Lee, Edward B.

BACE overexpression alters the subcellular processing of APP and inhibits Aβ deposition in vivo

Lee, E. B., Zhang, B., Liu, K., Greenbaum, E. A., Doms, R. W., Trojanowski, J. Q., & Lee, V. M.-Y. (2005) · The Journal of Cell Biology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 140

Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases

Kovacs, G. G., Robinson, J. L., Xie, S. X., Lee, E. B., Grossman, M., Wolk, D. A., Irwin, D. J., Weintraub, D., Kim, C. F., Schuck, T., et al. (2017) · Journal of Neuropathology & Experimental Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 132

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

Pottier, C., Zhou, X., Perkerson, R. B., Baker, M., Jenkins, G. D., Serie, D. J., Ghidoni, R., Benussi, L., Binetti, G., López de Munain, A., et al. (2018) · The Lancet Neurology

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 131

Obesity, leptin, and Alzheimer's disease

Lee, E. B. (2011) · Annals of the New York Academy of Sciences

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 126

Multisite assessment of NIA‐AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., et al. (2016) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 113

Multimodal evaluation demonstrates in vivo 18F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration

McMillan, C. T., Irwin, D. J., Nasrallah, I., Phillips, J. S., Spindler, M., Rascovsky, K., Ternes, K., Jester, C., Wolk, D. A., Kwong, L. K., et al. (2016) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 87

Resolving tissue complexity by multimodal spatial omics modeling with MISO

Coleman, K., Schroeder, A., Loth, M., Zhang, D., Park, J. H., Sung, J.-Y., Blank, N., Cowan, A. J., Qian, X., Chen, J., et al. (2025) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 87

Human Alzheimer’s disease reactive astrocytes exhibit a loss of homeostastic gene expression

Dai, D. L., Li, M., & Lee, E. B. (2023) · Acta Neuropathologica Communications

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 77

Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease

Phillips, J. S., Da Re, F., Dratch, L., Xie, S. X., Irwin, D. J., McMillan, C. T., Vaishnavi, S. N., Ferrarese, C., Lee, E. B., Shaw, L. M., et al. (2018) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 74

A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes

Lleó, A., Irwin, D. J., Illán-Gala, I., McMillan, C. T., Wolk, D. A., Lee, E. B., Van Deerlin, V. M., Shaw, L. M., Trojanowski, J. Q., & Grossman, M. (2018) · JAMA Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 71

Ante mortem cerebrospinal fluid tau levels correlate with postmortem tau pathology in frontotemporal lobar degeneration

Irwin, D. J., Lleó, A., Xie, S. X., McMillan, C. T., Wolk, D. A., Lee, E. B., Van Deerlin, V. M., Shaw, L. M., Trojanowski, J. Q., & Grossman, M. (2017) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 67

Alzheimer disease biomarkers: moving from CSF to plasma for reliable detection of amyloid and tau pathology

Kang, J. H., Korecka, M., Lee, E. B., Cousins, K. A. Q., Tropea, T. F., Chen-Plotkin, A. A., Irwin, D. J., Wolk, D., Brylska, M., Wan, Y., et al. (2023) · Clinical Chemistry

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 64

Large‐scale deep proteomic analysis in Alzheimer's disease brain regions across race and ethnicity

Seifar, F., Fox, E. J., Shantaraman, A., Liu, Y., Dammer, E. B., Modeste, E., Duong, D. M., Yin, L., Trautwig, A. N., Guo, Q., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 52

Cerebrospinal fluid α‐synuclein contributes to the differential diagnosis of Alzheimer's disease

Shi, M., Tang, L., Toledo, J. B., Ginghina, C., Wang, H., Aro, P., Jensen, P. H., Weintraub, D., Chen‐Plotkin, A. S., Irwin, D. J., et al. (2018) · Alzheimer's & Dementia

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 42

Bridging the gap: Multi‐omics profiling of brain tissue in Alzheimer's disease and older controls in multi‐ethnic populations

Reddy, J. S., Heath, L., Linden, A. V., Allen, M., Lopes, K. D. P., Seifar, F., Wang, E., Ma, Y., Poehlman, W. L., Quicksall, Z. S., et al. (2024) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 29

CSF Biomarkers of Alzheimer Disease in Patients With Concomitant α-Synuclein Pathology

Cousins, K. A. Q., Arezoumandan, S., Shellikeri, S., Ohm, D., Shaw, L. M., Grossman, M., Wolk, D., McMillan, C. T., Chen-Plotkin, A., Lee, E., et al. (2022) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 25

Multimarker synaptic protein cerebrospinal fluid panels reflect TDP-43 pathology and cognitive performance in a pathological cohort of frontotemporal lobar degeneration

Cervantes González, A., Irwin, D. J., Alcolea, D., McMillan, C. T., Chen-Plotkin, A., Wolk, D., Sirisi, S., Dols-Icardo, O., Querol-Vilaseca, M., Illán-Gala, I., et al. (2022) · Molecular Neurodegeneration

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

Cited by 19

Comparison of the amyloid plaque proteome in Down syndrome, early‐onset Alzheimer's disease, and late‐onset Alzheimer's disease

Martá-Ariza, M., Leitner, D. F., Kanshin, E., Suazo, J., Giusti Pedrosa, A., Thierry, M., Lee, E. B., Devinsky, O., Drummond, E., Fortea, J., et al. (2025) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 15

Natural speech markers of Alzheimer's disease co-pathology in Lewy body dementias

Shellikeri, S., Cho, S., Cousins, K. A. Q., Liberman, M., Howard, E., Balganorth, Y., Weintraub, D., Spindler, M., Deik, A., Lee, E. B., et al. (2022) · Parkinsonism & Related Disorders

Dementia and Cognitive Impairment ResearchVoice and Speech Disorders

Cited by 12

Neuroanatomical and cellular degeneration associated with a social disorder characterized by new ritualistic belief systems in a TDP-C patient vs. a Pick patient

Ohm, D. T., Rhodes, E., Bahena, A., Capp, N., Lowe, M., Sabatini, P., Trotman, W., Olm, C. A., Phillips, J., Prabhakaran, K., et al. (2023) · Frontiers in Neurology

Dementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

Cited by 6