, Peter S.

Extension of murine life span by overexpression of catalase targeted to mitochondria

Schriner, S. E., Linford, N. J., Martin, G. M., Treuting, P., Ogburn, C. E., Emond, M., Coskun, P. E., Ladiges, W., Wolf, N., Van Remmen, H., et al. (2005) · Science

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 1,724

mTOR is a key modulator of ageing and age-related disease

Johnson, S. C., Rabinovitch, P. S., & Kaeberlein, M. (2013) · Nature

Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancer

Cited by 1,676

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

Anderson, E. J., Lustig, M. E., Boyle, K. E., Woodlief, T. L., Kane, D. A., Lin, C.-T., Price, J. W., Kang, L., Rabinovitch, P. S., Szeto, H. H., et al. (2009) · Journal of Clinical Investigation

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 1,253

Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

Dai, D.-F., Johnson, S. C., Villarin, J. J., Chin, M. T., Nieves-Cintrón, M., Chen, T., Marcinek, D. J., Dorn, G. W., Kang, Y. J., Prolla, T. A., et al. (2011) · Circulation Research

Mitochondrial Function and PathologyCardiac Fibrosis and Remodeling

Cited by 527

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Vermulst, M., Wanagat, J., Kujoth, G. C., Bielas, J. H., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2008) · Nature Genetics

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 411

Mitochondrial point mutations do not limit the natural lifespan of mice

Vermulst, M., Bielas, J. H., Kujoth, G. C., Ladiges, W. C., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2007) · Nature Genetics

Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and Pathology

Cited by 404

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C–Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

Ramos, F. J., Chen, S. C., Garelick, M. G., Dai, D.-F., Liao, C.-Y., Schreiber, K. H., MacKay, V. L., An, E. H., Strong, R., Ladiges, W. C., et al. (2012) · Science Translational Medicine

Nuclear Structure and FunctionMuscle Physiology and Disorders

Cited by 349

Chromosomal instability in ulcerative colitis is related to telomere shortening

O'Sullivan, J. N., Bronner, M. P., Brentnall, T. A., Finley, J. C., Shen, W.-T., Emerson, S., Emond, M. J., Gollahon, K. A., Moskovitz, A. H., Crispin, D. A., et al. (2002) · Nature Genetics

Telomeres, Telomerase, and SenescenceInflammatory Bowel Disease

Cited by 346

Healthy aging: The ultimate preventative medicine

Kaeberlein, M., Rabinovitch, P. S., & Martin, G. M. (2015) · Science

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 341

Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease

Dai, D.-F., Chen, T., Johnson, S. C., Szeto, H., & Rabinovitch, P. S. (2012) · Antioxidants & Redox Signaling

Cardiovascular Function and Risk FactorsGenetics, Aging, and Longevity in Model Organisms

Cited by 334

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance

Lee, H.-Y., Choi, C. S., Birkenfeld, A. L., Alves, T. C., Jornayvaz, F. R., Jurczak, M. J., Zhang, D., Woo, D. K., Shadel, G. S., Ladiges, W., et al. (2010) · Cell Metabolism

Mitochondrial Function and PathologyAdipose Tissue and Metabolism

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Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria

Dai, D., Chen, T., Wanagat, J., Laflamme, M., Marcinek, D. J., Emond, M. J., Ngo, C. P., Prolla, T. A., & Rabinovitch, P. S. (2010) · Aging Cell

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 280

Mitochondrial proteome remodelling in pressure overload-induced heart failure: the role of mitochondrial oxidative stress

Dai, D.-F., Hsieh, E. J., Liu, Y., Chen, T., Beyer, R. P., Chin, M. T., MacCoss, M. J., & Rabinovitch, P. S. (2012) · Cardiovascular Research

Mitochondrial Function and PathologyCardiac Ischemia and Reperfusion

Cited by 178

Molecular mechanisms underlying genotype‐dependent responses to dietary restriction

Schleit, J., Johnson, S. C., Bennett, C. F., Simko, M., Trongtham, N., Castanza, A., Hsieh, E. J., Moller, R. M., Wasko, B. M., Delaney, J. R., et al. (2013) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

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Rapamycin transiently induces mitochondrial remodeling to reprogram energy metabolism in old hearts

Chiao, Y. A., Kolwicz, S. C., Basisty, N., Gagnidze, A., Zhang, J., Gu, H., Djukovic, D., Beyer, R. P., Raftery, D., MacCoss, M., et al. (2016) · Aging

Autophagy in Disease and TherapyMitochondrial Function and Pathology

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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

SenNet Consortium, Writing Group, Lee, P. J., Benz, C. C., Blood, P., Börner, K., Campisi, J., Chen, F., Daldrup-Link, H., De Jager, P., et al. (2022) · Nature Aging

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

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Lifespan extension in genetically modified mice

Ladiges, W., Van Remmen, H., Strong, R., Ikeno, Y., Treuting, P., Rabinovitch, P., & Richardson, A. (2009) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 101

Measures of Healthspan as Indices of Aging in Mice—A Recommendation

Richardson, A., Fischer, K. E., Speakman, J. R., de Cabo, R., Mitchell, S. J., Peterson, C. A., Rabinovitch, P., Chiao, Y. A., Taffet, G., Miller, R. A., et al. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

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The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging

Sanchez-Contreras, M., Sweetwyne, M. T., Tsantilas, K. A., Whitson, J. A., Campbell, M. D., Kohrn, B. F., Kim, H. J., Hipp, M. J., Fredrickson, J., Nguyen, M. M., et al. (2023) · eLife

Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model Organisms

Cited by 71

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet–Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Lee, H.-Y., Lee, J. S., Alves, T., Ladiges, W., Rabinovitch, P. S., Jurczak, M. J., Choi, C. S., Shulman, G. I., & Samuel, V. T. (2017) · Diabetes

Metabolism, Diabetes, and CancerAdipose Tissue and Metabolism

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Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age

Roeder, S. S., Stefanska, A., Eng, D. G., Kaverina, N., Sunseri, M. W., McNicholas, B. A., Rabinovitch, P., Engel, F. B., Daniel, C., Amann, K., et al. (2015) · American Journal of Physiology-Renal Physiology

Chronic Kidney Disease and DiabetesRenal Diseases and Glomerulopathies

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