Healthy aging: The ultimate preventative medicine
Open accessAbstract
Age is the greatest risk factor for nearly every major cause of mortality in developed nations. Despite this, most biomedical research focuses on individual disease processes without much consideration for the relationships between aging and disease. Recent discoveries in the field of geroscience, which aims to explain biological mechanisms of aging, have provided insights into molecular processes that underlie biological aging and, perhaps more importantly, potential interventions to delay aging and promote healthy longevity. Here we describe some of these advances, along with efforts to move geroscience from the bench to the clinic. We also propose that greater emphasis should be placed on research into basic aging processes, because interventions that slow aging will have a greater effect on quality of life compared with disease-specific approaches.
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Aging affects all organ systems through shared mechanisms including immune changes, oxidative stress, DNA damage, epigenetic changes, and abnormal protein accumulation.
“Aging affects all organ systems through common underlying mechanisms such as changes in the immune system, oxidative stress, and DNA damage and replication errors, as well as epigenetic changes and accumulation of abnormal proteins across multiple organ systems.35–38”
From Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (2017) · cites this paper as [36]
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- Authors
- Kaeberlein, M., Rabinovitch, P. S., & Martin, G. M.
- Affiliations
- University of Washington (US)
- University of California, Los Angeles (US)
- Corresponding author
- Kaeberlein, Matt
- Venue
- Science
- Published
- 2015-12-04
- Volume
- 350
- Issue
- 6265
- Pages
- 1191-1193
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4793924
- OpenAlex
- W2262829592
- Cited by
- 341
- References
- 39
- Citations by year
- 2026: 38 · 2025: 36 · 2024: 37 · 2023: 30 · 2022: 28 · 2021: 22 · 2020: 30 · 2019: 24 · 2018: 40 · 2017: 35 · 2016: 20
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIA (P30AG013280)
- Basic Biology of Aging
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- healthy aging, geroscience, biological aging, aging interventions, healthy longevity, age-related diseases, translational research, quality of life, mortality risk
- MeSH terms
- Aging, Animals, Diet, Geriatrics, Health, Humans, Mortality, Preventive Medicine, Risk Factors, Exercise, Translational Research, Biomedical, TOR Serine-Threonine Kinases
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