Freeman, Alexandra F.

Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

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Expansion of the Human Phenotype Ontology (HPO) knowledge base and resources

Köhler, S., Carmody, L., Vasilevsky, N., Jacobsen, J. O. B., Danis, D., Gourdine, J.-P., Gargano, M., Harris, N. L., Matentzoglu, N., McMurry, J. A., et al. (2019) · Nucleic Acids Research

Biomedical Text Mining and OntologiesGenomics and Rare Diseases

Cited by 677

Cold Urticaria, Immunodeficiency, and Autoimmunity Related to PLCG2 Deletions

Ombrello, M. J., Remmers, E. F., Sun, G., Freeman, A. F., Datta, S., Torabi-Parizi, P., Subramanian, N., Bunney, T. D., Baxendale, R. W., Martins, M. S., et al. (2012) · New England Journal of Medicine

Immunodeficiency and Autoimmune DisordersInflammasome and immune disorders

Cited by 425

A dysbiotic microbiome triggers T H 17 cells to mediate oral mucosal immunopathology in mice and humans

Dutzan, N., Kajikawa, T., Abusleme, L., Greenwell-Wild, T., Zuazo, C. E., Ikeuchi, T., Brenchley, L., Abe, T., Hurabielle, C., Martin, D., et al. (2018) · Science Translational Medicine

Oral microbiology and periodontitis researchPsoriasis: Treatment and Pathogenesis

Cited by 382

Extrapulmonary Aspergillus infection in patients with CARD9 deficiency

Rieber, N., Gazendam, R. P., Freeman, A. F., Hsu, A. P., Collar, A. L., Sugui, J. A., Drummond, R. A., Rongkavilit, C., Hoffman, K., Henderson, C., et al. (2016) · JCI Insight

Immunodeficiency and Autoimmune DisordersAntifungal resistance and susceptibility

Cited by 171

An update on the hyper-IgE syndromes

Yong, P. F., Freeman, A. F., Engelhardt, K. R., Holland, S., Puck, J. M., & Grimbacher, B. (2012) · Arthritis Research & Therapy

Immunodeficiency and Autoimmune DisordersBlood disorders and treatments

Cited by 154

Diminished allergic disease in patients with STAT3 mutations reveals a role for STAT3 signaling in mast cell degranulation

Siegel, A. M., Stone, K. D., Cruse, G., Lawrence, M. G., Olivera, A., Jung, M.-Y., Barber, J. S., Freeman, A. F., Holland, S. M., O'Brien, M., et al. (2013) · Journal of Allergy and Clinical Immunology

Immunodeficiency and Autoimmune DisordersMast cells and histamine

Cited by 131

Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation

Bhanushali, M. J., Kranick, S. M., Freeman, A. F., Cuellar-Rodriguez, J. M., Battiwalla, M., Gea-Banacloche, J. C., Hickstein, D. D., Pavletic, S., Fahle, G., & Nath, A. (2013) · Neurology

Cytomegalovirus and herpesvirus researchViral-associated cancers and disorders

Cited by 97

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis

Hox, V., O'Connell, M. P., Lyons, J. J., Sackstein, P., Dimaggio, T., Jones, N., Nelson, C., Boehm, M., Holland, S. M., Freeman, A. F., et al. (2016) · Journal of Allergy and Clinical Immunology

Mast cells and histamineImmunodeficiency and Autoimmune Disorders

Cited by 64

Hematopoietic stem cell transplant effectively rescues lymphocyte differentiation and function in DOCK8-deficient patients

Pillay, B. A., Avery, D. T., Smart, J. M., Cole, T., Choo, S., Chan, D., Gray, P. E., Frith, K., Mitchell, R., Phan, T. G., et al. (2019) · JCI Insight

Immunodeficiency and Autoimmune DisordersHematopoietic Stem Cell Transplantation

Cited by 43

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome

Bocchini, C. E., Nahmod, K., Katsonis, P., Kim, S., Kasembeli, M. M., Freeman, A., Lichtarge, O., Makedonas, G., & Tweardy, D. J. (2016) · Blood

Immunodeficiency and Autoimmune DisordersCytokine Signaling Pathways and Interactions

Cited by 36

Migration-induced cell shattering due to DOCK8 deficiency causes a type 2–biased helper T cell response

Schneider, C., Shen, C., Gopal, A. A., Douglas, T., Forestell, B., Kauffman, K. D., Rogers, D., Artusa, P., Zhang, Q., Jing, H., et al. (2020) · Nature Immunology

Immunodeficiency and Autoimmune DisordersT-cell and B-cell Immunology

Cited by 31

HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions

Cook, S., Lenardo, M. J., & Freeman, A. F. (2022) · Journal of Clinical Immunology

Immunodeficiency and Autoimmune DisordersBlood disorders and treatments

Cited by 24