Weis, William I.

Crystal structure of the β2 adrenergic receptor–Gs protein complex

Rasmussen, S. G. F., DeVree, B. T., Zou, Y., Kruse, A. C., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., et al. (2011) · Nature

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 3,009

The Molecular Basis of G Protein–Coupled Receptor Activation

Weis, W. I., & Kobilka, B. K. (2018) · Annual Review of Biochemistry

Receptor Mechanisms and SignalingProtein Kinase Regulation and GTPase Signaling

Cited by 1,227

The -Catenin Destruction Complex

Stamos, J. L., & Weis, W. I. (2013) · Cold Spring Harbor Perspectives in Biology

Wnt/β-catenin signaling in development and cancerUbiquitin and proteasome pathways

Cited by 1,062

Architecture of the synaptotagmin–SNARE machinery for neuronal exocytosis

Zhou, Q., Lai, Y., Bacaj, T., Zhao, M., Lyubimov, A. Y., Uervirojnangkoorn, M., Zeldin, O. B., Brewster, A. S., Sauter, N. K., Cohen, A. E., et al. (2015) · Nature

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 348

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., et al. (2016) · Nature

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 330

Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist

Masureel, M., Zou, Y., Picard, L.-P., van der Westhuizen, E., Mahoney, J. P., Rodrigues, J. P. G. L. M., Mildorf, T. J., Dror, R. O., Shaw, D. E., Bouvier, M., et al. (2018) · Nature Chemical Biology

Receptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

Cited by 194

A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis

Fang, L., Zhu, Q., Neuenschwander, M., Specker, E., Wulf-Goldenberg, A., Weis, W. I., von Kries, J. P., & Birchmeier, W. (2016) · Cancer Research

Wnt/β-catenin signaling in development and cancerCancer Cells and Metastasis

Cited by 190

Goniometer-based femtosecond crystallography with X-ray free electron lasers

Cohen, A. E., Soltis, S. M., González, A., Aguila, L., Alonso-Mori, R., Barnes, C. O., Baxter, E. L., Brehmer, W., Brewster, A. S., Brunger, A. T., et al. (2014) · Proceedings of the National Academy of Sciences

Enzyme Structure and FunctionAdvanced X-ray Imaging Techniques

Cited by 144

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Bruguera, E. S., Mahoney, J. P., & Weis, W. I. (2025) · eLife

Wnt/β-catenin signaling in development and cancerCell Adhesion Molecules Research

Cited by 9

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Bruguera, E. S., Mahoney, J. P., & Weis, W. I. (2025) · eLife

Wnt/β-catenin signaling in development and cancerCell Adhesion Molecules Research

Cited by 2

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

Bruguera, E. S., Mahoney, J. P., & Weis, W. I. (2024) · eLife

Wnt/β-catenin signaling in development and cancerCell Adhesion Molecules Research

Cited by 2