Hsu, Patrick D.

Multiplex Genome Engineering Using CRISPR/Cas Systems

Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 15,339

Genome engineering using the CRISPR-Cas9 system

Ran, F. A., Hsu, P. D., Wright, J., Agarwala, V., Scott, D. A., & Zhang, F. (2013) · Nature Protocols

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 11,133

Development and Applications of CRISPR-Cas9 for Genome Engineering

Hsu, P. D., Lander, E. S., & Zhang, F. (2014) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 5,762

DNA targeting specificity of RNA-guided Cas9 nucleases

Hsu, P. D., Scott, D. A., Weinstein, J. A., Ran, F. A., Konermann, S., Agarwala, V., Li, Y., Fine, E. J., Wu, X., Shalem, O., et al. (2013) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 4,741

Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

Ran, F. A., Hsu, P. D., Lin, C.-Y., Gootenberg, J. S., Konermann, S., Trevino, A. E., Scott, D. A., Inoue, A., Matoba, S., Zhang, Y., et al. (2013) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 3,299

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., Hsu, P. D., Habib, N., Gootenberg, J. S., Nishimasu, H., et al. (2015) · Nature

CRISPR and Genetic EngineeringChromatin Remodeling and Cancer

Cited by 2,825

Crystal structure of Cas9 in complex with guide RNA and target DNA

Nishimasu, H., Ran, F. A., Hsu, P. D., Konermann, S., Shehata, S. I., Dohmae, N., Ishitani, R., Zhang, F., & Nureki, O. (2014) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,306

Transcriptome Engineering with RNA-Targeting Type VI-D CRISPR Effectors

Konermann, S., Lotfy, P., Brideau, N. J., Oki, J., Shokhirev, M. N., & Hsu, P. D. (2018) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,164

Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells

Wu, X., Scott, D. A., Kriz, A. J., Chiu, A. C., Hsu, P. D., Dadon, D. B., Cheng, A. W., Trevino, A. E., Konermann, S., Chen, S., et al. (2014) · Nature Biotechnology

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 944

Simulating 500 million years of evolution with a language model

Hayes, T., Rao, R., Akin, H., Sofroniew, N. J., Oktay, D., Lin, Z., Verkuil, R., Tran, V. Q., Deaton, J., Wiggert, M., et al. (2025) · Science

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 937

Optical control of mammalian endogenous transcription and epigenetic states

Konermann, S., Brigham, M. D., Trevino, A. E., Hsu, P. D., Heidenreich, M., Cong, L., Platt, R. J., Scott, D. A., Church, G. M., & Zhang, F. (2013) · Nature

Photoreceptor and optogenetics researchCRISPR and Genetic Engineering

Cited by 803

Sequence modeling and design from molecular to genome scale with Evo

Nguyen, E., Poli, M., Durrant, M. G., Thomas, A. W., Kang, B., Sullivan, J., Ng, M. Y., Lewis, A., Patel, A., Lou, A., et al. (2024) · Science

Genomics and Phylogenetic StudiesMachine Learning in Bioinformatics

Cited by 592

Sequence modeling and design from molecular to genome scale with Evo

Nguyen, E., Poli, M., Durrant, M. G., Kang, B., Katrekar, D., Li, D. B., Bartie, L. J., Thomas, A. W., King, S. H., Brixi, G., et al. (2024) · Science

Genomics and Phylogenetic StudiesMachine Learning in Bioinformatics

Cited by 580

Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d

Zhang, C., Konermann, S., Brideau, N. J., Lotfy, P., Wu, X., Novick, S. J., Strutzenberg, T., Griffin, P. R., Hsu, P. D., & Lyumkis, D. (2018) · Cell

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 276

Bridge RNAs direct programmable recombination of target and donor DNA

Durrant, M. G., Perry, N. T., Pai, J. J., Jangid, A. R., Athukoralage, J. S., Hiraizumi, M., McSpedon, J. P., Pawluk, A., Nishimasu, H., Konermann, S., et al. (2024) · Nature

CRISPR and Genetic EngineeringBacterial Genetics and Biotechnology

Cited by 163

Predicting cellular responses to perturbation across diverse contexts with State

Adduri, A. K., Gautam, D., Bevilacqua, B., Naghipourfar, M., Imran, A., Shah, R., Teyssier, N., Verma, R., Carpenter, C., Eraslan, B., et al. (2026) · Cell

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 100

Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting

Wei, J., Lotfy, P., Faizi, K., Baungaard, S., Gibson, E., Wang, E., Slabodkin, H., Kinnaman, E., Chandrasekaran, S., Kitano, H., et al. (2021) · Cell Systems

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 67