Sorger, Peter K.

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science

Single-cell and spatial transcriptomicsCancer Immunotherapy and Biomarkers

Cited by 4,944

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

Jerby-Arnon, L., Shah, P., Cuoco, M. S., Rodman, C., Su, M.-J., Melms, J. C., Leeson, R., Kanodia, A., Mei, S., Lin, J.-R., et al. (2018) · Cell

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 1,429

Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation

Sorger, P. K., & Pelham, H. R. B. (1988) · Cell

Heat shock proteins researchFungal and yeast genetics research

Cited by 832

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

Chandrashekar, A., Liu, J., Martinot, A. J., McMahan, K., Mercado, N. B., Peter, L., Tostanoski, L. H., Yu, J., Maliga, Z., Nekorchuk, M., et al. (2020) · Science

SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studies

Cited by 816

Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

Ringel, A. E., Drijvers, J. M., Baker, G. J., Catozzi, A., García-Cañaveras, J. C., Gassaway, B. M., Miller, B. C., Juneja, V. R., Nguyen, T. H., Joshi, S., et al. (2020) · Cell

Cancer Immunotherapy and BiomarkersImmune cells in cancer

Cited by 780

Growth rate inhibition metrics correct for confounders in measuring sensitivity to cancer drugs

Hafner, M., Niepel, M., Chung, M., & Sorger, P. K. (2016) · Nature Methods

Cancer Cells and MetastasisComputational Drug Discovery Methods

Cited by 681

Combination Cancer Therapy Can Confer Benefit via Patient-to-Patient Variability without Drug Additivity or Synergy

Palmer, A. C., & Sorger, P. K. (2017) · Cell

Cancer Cells and MetastasisMathematical Biology Tumor Growth

Cited by 642

Heat shock factor and the heat shock response

Sorger, P. K. (1991) · Cell

Heat shock proteins researchGenomics and Chromatin Dynamics

Cited by 603

Physicochemical modelling of cell signalling pathways

Aldridge, B. B., Burke, J. M., Lauffenburger, D. A., & Sorger, P. K. (2006) · Nature Cell Biology

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 592

Systems biology and combination therapy in the quest for clinical efficacy

Fitzgerald, J. B., Schoeberl, B., Nielsen, U. B., & Sorger, P. K. (2006) · Nature Chemical Biology

Computational Drug Discovery MethodsGene Regulatory Network Analysis

Cited by 570

Single-sequence protein structure prediction using language models from deep learning

Chowdhury, R., Bouatta, N., Biswas, S., Rochereau, C., Church, G. M., Sorger, P. K., & AlQuraishi, M. (2021) · Nature Biotechnology

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 455

Single-sequence protein structure prediction using a language model and deep learning

Chowdhury, R., Bouatta, N., Biswas, S., Floristean, C., Kharkar, A., Roy, K., Rochereau, C., Ahdritz, G., Zhang, J., Church, G. M., et al. (2022) · Nature Biotechnology

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 455

Towards a rigorous assessment of systems biology models: the DREAM3 challenges

Prill, R. J., Marbach, D., Saez-Rodriguez, J., Sorger, P. K., Alexopoulos, L. G., Xue, X., Clarke, N. D., Altan-Bonnet, G., & Stolovitzky, G. (2010) · PLoS ONE

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 439

OpenFold: retraining AlphaFold2 yields new insights into its learning mechanisms and capacity for generalization

Ahdritz, G., Bouatta, N., Floristean, C., Kadyan, S., Xia, Q., Gerecke, W., O’Donnell, T. J., Berenberg, D., Fisk, I., Zanichelli, N., et al. (2024) · Nature Methods

Protein Structure and DynamicsMachine Learning in Bioinformatics

Cited by 439

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations

Keenan, A. B., Jenkins, S. L., Jagodnik, K. M., Koplev, S., He, E., Torre, D., Wang, Z., Dohlman, A. B., Silverstein, M. C., Lachmann, A., et al. (2018) · Cell Systems

Bioinformatics and Genomic NetworksGene Regulatory Network Analysis

Cited by 423

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Chen, W. W., Schoeberl, B., Jasper, P. J., Niepel, M., Nielsen, U. B., Lauffenburger, D. A., & Sorger, P. K. (2009) · Molecular Systems Biology

HER2/EGFR in Cancer ResearchGene Regulatory Network Analysis

Cited by 391

Machine learning identifies candidates for drug repurposing in Alzheimer’s disease

Rodriguez, S., Hug, C., Todorov, P., Moret, N., Boswell, S. A., Evans, K., Zhou, G., Johnson, N. T., Hyman, B. T., Sorger, P. K., et al. (2021) · Nature Communications

Computational Drug Discovery MethodsAlzheimer's disease research and treatments

Cited by 299

Multiomics Profiling Establishes the Polypharmacology of FDA-Approved CDK4/6 Inhibitors and the Potential for Differential Clinical Activity

Hafner, M., Mills, C. E., Subramanian, K., Chen, C., Chung, M., Boswell, S. A., Everley, R. A., Liu, C., Walmsley, C. S., Juric, D., et al. (2019) · Cell Chemical Biology

Advanced Breast Cancer TherapiesPI3K/AKT/mTOR signaling in cancer

Cited by 250

Vascular Disease and Thrombosis in SARS-CoV-2-Infected Rhesus Macaques

Aid, M., Busman-Sahay, K., Vidal, S. J., Maliga, Z., Bondoc, S., Starke, C., Terry, M., Jacobson, C. A., Wrijil, L., Ducat, S., et al. (2020) · Cell

COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 Research

Cited by 215

Cyclic Immunofluorescence (CycIF), A Highly Multiplexed Method for Single‐cell Imaging

Lin, J., Fallahi‐Sichani, M., Chen, J., & Sorger, P. K. (2016) · Current Protocols in Chemical Biology

Advanced Fluorescence Microscopy TechniquesCell Image Analysis Techniques

Cited by 208

Targeting TBK1 to overcome resistance to cancer immunotherapy

Sun, Y., Revach, O.-Y., Anderson, S., Kessler, E. A., Wolfe, C. H., Jenney, A., Mills, C. E., Robitschek, E. J., Davis, T. G. R., Kim, S., et al. (2023) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 174

Discovery and resistance mechanism of a selective CDK12 degrader

Jiang, B., Gao, Y., Che, J., Lu, W., Kaltheuner, I. H., Dries, R., Kalocsay, M., Berberich, M. J., Jiang, J., You, I., et al. (2021) · Nature Chemical Biology

Protein Degradation and InhibitorsHistone Deacetylase Inhibitors Research

Cited by 150

Surviving apoptosis: life–death signaling in single cells

Flusberg, D. A., & Sorger, P. K. (2015) · Trends in Cell Biology

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 149

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines

Niepel, M., Hafner, M., Mills, C. E., Subramanian, K., Williams, E. H., Chung, M., Gaudio, B., Barrette, A. M., Stern, A. D., Hu, B., et al. (2019) · Cell Systems

Scientific Computing and Data ManagementAnimal testing and alternatives

Cited by 133