Ashcroft, Frances M.

Properties of single potassium channels modulated by glucose in rat pancreatic beta‐cells.

Ashcroft, F. M., Ashcroft, S. J., & Harrison, D. E. (1988) · The Journal of Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 135

Mechanism of Cloned ATP-sensitive Potassium Channel Activation by Oleoyl-CoA

Gribble, F. M., Proks, P., Corkey, B. E., & Ashcroft, F. M. (1998) · Journal of Biological Chemistry

Ion channel regulation and functionPancreatic function and diabetes

Cited by 133

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Brereton, M. F., Rohm, M., Shimomura, K., Holland, C., Tornovsky-Babeay, S., Dadon, D., Iberl, M., Chibalina, M. V., Lee, S., Glaser, B., et al. (2016) · Nature Communications

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 124

New insights into KATP channel gene mutations and neonatal diabetes mellitus

Pipatpolkai, T., Usher, S., Stansfeld, P. J., & Ashcroft, F. M. (2020) · Nature Reviews Endocrinology

Pancreatic function and diabetesIon channel regulation and function

Cited by 122

R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion

Zhang, Q., Bengtsson, M., Partridge, C., Salehi, A., Braun, M., Cox, R., Eliasson, L., Johnson, P. R., Renström, E., Schneider, T., et al. (2007) · Nature Cell Biology

Pancreatic function and diabetesIon channel regulation and function

Cited by 110

ATP-sensitive K + channels and disease: from molecule to malady

Ashcroft, F. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism

Pancreatic function and diabetesIon channel regulation and function

Cited by 107

Neonatal Diabetes and the K ATP Channel: From Mutation to Therapy

Ashcroft, F. M., Puljung, M. C., & Vedovato, N. (2017) · Trends in Endocrinology & Metabolism

Pancreatic function and diabetesIon channel regulation and function

Cited by 106

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

Girard, C. A., Wunderlich, F. T., Shimomura, K., Collins, S., Kaizik, S., Proks, P., Abdulkader, F., Clark, A., Ball, V., Zubcevic, L., et al. (2008) · Journal of Clinical Investigation

Pancreatic function and diabetesIon channel regulation and function

Cited by 105

Na+ current properties in islet α‐ and β‐cells reflect cell‐specific Scn3a and Scn9a expression

Zhang, Q., Chibalina, M. V., Bengtsson, M., Groschner, L. N., Ramracheya, R., Rorsman, N. J. G., Leiss, V., Nassar, M. A., Welling, A., Gribble, F. M., et al. (2014) · The Journal of Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 90

Successful transfer to sulfonylureas in KCNJ11 neonatal diabetes is determined by the mutation and duration of diabetes

Babiker, T., Vedovato, N., Patel, K., Thomas, N., Finn, R., Männikkö, R., Chakera, A. J., Flanagan, S. E., Shepherd, M. H., Ellard, S., et al. (2016) · Diabetologia

Pancreatic function and diabetesIon channel regulation and function

Cited by 90

Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane

Olofsson, C. S., Collins, S., Bengtsson, M., Eliasson, L., Salehi, A., Shimomura, K., Tarasov, A., Holm, C., Ashcroft, F., & Rorsman, P. (2007) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 87

Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

Ashcroft, F. M., Rohm, M., Clark, A., & Brereton, M. F. (2017) · Cell Metabolism

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 84

A fluorimetric and amperometric study of calcium and secretion in isolated mouse pancreatic ?-cells

Smith, P. A., Duchen, M. R., & Ashcroft, F. M. (1995) · Pfl�gers Archiv European Journal of Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 80

ATP Sensitivity of the ATP-Sensitive K+ Channel in Intact and Permeabilized Pancreatic β-Cells

Tarasov, A. I., Girard, C. A. J., & Ashcroft, F. M. (2006) · Diabetes

Ion channel regulation and functionPancreatic function and diabetes

Cited by 68

How ATP Inhibits the Open KATP Channel

Craig, T. J., Ashcroft, F. M., & Proks, P. (2008) · The Journal of General Physiology

Ion channel regulation and functionATP Synthase and ATPases Research

Cited by 67

Functional identification of islet cell types by electrophysiological fingerprinting

Briant, L. J. B., Zhang, Q., Vergari, E., Kellard, J. A., Rodriguez, B., Ashcroft, F. M., & Rorsman, P. (2017) · Journal of The Royal Society Interface

Pancreatic function and diabetesNeural dynamics and brain function

Cited by 59

Separate processes mediate nucleotide-induced inhibition and stimulation of the ATP-regulated K + -channels in mouse pancreatic β-cells

Bokvist, K. B., Ämmälä, C., Ashcroft, F. M., Berggren, P., Larsson, O., & Rorsman, P. (1991) · Proceedings of the Royal Society of London. Series B: Biological Sciences

Ion channel regulation and functionPancreatic function and diabetes

Cited by 54

Activation of the KATP channel by Mg-nucleotide interaction with SUR1

Proks, P., de Wet, H., & Ashcroft, F. M. (2010) · Journal of General Physiology

Ion channel regulation and functionAdenosine and Purinergic Signaling

Cited by 51

The ATP- and tolbutamide-sensitivity of the ATP-sensitive K-channel from human pancreatic B cells

Ashcroft, F. M., Kakei, M., Gibson, J. S., Gray, D. W., & Sutton, R. (1989) · Diabetologia

Ion channel regulation and functionPancreatic function and diabetes

Cited by 39

Loss of electrical β-cell to δ-cell coupling underlies impaired hypoglycaemia-induced glucagon secretion in type-1 diabetes

Hill, T. G., Gao, R., Benrick, A., Kothegala, L., Rorsman, N., Santos, C., Acreman, S., Briant, L. J., Dou, H., Gandasi, N. R., et al. (2024) · Nature Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 37

Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: A mechanistic study

Proks, P., de Wet, H., & Ashcroft, F. M. (2014) · Journal of General Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 22

Running out of time: the decline of channel activity and nucleotide activation in adenosine triphosphate-sensitive K-channels

Proks, P., Puljung, M. C., Vedovato, N., Sachse, G., Mulvaney, R., & Ashcroft, F. M. (2016) · Philosophical Transactions of the Royal Society B: Biological Sciences

Ion channel regulation and functionAdenosine and Purinergic Signaling

Cited by 11