Palecek, Sean P.

Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions

Lian, X., Zhang, J., Azarin, S. M., Zhu, K., Hazeltine, L. B., Bao, X., Hsiao, C., Kamp, T. J., & Palecek, S. P. (2013) · Nature Protocols

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 1,748

Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling

Lian, X., Hsiao, C., Wilson, G., Zhu, K., Hazeltine, L. B., Azarin, S. M., Raval, K. K., Zhang, J., Kamp, T. J., & Palecek, S. P. (2012) · Proceedings of the National Academy of Sciences

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 1,717

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

Lippmann, E. S., Azarin, S. M., Kay, J. E., Nessler, R. A., Wilson, H. K., Al-Ahmad, A., Palecek, S. P., & Shusta, E. V. (2012) · Nature Biotechnology

Barrier Structure and Function StudiesPluripotent Stem Cells Research

Cited by 800

A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources

Lippmann, E. S., Al-Ahmad, A., Azarin, S. M., Palecek, S. P., & Shusta, E. V. (2014) · Scientific Reports

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 508

Regulation of Cell Migration by the Calcium-dependent Protease Calpain

Huttenlocher, A., Palecek, S. P., Lu, Q., Zhang, W., Mellgren, R. L., Lauffenburger, D. A., Ginsberg, M. H., & Horwitz, A. F. (1997) · Journal of Biological Chemistry

Calpain Protease Function and RegulationCell Adhesion Molecules Research

Cited by 390

Directed differentiation of human pluripotent stem cells to blood-brain barrier endothelial cells

Qian, T., Maguire, S. E., Canfield, S. G., Bao, X., Olson, W. R., Shusta, E. V., & Palecek, S. P. (2017) · Science Advances

Barrier Structure and Function StudiesPluripotent Stem Cells Research

Cited by 254

An isogenic blood–brain barrier model comprising brain endothelial cells, astrocytes, and neurons derived from human induced pluripotent stem cells

Canfield, S. G., Stebbins, M. J., Morales, B. S., Asai, S. W., Vatine, G. D., Svendsen, C. N., Palecek, S. P., & Shusta, E. V. (2017) · Journal of Neurochemistry

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 250

Modeling Psychomotor Retardation using iPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier

Vatine, G. D., Al-Ahmad, A., Barriga, B. K., Svendsen, S., Salim, A., Garcia, L., Garcia, V. J., Ho, R., Yucer, N., Qian, T., et al. (2017) · Cell Stem Cell

Barrier Structure and Function StudiesPluripotent Stem Cells Research

Cited by 233

Human pluripotent stem cell–derived brain pericyte–like cells induce blood-brain barrier properties

Stebbins, M. J., Gastfriend, B. D., Canfield, S. G., Lee, M.-S., Richards, D., Faubion, M. G., Li, W.-J., Daneman, R., Palecek, S. P., & Shusta, E. V. (2019) · Science Advances

Barrier Structure and Function StudiesPluripotent Stem Cells Research

Cited by 195

Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells

Stebbins, M. J., Wilson, H. K., Canfield, S. G., Qian, T., Palecek, S. P., & Shusta, E. V. (2016) · Methods

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 179

Chemically defined, albumin-free human cardiomyocyte generation

Lian, X., Bao, X., Zilberter, M., Westman, M., Fisahn, A., Hsiao, C., Hazeltine, L. B., Dunn, K. K., Kamp, T. J., & Palecek, S. P. (2015) · Nature Methods

Pluripotent Stem Cells ResearchCongenital heart defects research

Cited by 159

Exploring the effects of cell seeding density on the differentiation of human pluripotent stem cells to brain microvascular endothelial cells

Wilson, H. K., Canfield, S. G., Hjortness, M. K., Palecek, S. P., & Shusta, E. V. (2015) · Fluids and Barriers of the CNS

Barrier Structure and Function StudiesPluripotent Stem Cells Research

Cited by 130

Inhibition of Focal Adhesion Kinase Signaling by Integrin α6β1 Supports Human Pluripotent Stem Cell Self-Renewal

Villa-Diaz, L. G., Kim, J. K., Laperle, A., Palecek, S. P., & Krebsbach, P. H. (2016) · Stem Cells

Pluripotent Stem Cells ResearchCell Adhesion Molecules Research

Cited by 77

A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

Grancharova, T., Gerbin, K. A., Rosenberg, A. B., Roco, C. M., Arakaki, J. E., DeLizo, C. M., Dinh, S. Q., Donovan-Maiye, R. M., Hirano, M., Nelson, A. M., et al. (2021) · Scientific Reports

Pluripotent Stem Cells ResearchSingle-cell and spatial transcriptomics

Cited by 61

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

Gerbin, K. A., Grancharova, T., Donovan-Maiye, R., Hendershott, M. C., Brown, J., Dinh, S. Q., Gehring, J. L., Hirano, M., Johnson, G. R., Nath, A., et al. (2020) · Cell Systems

Single-cell and spatial transcriptomicsPluripotent Stem Cells Research

Cited by 59

Engineering Scalable Manufacturing of High-Quality Stem Cell-Derived Cardiomyocytes for Cardiac Tissue Repair

Dunn, K. K., & Palecek, S. P. (2018) · Frontiers in Medicine

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 41

Cryopreservation of Brain Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Is Enhanced by Rho-Associated Coiled Coil-Containing Kinase Inhibition

Wilson, H. K., Faubion, M. G., Hjortness, M. K., Palecek, S. P., & Shusta, E. V. (2016) · Tissue Engineering Part C: Methods

Barrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

Cited by 29

Pericytes Enrich the Basement Membrane and Reduce Neutrophil Transmigration in an In Vitro Model of Peripheral Inflammation at the Blood–Brain Barrier

McCloskey, M. C., Ahmad, S. D., Widom, L. P., Kasap, P., Gastfriend, B. D., Shusta, E. V., Palecek, S. P., Engelhardt, B., Gaborski, T. R., Flax, J., et al. (2024) · Biomaterials Research

Barrier Structure and Function Studies3D Printing in Biomedical Research

Cited by 16