Cited by 42Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

Cerebrospinal fluid α‐synuclein contributes to the differential diagnosis of Alzheimer's disease

Open access
Shi, Min, Tang, Lu, Toledo, Jon B., Ginghina, Carmen, Wang, Hua, Aro, Patrick, Jensen, Poul H., Weintraub, Daniel +10 more·2018·Alzheimer's & Dementia

Abstract

Introduction: The ability of Alzheimer's disease (AD) cerebrospinal fluid (CSF) biomarkers (amyloid β peptide 1–42, total tau, and phosphorylated tau) to discriminate AD from related disorders is limited. Biomarkers for other concomitant pathologies (e.g., CSF α‐synuclein [α‐syn] for Lewy body pathology) may be needed to further improve the differential diagnosis. Methods: CSF total α‐syn, phosphorylated α‐syn at Ser129, and AD CSF biomarkers were evaluated with Luminex immunoassays in 367 participants, followed by validation in 74 different neuropathologically confirmed cases. Results: CSF total α‐syn, when combined with amyloid β peptide 1–42 and either total tau or phosphorylated tau, improved the differential diagnosis of AD versus frontotemporal dementia, Lewy body disorders, or other neurological disorders. The diagnostic accuracy of the combined models attained clinical relevance (area under curve ∼0.9) and was largely validated in neuropathologically confirmed cases. Discussion: Combining CSF biomarkers representing AD and Lewy body pathologies may have clinical value in the differential diagnosis of AD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.jalz.2018.02.015

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Numerous studies have documented unaltered or slightly increased cerebrospinal fluid αSyn levels in patients with mild cognitive impairment and Alzheimer's disease.

    “numerous studies have documented unaltered or slightly increased CSF αSyn levels in patients with MCI and AD [27, 80–82, 86, 90, 91, 93, 94].”

    From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [94]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Shi, M., Tang, L., Toledo, J. B., Ginghina, C., Wang, H., Aro, P., Jensen, P. H., Weintraub, D., Chen‐Plotkin, A. S., Irwin, D. J., Grossman, M., McCluskey, L., Elman, L. B., Wolk, D. A., Lee, E. B., Shaw, L. M., Trojanowski, J. Q., & Zhang, J.
Affiliations
  • University of Washington (US)
  • University of Pennsylvania (US)
  • Department of Pathology University of Washington School of Medicine Seattle WA USA
  • Aarhus University (DK)
Corresponding author
Zhang, Jing
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2018-03-28
Volume
14
Issue
8
Pages
1052-1062
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2795342522
Cited by
42
References
58
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 9 · 2018: 5
FWCI
5.08
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (U01 NS082137, U01 NS091272, R56 AG057417, P30 AG010124, P50 NS053488, P01 AG017586-8499)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
Alzheimer's disease, cerebrospinal fluid biomarkers
MeSH terms
Aged, Alzheimer Disease, Amyloid, Diagnosis, Differential, Female, Humans, Male, Phosphorylation, Biomarkers, tau Proteins, Lewy Body Disease, alpha-Synuclein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review