Shen-Orr, Shai S.

Network motifs: simple building blocks of complex networks.

Milo, R., Shen-Orr, S., Itzkovitz, S., Kashtan, N., Chklovskii, D., & Alon, U. (2002) · Science

Complex Network Analysis TechniquesBioinformatics and Genomic Networks

Cited by 7,368

A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure

Baron, M., Veres, A., Wolock, S. L., Faust, A. L., Gaujoux, R., Vetere, A., Ryu, J. H., Wagner, B. K., Shen-Orr, S. S., Klein, A. M., et al. (2016) · Cell Systems

Single-cell and spatial transcriptomicsPancreatic function and diabetes

Cited by 1,508

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell

Genetic Associations and EpidemiologyImmune responses and vaccinations

Cited by 1,065

Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells

Moussaieff, A., Rouleau, M., Kitsberg, D., Cohen, M., Levy, G., Barasch, D., Nemirovski, A., Shen-Orr, S., Laevsky, I., Amit, M., et al. (2015) · Cell Metabolism

Pluripotent Stem Cells ResearchEpigenetics and DNA Methylation

Cited by 666

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

Sayed, N., Huang, Y., Nguyen, K., Krejciova-Rajaniemi, Z., Grawe, A. P., Gao, T., Tibshirani, R., Hastie, T., Alpert, A., Cui, L., et al. (2021) · Nature Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 572

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

Alpert, A., Pickman, Y., Leipold, M., Rosenberg-Hasson, Y., Ji, X., Gaujoux, R., Rabani, H., Starosvetsky, E., Kveler, K., Schaffert, S., et al. (2019) · Nature Medicine

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 513

Systems analysis of immunity to influenza vaccination across multiple years and in diverse populations reveals shared molecular signatures

Nakaya, H. I., Hagan, T., Duraisingham, S. S., Lee, E. K., Kwissa, M., Rouphael, N., Frasca, D., Gersten, M., Mehta, A. K., Gaujoux, R., et al. (2015) · Immunity

Influenza Virus Research StudiesImmune responses and vaccinations

Cited by 337

Cytomegalovirus infection enhances the immune response to influenza

Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., et al. (2015) · Science Translational Medicine

Cytomegalovirus and herpesvirus researchImmune responses and vaccinations

Cited by 332

Activation of the reward system boosts innate and adaptive immunity

Ben-Shaanan, T. L., Azulay-Debby, H., Dubovik, T., Starosvetsky, E., Korin, B., Schiller, M., Green, N. L., Admon, Y., Hakim, F., Shen-Orr, S. S., et al. (2016) · Nature Medicine

Vagus Nerve Stimulation ResearchStress Responses and Cortisol

Cited by 272

Defective signaling in the JAK-STAT pathway tracks with chronic inflammation and cardiovascular risk in aging humans

Shen-Orr, S. S., Furman, D., Kidd, B. A., Hadad, F., Lovelace, P., Huang, Y.-W., Rosenberg-Hasson, Y., Mackey, S., Grisar, F. A. G., Pickman, Y., et al. (2016) · Cell Systems

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 154

Alignment of single-cell trajectories to compare cellular expression dynamics

Alpert, A., Moore, L. S., Dubovik, T., & Shen-Orr, S. S. (2018) · Nature Methods

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 96

New tools for classification and monitoring of autoimmune diseases

Maecker, H. T., Lindstrom, T. M., Robinson, W. H., Utz, P. J., Hale, M., Boyd, S. D., Shen-Orr, S. S., & Fathman, C. G. (2012) · Nature Reviews Rheumatology

Rheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus Research

Cited by 95

Variability in the immune system: of vaccine responses and immune states

Shen-Orr, S. S., & Furman, D. (2013) · Current Opinion in Immunology

Immune responses and vaccinationsImmunotherapy and Immune Responses

Cited by 61