Cytomegalovirus infection enhances the immune response to influenza
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Cytomegalovirus infection of young adult humans and mice enhances immune responses to influenza.
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Cytokine stimulation assays have proven utility for assessing overall immune competence.
“Despite the proven utility of cytokine stimulation assays used in our study with respect to an individual’s overall immune competence5,24,25”
From An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging (2021) · cites this paper as [25]
Other studies found no relationship between CMV carrier status and reduced influenza vaccine responses with age; CMV infection even appeared to improve antibody responses in young individuals, possibly by activating innate cells.
“other studies have not found a relationship between CMV carrier status and reduced influenza vaccine responses with age; on the contrary, CMV infection appeared to even have a positive effect on antibody responses in young individuals, presumably by activating innate cells”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Furman et al., 2015
Immune changes associated with HCMV may have significant impact during co-infection and vaccination, as well as on general and immunological fitness.
“Immune changes associated with HCMV may have significant impact during co-infection and vaccination, as well as on general and immunological fitness.”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [55]
The correlation between HCMV positivity and impaired responses is controversial because this relationship is observed in some but not all studies.
“However, the correlation between HCMV positivity and impaired responses is controversial because this relationship is observed in some but not all studies (54–56).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [55]
Other studies have reported vaccine-boosting effects of CMV in young individuals.
“For example, some studies have shown no effect of CMV on vaccine responses in the elderly (den Elzen et al. 2011; O’Connor et al. 2014; Wald et al. 2013) and other studies have even reported vaccine-boosting effects of CMV in young individuals (Furman et al. 2015).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Furman et al. 2015
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- Authors
- Furman, D., Jojic, V., Sharma, S., Shen-Orr, S. S., L. Angel, C. J., Onengut-Gumuscu, S., Kidd, B. A., Maecker, H. T., Concannon, P., Dekker, C. L., Thomas, P. G., & Davis, M. M.
- Affiliations
- Stanford University (US)
- University of North Carolina at Chapel Hill (US)
- St. Jude Children's Research Hospital (US)
- Technion – Israel Institute of Technology (IL)
- Department of Microbiology and Immunology, School of Medicine, Stanford University, Stanford, CA 94305, USA.
- Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22903, USA.
- University of Virginia (US)
- Stanford Medicine (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Furman, David
- Jojic, Vladimir
- Sharma, Shalini
- Concannon, Patrick
- Davis, Mark M.
- ORCID
- Venue
- Science Translational Medicine
- Published
- 2015-04
- Volume
- 7
- Issue
- 281
- Pages
- 281ra43-281ra43
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC4505610
- OpenAlex
- W2098132870
- Cited by
- 332
- References
- 78
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 21 · 2023: 23 · 2022: 25 · 2021: 32 · 2020: 34 · 2019: 38 · 2018: 31 · 2017: 40 · 2016: 34 · 2015: 12
- FWCI
- 30.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- NIH (U19s AI057240, AI090019)
- Howard Hughes Medical Institute
- Howard Hughes Medical Institute Medical Research Fellow
- NIH/National Center for Research Resources Clinical and Translational Science Award (UL1 RR025744, R01AI107625)
- Ellison Medical Foundation (AG-SS-1788)
- Stanford Center on Longevity
- Israel Science Foundation (1365/12)
- NIH/NCRR CTSA (UL1 RR025744)
- DP3 (DK085678)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Keywords
- cytomegalovirus, viral latency, influenza vaccination, antibody response, CD8+ T cells, interferon-gamma, immunosenescence, seropositivity, murine cytomegalovirus, cross-protection, cytokines and chemokines, immunophenotyping, gene expression
- MeSH terms
- Adult, Aged, Aged, 80 and over, Aging, Animals, Cytomegalovirus Infections, Cytomegalovirus, Female, Humans, Immunity, Influenza, Human, Interferon-gamma, Mice, Inbred C57BL, Middle Aged, Time Factors, Vaccination, CD4-Positive T-Lymphocytes, CD28 Antigens, Muromegalovirus, Mice, Knockout, CD8-Positive T-Lymphocytes, Viral Load, Polymorphism, Single Nucleotide, Young Adult, Cross Protection
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