Yokoyama, Jennifer S.

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

Desikan, R. S., Fan, C. C., Wang, Y., Schork, A. J., Cabral, H. J., Cupples, L. A., Thompson, W. K., Besser, L., Kukull, W. A., Holland, D., et al. (2017) · PLoS Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 395

Exome sequencing identifies rare damaging variants in ATP8B4 and ABCA1 as risk factors for Alzheimer’s disease

Holstege, H., Hulsman, M., Charbonnier, C., Grenier-Boley, B., Quenez, O., Grozeva, D., van Rooij, J. G. J., Sims, R., Ahmad, S., Amin, N., et al. (2022) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 226

Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion

Khan, B. K., Yokoyama, J. S., Takada, L. T., Sha, S. J., Rutherford, N. J., Fong, J. C., Karydas, A. M., Wu, T., Ketelle, R. S., Baker, M. C., et al. (2012) · Journal of Neurology, Neurosurgery & Psychiatry

Amyotrophic Lateral Sclerosis ResearchDementia and Cognitive Impairment Research

Cited by 185

Association between genetic traits for immune-mediated diseases and Alzheimer disease

Yokoyama, J. S., Wang, Y., Schork, A. J., Thompson, W. K., Karch, C. M., Cruchaga, C., McEvoy, L. K., Witoelar, A., Chen, C.-H., Holland, D., et al. (2016) · JAMA Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 176

A second X chromosome contributes to resilience in a mouse model of Alzheimer’s disease

Davis, E. J., Broestl, L., Abdulai-Saiku, S., Worden, K., Bonham, L. W., Miñones-Moyano, E., Moreno, A. J., Wang, D., Chang, K., Williams, G., et al. (2020) · Science Translational Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 176

Dissecting the clinical heterogeneity of early-onset Alzheimer’s disease

Sirkis, D. W., Bonham, L. W., Johnson, T. P., La Joie, R., & Yokoyama, J. S. (2022) · Molecular Psychiatry

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 151

Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer’s disease

Broce, I. J., Tan, C. H., Fan, C. C., Jansen, I., Savage, J. E., Witoelar, A., Wen, N., Hess, C. P., Dillon, W. P., Glastonbury, C. M., et al. (2019) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 140

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

Moguilner, S., Baez, S., Hernandez, H., Migeot, J., Legaz, A., Gonzalez-Gomez, R., Farina, F. R., Prado, P., Cuadros, J., Tagliazucchi, E., et al. (2024) · Nature Medicine

Dementia and Cognitive Impairment ResearchFunctional Brain Connectivity Studies

Cited by 128

Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture

Miller, Z. A., Sturm, V. E., Camsari, G. B., Karydas, A., Yokoyama, J. S., Grinberg, L. T., Boxer, A. L., Rosen, H. J., Rankin, K. P., Gorno-Tempini, M. L., et al. (2016) · Neurology Neuroimmunology & Neuroinflammation

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 100

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia

International FTD-Genomics Consortium (IFGC), Yokoyama, J. S., Karch, C. M., Fan, C. C., Bonham, L. W., Kouri, N., Ross, O. A., Rademakers, R., Kim, J., Wang, Y., et al. (2017) · Acta Neuropathologica

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cited by 99

Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case–control study

Steele, N. Z. R., Carr, J. S., Bonham, L. W., Geier, E. G., Damotte, V., Miller, Z. A., Desikan, R. S., Boehme, K. L., Mukherjee, S., Crane, P. K., et al. (2017) · PLOS Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 91

Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum

Karch, C. M., Wen, N., Fan, C. C., Yokoyama, J. S., Kouri, N., Ross, O. A., Höglinger, G., Müller, U., Ferrari, R., Hardy, J., et al. (2018) · JAMA Neurology

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 89

The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

Bonham, L. W., Sirkis, D. W., & Yokoyama, J. S. (2019) · Frontiers in Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 83

Damage to left frontal regulatory circuits produces greater positive emotional reactivity in frontotemporal dementia

Sturm, V. E., Yokoyama, J. S., Eckart, J. A., Zakrzewski, J., Rosen, H. J., Miller, B. L., Seeley, W. W., & Levenson, R. W. (2015) · Cortex

Neural and Behavioral Psychology StudiesDementia and Cognitive Impairment Research

Cited by 65

Rare TREM2 variants associated with Alzheimer’s disease display reduced cell surface expression

Sirkis, D. W., Bonham, L. W., Aparicio, R. E., Geier, E. G., Ramos, E. M., Wang, Q., Karydas, A., Miller, Z. A., Miller, B. L., Coppola, G., et al. (2016) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 61

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy

Alquezar, C., Schoch, K. M., Geier, E. G., Ramos, E. M., Scrivo, A., Li, K. H., Argouarch, A. R., Mlynarski, E. E., Dombroski, B., DeTure, M., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 56

Educational disparities in brain health and dementia across Latin America and the United States

Gonzalez‐Gomez, R., Legaz, A., Moguilner, S., Cruzat, J., Hernández, H., Baez, S., Cocchi, R., Coronel‐Olivero, C., Medel, V., Tagliazuchi, E., et al. (2024) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchCognitive Abilities and Testing

Cited by 55

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia

Geier, E. G., Bourdenx, M., Storm, N. J., Cochran, J. N., Sirkis, D. W., Hwang, J.-H., Bonham, L. W., Ramos, E. M., Diaz, A., Van Berlo, V., et al. (2019) · Acta Neuropathologica

Alzheimer's disease research and treatmentsLysosomal Storage Disorders Research

Cited by 39

Structural inequality linked to brain volume and network dynamics in aging and dementia across the Americas

Legaz, A., Altschuler, F., Gonzalez-Gomez, R., Hernández, H., Baez, S., Migeot, J., Fittipaldi, S., Medel, V., Maito, M. A., Godoy, M. E., et al. (2024) · Nature Aging

Dementia and Cognitive Impairment ResearchHealth disparities and outcomes

Cited by 36

Decision tree analysis of genetic risk for clinically heterogeneous Alzheimer’s disease

Yokoyama, J. S., Bonham, L. W., Sears, R. L., Klein, E., Karydas, A., Kramer, J. H., Miller, B. L., & Coppola, G. (2015) · BMC Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 28

Immunological signatures in frontotemporal lobar degeneration

Sirkis, D. W., Bonham, L. W., Karch, C. M., & Yokoyama, J. S. (2019) · Current Opinion in Neurology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 14

Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer’s disease

Bonham, L. W., Sirkis, D. W., Fan, J., Aparicio, R. E., Tse, M., Ramos, E. M., Wang, Q., Coppola, G., Rosen, H. J., Miller, B. L., et al. (2017) · Neurocase

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 10

Differences in peripheral immune system gene expression in frontotemporal degeneration

Sawyer, R. P., Hill, E. J., Yokoyama, J., Medvedovic, M., Ren, Y., Zhang, X., Choubey, D., Shatz, R. S., Miller, B., & Woo, D. (2022) · Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 9