Itoh, Ken

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 3,999

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 3,634

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M., & Talalay, P. (2002) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,947

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

McMahon, M., Itoh, K., Yamamoto, M., & Hayes, J. D. (2003) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressRedox biology and oxidative stress

Cited by 1,141

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

Ramos-Gomez, M., Kwak, M.-K., Dolan, P. M., Itoh, K., Yamamoto, M., Talalay, P., & Kensler, T. W. (2001) · Proceedings of the National Academy of Sciences

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 1,102

Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

Tong, K. I., Katoh, Y., Kusunoki, H., Itoh, K., Tanaka, T., & Yamamoto, M. (2006) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressProtein Structure and Dynamics

Cited by 759

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice

CHANAS, S. A., JIANG, Q., McMAHON, M., McWALTER, G. K., McLELLAN, L. I., ELCOMBE, C. R., HENDERSON, C. J., WOLF, C. R., MOFFAT, G. J., ITOH, K., et al. (2002) · Biochemical Journal

Genomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 460

Transcription Factor Nrf2 Regulates Inflammation by Mediating the Effect of 15-Deoxy-Δ12,14-Prostaglandin J2

Itoh, K., Mochizuki, M., Ishii, Y., Ishii, T., Shibata, T., Kawamoto, Y., Kelly, V., Sekizawa, K., Uchida, K., & Yamamoto, M. (2004) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressHeme Oxygenase-1 and Carbon Monoxide

Cited by 407

Accelerated DNA adduct formation in the lung of the Nrf2 knockout mouse exposed to diesel exhaust

Aoki, Y., Sato, H., Nishimura, N., Takahashi, S., Itoh, K., & Yamamoto, M. (2001) · Toxicology and Applied Pharmacology

Carcinogens and Genotoxicity AssessmentGenomics, phytochemicals, and oxidative stress

Cited by 297

Transcription factor Nrf2 plays a pivotal role in protection against elastase-induced pulmonary inflammation and emphysema

Ishii, Y., Itoh, K., Morishima, Y., Kimura, T., Kiwamoto, T., IIzuka, T., Hegab, A. E., Hosoya, T., Nomura, A., Sakamoto, T., et al. (2005) · The Journal of Immunology

Genomics, phytochemicals, and oxidative stressChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 248

BRG1 Interacts with Nrf2 To Selectively Mediate HO-1 Induction in Response to Oxidative Stress

Zhang, J., Ohta, T., Maruyama, A., Hosoya, T., Nishikawa, K., Maher, J. M., Shibahara, S., Itoh, K., & Yamamoto, M. (2006) · Molecular and Cellular Biology

Genomics, phytochemicals, and oxidative stressHeme Oxygenase-1 and Carbon Monoxide

Cited by 213

Proteinase K-resistant α-synuclein is deposited in presynapses in human Lewy body disease and A53T α-synuclein transgenic mice

Tanji, K., Mori, F., Mimura, J., Itoh, K., Kakita, A., Takahashi, H., & Wakabayashi, K. (2010) · Acta Neuropathologica

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 102

Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases

Tanji, K., Maruyama, A., Odagiri, S., Mori, F., Itoh, K., Kakita, A., Takahashi, H., & Wakabayashi, K. (2013) · Journal of Neuropathology & Experimental Neurology

Genomics, phytochemicals, and oxidative stressParkinson's Disease Mechanisms and Treatments

Cited by 80

Emerging Role of GCN1 in Disease and Homeostasis

Tatara, Y., Kasai, S., Kokubu, D., Tsujita, T., Mimura, J., & Itoh, K. (2024) · International Journal of Molecular Sciences

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 16

Emerging Role of GCN1 in Disease and Homeostasis

Tatara, Y., Kasai, S., Kokubu, D., Tsujita, T., Mimura, J., & Itoh, K. (2024) · International Journal of Molecular Sciences

RNA and protein synthesis mechanismsPI3K/AKT/mTOR signaling in cancer

Cited by 16