Regulation of Cell Migration by the Calcium-dependent Protease Calpain

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New era of calpain research

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Dicistronic transcription units for gene expression in mammalian cells

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Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit

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Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytoskeletal Attachment of Integrin αIIbβ3 (Platelet Glycoprotein IIb/IIIa) and the Cellular Retraction of Fibrin Clots

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Involvement of Calpain in Integrin-Mediated Signal Transduction

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Inhibition of Growth of Human TE2 and C-33A Cells by the Cell-Permeant Calpain Inhibitor Benzyloxycarbonyl-Leu-Leu-Tyr Diazomethyl Ketone

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Isolation of a Chinese Hamster Ovary Cell Clone Possessing Decreased µ-Calpain Content and a Reduced Proliferative Growth Rate

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The Calpain System

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MAP kinases and cell migration

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Focal adhesion regulation of cell behavior

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Integrins in Cell MigrationPreprint

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Adhesion assembly, disassembly and turnover in migrating cells – over and over and over again

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Calpain-mediated proteolysis of talin regulates adhesion dynamics

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The interplay between Src and integrins in normal and tumor biology

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Regulating cell migration: calpains make the cut

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Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1

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Cell Migration

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The calpain system and cancer

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Regulation of cell movement is mediated by stretch-activated calcium channels

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Cutting to the chase: calpain proteases in cell motility

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The Role of HDAC6 in Cancer

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Cell Migration--Movin' On

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Signaling Networks that Regulate Cell MigrationPreprint

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Disruption of the Murine Calpain Small Subunit Gene, Capn4 : Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division

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Calpain Activation in Huntington's Disease

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Tumor Invasion: Role of Growth Factor-Induced Cell Motility

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Regulation of actin-based cell migration by cAMP/PKA

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v-SRC'S hold over actin and cell adhesions

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Transcription Factor Pax5 Activates the Chromatin of Key Genes Involved in B Cell Signaling, Adhesion, Migration, and Immune Function

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Integrin-mediated Adhesion Regulates Cell Polarity and Membrane Protrusion through the Rho Family of GTPases

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Role of mitogen-activated protein kinase kinase kinases in signal integration

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Calpain Regulates Actin Remodeling during Cell Spreading

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Epidermal Growth Factor Activates m-Calpain (Calpain II), at Least in Part, by Extracellular Signal-Regulated Kinase-Mediated Phosphorylation

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Forces on adhesive contacts affect cell function

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Epidermal Growth Factor Receptor Activation of Calpain Is Required for Fibroblast Motility and Occurs via an ERK/MAP Kinase Signaling Pathway

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TRPM7 Regulates Cell Adhesion by Controlling the Calcium-dependent Protease Calpain

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Membrane Proximal ERK Signaling Is Required for M-calpain Activation Downstream of Epidermal Growth Factor Receptor Signaling

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Regulation of focal complex composition and disassembly by the calcium-dependent protease calpain

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Synaptic evidence for the efficacy of spaced learning

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Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion

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Calpain Function in the Modulation of Signal Transduction Molecules

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Calcium Rises Locally Trigger Focal Adhesion Disassembly and Enhance Residency of Focal Adhesion Kinase at Focal Adhesions

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Tumor invasion as dysregulated cell motility

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Calpain 2 and Src dependence distinguishes mesenchymal and amoeboid modes of tumour cell invasion: a link to integrin function

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TRPC1 regulates skeletal myoblast migration and differentiation

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Filopodial Calcium Transients Regulate Growth Cone Motility and Guidance through Local Activation of Calpain

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Apicomplexan Parasites Co-Opt Host Calpains to Facilitate Their Escape from Infected Cells

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The regulation of integrin function by Ca2+

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m-Calpain is required for preimplantation embryonic development in mice

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Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain

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Calpain: a role in cell transformation and migration

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Epidermal Growth Factor Induces Fibroblast Contractility and Motility via a Protein Kinase C δ-dependent Pathway

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Calpain regulates neutrophil chemotaxis

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Cell migration: mechanisms of rear detachment and the formation of migration tracks

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Ip-10 Inhibits Epidermal Growth Factor–Induced Motility by Decreasing Epidermal Growth Factor Receptor–Mediated Calpain Activity

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Hepatocyte growth factor and Madin-Darby canine kidney cells: In vitro models of epithelial cell movement and morphogenesis

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Cleavage of Focal Adhesion Kinase by Different Proteases during Src-regulated Transformation and Apoptosis

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Growth Factor-Induced Cell Motility in Tumor Invasion

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RACK1 Regulates Integrin-mediated Adhesion, Protrusion, and Chemotactic Cell Migration via Its Src-binding Site

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Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

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Genome-Wide Association Study for Identifying Loci that Affect Fillet Yield, Carcass, and Body Weight Traits in Rainbow Trout (Oncorhynchus mykiss)

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Isoform specific function of calpain 2 in regulating membrane protrusion

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MEKK1 regulates calpain‐dependent proteolysis of focal adhesion proteins for rear‐end detachment of migrating fibroblasts

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Inhibition of Calpain Blocks Platelet Secretion, Aggregation, and Spreading

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Adhesion dynamics at a glance

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Calpain Mediates Integrin-induced Signaling at a Point Upstream of Rho Family Members

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Directional Persistence of EGF-Induced Cell Migration Is Associated with Stabilization of Lamellipodial Protrusions

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Calpain involvement in the remodeling of cytoskeletal anchorage complexes

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Integrin signaling cascades are operational in adult hippocampal synapses and modulate NMDA receptor physiology

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Calpain cleavage of integrin β cytoplasmic domains

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Myoblast migration is regulated by calpain through its involvement in cell attachment and cytoskeletal organization

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Proteolysis of Cortactin by Calpain Regulates Membrane Protrusion during Cell Migration

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Spatial Localization of m-Calpain to the Plasma Membrane by Phosphoinositide Biphosphate Binding during Epidermal Growth Factor Receptor-Mediated Activation

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Calpain-2 as a target for limiting prostate cancer invasion.

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Integrin αMβ2-Mediated Cell Migration to Fibrinogen and Its Recognition Peptides

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Protein Kinase Cι Promotes Nicotine-induced Migration and Invasion of Cancer Cells via Phosphorylation of μ- and m-Calpains

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Class- and Splice Variant-specific Association of CD98 with Integrin β Cytoplasmic Domains

Zent, R., Fenczik, C. A., Calderwood, D., Liu, S., Dellos, M., & Ginsberg, M. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.7.5059 · Cited by 110 · see citing works

Regulation of Cell Migration

Anna Huttenlocher, A., Palecek, S. P., Lauffenburger, D. A., Ginsberg, M. H., & Horwitz, A. F. (1997)

Regulating cell migration: calpains make the cut

Franco, S. J., & Anna Huttenlocher, A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02562 · Cited by 495 · see citing works

Molecules in focus

Perrin, B. J., & B, A. H. (2002)

Summary

Franco, S. J., & Anna Huttenlocher, A. (2005)

A calcium dependent de-adhesion mechanism regulates the direction and rate of cell migration: A mathematical model

Valeyev, N., Downing, A., Skorinkin, A., Campbell, I., & Kotov, N. (2006) · zvestiya of the National Academy of Sciences of Belarus (National Academy of Sciences of Belarus)