Intra- and Interdimeric Caspase-8 Self-Cleavage Controls Strength and Timing of CD95-Induced Apoptosis
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Dual modes of activation of caspase-8 enable precise control of apoptosis.
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Binding of CASP8 to FADD enables assembly of a linear filament of CASP8 molecules that facilitates homodimerization and activation by autoproteolytic cleavage.
“This interaction enables the assembly of a linear filament of CASP8 molecules (depending on their DEDs) that facilitates homodimerization and consequent activation by autoproteolytic cleavage [291–295].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [295]
CASP8 maturation involves a cascade initiated by binding of CASP8 to FADD at DISC.
“In particular, CASP8 maturation involves a cascade of events initiated by the binding of CASP8 to FADD at the DISC.”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [295]
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- Authors
- Kallenberger, S. M., Beaudouin, J., Claus, J., Fischer, C., Sorger, P. K., Legewie, S., & Eils, R.
- Affiliations
- German Cancer Research Center (DE)
- Apogenix (Germany) (DE)
- Harvard University (US)
- Institute of Molecular Biology (DE)
- Corresponding author
- Legewie, Stefan
- Eils, Roland
- Venue
- Science Signaling
- Published
- 2014-03-11
- Volume
- 7
- Issue
- 316
- Pages
- ra23-ra23
- ISSN
- 1937-9145 (ISSN-L)
- 1945-0877
- PMC
- PMC4208692
- OpenAlex
- W2116755620
- Cited by
- 76
- References
- 61
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 11 · 2014: 3
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Signaling (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5p50gm068762-10)
- National Institute of General Medical Sciences (GM 68762, P50-GM068762)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- caspase-8, Fas ligand, apoptosis, death-inducing signaling complex, single-cell imaging, multiscale modeling
- MeSH terms
- Computer Simulation, Cytosol, Flow Cytometry, HeLa Cells, Humans, Image Processing, Computer-Assisted, Models, Biological, Blotting, Western, Signal Transduction, Apoptosis, Dimerization, Caspase 8, Fas Ligand Protein, Death Domain Receptor Signaling Adaptor Proteins, Single-Cell Analysis
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