Sorger, Peter K.

Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.

Schauer, N. J., Liu, X., Magin, R. S., Doherty, L. M., Chan, W. C., Ficarro, S. B., Hu, W., Roberts, R. M., Iacob, R. E., Stolte, B., et al. (2020) · Scientific Reports

Ubiquitin and proteasome pathwaysCancer-related Molecular Pathways

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GRcalculator: an online tool for calculating and mining dose–response data

Clark, N. A., Hafner, M., Kouril, M., Williams, E. H., Muhlich, J. L., Pilarczyk, M., Niepel, M., Sorger, P. K., & Medvedovic, M. (2017) · BMC Cancer

Computational Drug Discovery MethodsCell Image Analysis Techniques

Cited by 121

Analysis of kinesin motor function at budding yeast kinetochores

Tytell, J. D., & Sorger, P. K. (2006) · The Journal of Cell Biology

Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics

Cited by 116

Biophysical prediction of protein–peptide interactions and signaling networks using machine learning

Cunningham, J. M., Rogers, J. R., Koytiger, G., Sorger, P. K., & AlQuraishi, M. (2020) · Nature Methods

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 108

Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c‐Jun pathway in adaptive resistance to drug‐induced apoptosis

Fallahi‐Sichani, M., Moerke, N. J., Niepel, M., Zhang, T., Gray, N. S., & Sorger, P. K. (2015) · Molecular Systems Biology

Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase Signaling

Cited by 99

Differentiable biology: using deep learning for biophysics-based and data-driven modeling of molecular mechanisms

AlQuraishi, M., & Sorger, P. K. (2021) · Nature Methods

Machine Learning in BioinformaticsGene Regulatory Network Analysis

Cited by 96

Properties of cell death models calibrated and compared using Bayesian approaches

Eydgahi, H., Chen, W. W., Muhlich, J. L., Vitkup, D., Tsitsiklis, J. N., & Sorger, P. K. (2013) · Molecular Systems Biology

Gene Regulatory Network AnalysisCell death mechanisms and regulation

Cited by 84

Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis

Kallenberger, S. M., Beaudouin, J., Claus, J., Fischer, C., Sorger, P. K., Legewie, S., & Eils, R. (2014) · Science Signaling

Cell death mechanisms and regulationGene Regulatory Network Analysis

Cited by 76

Protein structure prediction by AlphaFold 2: are attention and symmetries all you need?

Bouatta, N., Sorger, P., & AlQuraishi, M. (2021) · Acta Crystallographica Section D Structural Biology

Protein Structure and DynamicsMachine Learning in Bioinformatics

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Structure-Based Design of a Potent and Selective Covalent Inhibitor for SRC Kinase That Targets a P-Loop Cysteine

Du, G., Rao, S., Gurbani, D., Henning, N. J., Jiang, J., Che, J., Yang, A., Ficarro, S. B., Marto, J. A., Aguirre, A. J., et al. (2020) · Journal of Medicinal Chemistry

Heterocyclic Compound Synthesis and BioactivityProtein Kinase Regulation and GTPase Signaling

Cited by 39

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma

Rendo, V., Lee, E. Q., Bossi, C., Khuu, N., Rudek, M. A., Pal, S., Azazmeh, N., Rashid, R., Lin, J.-R., Cusick, M., et al. (2025) · Science Translational Medicine

Glioma Diagnosis and TreatmentCancer-related Molecular Pathways

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