Lee, Edward B.

New insights into the genetic etiology of Alzheimer’s disease and related dementias

Bellenguez, C., Küçükali, F., Jansen, I. E., Kleineidam, L., Moreno-Grau, S., Amin, N., Naj, A. C., Campos-Martin, R., Grenier-Boley, B., Andrade, V., et al. (2022) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 2,498

SpaGCN: Integrating gene expression, spatial location and histology to identify spatial domains and spatially variable genes by graph convolutional network

Hu, J., Li, X., Coleman, K., Schroeder, A., Ma, N., Irwin, D. J., Lee, E. B., Shinohara, R. T., & Li, M. (2021) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,113

Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis

Brettschneider, J., Del Tredici, K., Toledo, J. B., Robinson, J. L., Irwin, D. J., Grossman, M., Suh, E., Van Deerlin, V. M., Wood, E. M., Baek, Y., et al. (2013) · Annals of Neurology

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 1,065

Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Johnson, E. C. B., Dammer, E. B., Duong, D. M., Ping, L., Zhou, M., Yin, L., Higginbotham, L. A., Guajardo, A., White, B., Troncoso, J. C., et al. (2020) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 1,001

Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated

Robinson, J. L., Lee, E. B., Xie, S. X., Rennert, L., Suh, E., Bredenberg, C., Caswell, C., Van Deerlin, V. M., Yan, N., Yousef, A., et al. (2018) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 729

Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration

Lee, E. B., Lee, V. M.-Y., & Trojanowski, J. Q. (2012) · Nature Reviews Neuroscience

Amyotrophic Lateral Sclerosis ResearchHereditary Neurological Disorders

Cited by 659

Aging-related tau astrogliopathy (ARTAG): Harmonized evaluation strategy

Kovacs, G. G., Ferrer, I., Grinberg, L. T., Alafuzoff, I., Attems, J., Budka, H., Cairns, N. J., Crary, J. F., Duyckaerts, C., Ghetti, B., et al. (2016) · Acta Neuropathologica

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 532

Distribution patterns of tau pathology in progressive supranuclear palsy

Kovacs, G. G., Lukic, M. J., Irwin, D. J., Arzberger, T., Respondek, G., Lee, E. B., Coughlin, D., Giese, A., Grossman, M., Kurz, C., et al. (2020) · Acta Neuropathologica

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

Cited by 483

Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

Zhang, B., Maiti, A., Shively, S., Lakhani, F., McDonald-Jones, G., Bruce, J., Lee, E. B., Xie, S. X., Joyce, S., Li, C., et al. (2005) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsMicrotubule and mitosis dynamics

Cited by 413

Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Tam, O. H., Rozhkov, N. V., Shaw, R., Kim, D., Hubbard, I., Fennessey, S., Propp, N., Phatnani, H., Kwan, J., Sareen, D., et al. (2019) · Cell Reports

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 327

C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD

O’Rourke, J. G., Bogdanik, L., Muhammad, A. K. M. G., Gendron, T. F., Kim, K. J., Austin, A., Cady, J., Liu, E. Y., Zarrow, J., Grant, S., et al. (2015) · Neuron

Amyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative Diseases

Cited by 298

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

Porta, S., Xu, Y., Restrepo, C. R., Kwong, L. K., Zhang, B., Brown, H. J., Lee, E. B., Trojanowski, J. Q., & Lee, V. M.-Y. (2018) · Nature Communications

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 248

APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease

Nguyen, A. T., Wang, K., Hu, G., Wang, X., Miao, Z., Azevedo, J. A., Suh, E., Van Deerlin, V. M., Choi, D., Roeder, K., et al. (2020) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 241

TDP-43 depletion in microglia promotes amyloid clearance but also induces synapse loss

Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S., Lee, V. M.-Y., et al. (2017) · Neuron

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 239

A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank

Toledo, J. B., Van Deerlin, V. M., Lee, E. B., Suh, E., Baek, Y., Robinson, J. L., Xie, S. X., McBride, J., Wood, E. M., Schuck, T., et al. (2014) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 234

Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons

Liu, E. Y., Russ, J., Cali, C. P., Phan, J. M., Amlie-Wolf, A., & Lee, E. B. (2019) · Cell Reports

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

Cited by 231

Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology

Zhang, D., Schroeder, A., Yan, H., Yang, H., Hu, J., Lee, M. Y. Y., Cho, K. S., Susztak, K., Xu, G. X., Feldman, M. D., et al. (2024) · Nature Biotechnology

Single-cell and spatial transcriptomicsCell Image Analysis Techniques

Cited by 219

The development and convergence of co-pathologies in Alzheimer’s disease

Robinson, J. L., Richardson, H., Xie, S. X., Suh, E., Van Deerlin, V. M., Alfaro, B., Loh, N., Porras-Paniagua, M., Nirschl, J. J., Wolk, D., et al. (2021) · Brain

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 203

Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology

Toledo, J. B., Gopal, P., Raible, K., Irwin, D. J., Brettschneider, J., Sedor, S., Waits, K., Boluda, S., Grossman, M., Van Deerlin, V. M., et al. (2016) · Acta Neuropathologica

Parkinson's Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Cited by 184

C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD

Liu, E. Y., Russ, J., Wu, K., Neal, D., Suh, E., McNally, A. G., Irwin, D. J., Van Deerlin, V. M., & Lee, E. B. (2014) · Acta Neuropathologica

Amyotrophic Lateral Sclerosis ResearchEpigenetics and DNA Methylation

Cited by 180

GPNMB confers risk for Parkinson’s disease through interaction with α-synuclein

Diaz-Ortiz, M. E., Seo, Y., Posavi, M., Carceles Cordon, M., Clark, E., Jain, N., Charan, R., Gallagher, M. D., Unger, T. L., Amari, N., et al. (2022) · Science

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 158

Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players

Lee, E. B., Kinch, K., Johnson, V. E., Trojanowski, J. Q., Smith, D. H., & Stewart, W. (2019) · Acta Neuropathologica

Traumatic Brain Injury ResearchDementia and Cognitive Impairment Research

Cited by 157

Perforant path synaptic loss correlates with cognitive impairment and Alzheimer’s disease in the oldest-old

Robinson, J. L., Molina-Porcel, L., Corrada, M. M., Raible, K., Lee, E. B., Lee, V. M.-Y., Kawas, C. H., & Trojanowski, J. Q. (2014) · Brain

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 157

Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia

Giannini, L. A. A., Irwin, D. J., McMillan, C. T., Ash, S., Rascovsky, K., Wolk, D. A., Van Deerlin, V. M., Lee, E. B., Trojanowski, J. Q., & Grossman, M. (2017) · Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 144