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Angiotensin II- and Salt-Induced Kidney Injury through Rac1-Mediated Mineralocorticoid Receptor Activation

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Androgen-Induced Cell Migration: Role of Androgen Receptor/Filamin A Association

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Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?

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A Cell Active Chemical GEF Inhibitor Selectively Targets the Trio/RhoG/Rac1 Signaling Pathway

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Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors

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Induction of Nonapoptotic Cell Death by Activated Ras Requires Inverse Regulation of Rac1 and Arf6

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The role of Rac1 in the regulation of NF-kB activity, cell proliferation, and cell migration in non-small cell lung carcinoma

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Rho GTPases in hepatocellular carcinoma

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Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinoma

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Critical off‐target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets

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Vascular Smooth Muscle LRP6 Limits Arteriosclerotic Calcification in Diabetic LDLR −/− Mice by Restraining Noncanonical Wnt Signals

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Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

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Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia

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The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model

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The F-BAR domain protein PACSIN2 associates with Rac1 and regulates cell spreading and migration

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Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac

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A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition

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An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis

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Drugging the Small GTPase Pathways in Cancer Treatment: Promises and Challenges

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The Small GTPase Rac1 Increases Cell Surface Stiffness and Enhances 3D Migration Into Extracellular Matrices

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Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS

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The small GTPase Rac1 is a novel binding partner of Bcl-2 and stabilizes its antiapoptotic activity

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Adherens junction regulates cryptic lamellipodia formation for epithelial cell migration

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Preclinical Development of Novel Rac1-GEF Signaling Inhibitors using a Rational Design Approach in Highly Aggressive Breast Cancer Cell Lines

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Macropinocytosis drives T cell growth by sustaining the activation of mTORC1

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Rap1-Rac1 Circuits Potentiate Platelet Activation

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Blockade of Inflammatory Responses by a Small-Molecule Inhibitor of the Rac Activator DOCK2

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Function of the Nucleotide Exchange Activity of Vav1 in T Cell Development and Activation

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Rac‐GTPase promotes fibrotic TGF‐β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways

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Direct Modulation of Small GTPase Activity and Function

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Modulation of actin dynamics by Rac1 to target cognitive function

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Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes

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Receptor-specific regulation of ERK1/2 activation by members of the “free fatty acid receptor” family

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The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy

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Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus

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The small GTPase RhoG mediates glioblastoma cell invasion

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Attacking the supply wagons to starve cancer cells to death

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mTOR Signalling in Head and Neck Cancer: Heads Up

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RAC1B: A Rho GTPase with Versatile Functions in Malignant Transformation and Tumor Progression

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GIT1 and βPIX Are Essential for GABAA Receptor Synaptic Stability and Inhibitory Neurotransmission

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Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer

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Death pathways triggered by activated Ras in cancer cells

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Identification of a Small GTPase Inhibitor Using a High-Throughput Flow Cytometry Bead-Based Multiplex Assay

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Loss of the E3 ubiquitin ligase HACE1 results in enhanced Rac1 signaling contributing to breast cancer progression

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RAC1 as a Therapeutic Target in Malignant Melanoma

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Targeting the cytoskeleton against metastatic dissemination

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Targeting of Rac GTPases blocks the spread of intact human breast cancer

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Rnd3/RhoE Is down-regulated in hepatocellular carcinoma and controls cellular invasion

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The physiological regulation of macropinocytosis during Dictyostelium growth and development

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Inhibition of the Rho GTPase, Rac1, decreases estrogen receptor levels and is a novel therapeutic strategy in breast cancer

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Essential role of endocytosis for Interleukin-4 receptor mediated JAK/STAT signalling

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Targeting Rho GTPase Signaling for Cancer Therapy

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Unraveling a novel Rac1-mediated signaling pathway that regulates cofilin dephosphorylation and secretion in thrombin-stimulated platelets

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Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma

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A Potent and Selective Inhibitor of Cdc42 GTPase

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G protein signaling in the parasite Entamoeba histolytica

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The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment

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RHO GTPase family in hepatocellular carcinoma

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An Integrated Imaging Approach to the Study of Oxidative Stress Generation by Mitochondrial Dysfunction in Living Cells

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The role of Rac in tumor susceptibility and disease progression: from biochemistry to the clinic

Casado‐Medrano, V., Baker, M. J., López‐Haber, C., Cooke, M., Wang, S., Caloca, M. J., & Kazanietz, M. G. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170519 · Cited by 55 · see citing works

Regulation of Epithelial-Mesenchymal Transition in Breast Cancer Cells by Cell Contact and Adhesion

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Low-intensity pulsed ultrasound promotes cell motility through vinculin-controlled Rac1 GTPase activity

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Tiam1/Rac1 complex controls Il17a transcription and autoimmunity

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Allometrically scaling tissue forces drive pathological foreign-body responses to implants via Rac2-activated myeloid cells

Padmanabhan, J., Chen, K., Sivaraj, D., Henn, D., Kuehlmann, B. A., Kussie, H. C., Zhao, E. T., Kahn, A., Bonham, C. A., Dohi, T., et al. (2023) · Nature Biomedical Engineering · doi:10.1038/s41551-023-01091-5 · Cited by 57 · see citing works

The Phospholipase Cγ2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein

Walliser, C., Hermkes, E., Schade, A., Wiese, S., Deinzer, J., Zapatka, M., Désiré, L., Mertens, D., Stilgenbauer, S., & Gierschik, P. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.746842 · Cited by 51 · see citing works

Development of EHop-016

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Activation of endothelial ras-related C3 botulinum toxin substrate 1 (Rac1) improves post-stroke recovery and angiogenesis via activating Pak1 in mice

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Relevance of small GTPase Rac1 pathway in drug and radio-resistance mechanisms: Opportunities in cancer therapeutics

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RAC1b Overexpression Confers Resistance to Chemotherapy Treatment in Colorectal Cancer

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Cross-talk between androgen receptor/filamin A and TrkA regulates neurite outgrowth in PC12 cells

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Role of non-genomic androgen signalling in suppressing proliferation of fibroblasts and fibrosarcoma cells

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High-Throughput Screening for Small-Molecule Inhibitors of LARG-Stimulated RhoA Nucleotide Binding via a Novel Fluorescence Polarization Assay

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Characterization of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases

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Characterization of EHop-016, Novel Small Molecule Inhibitor of Rac GTPase

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Characterization of EHop‐016, a novel small molecule inhibitor of Rac GTPase

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Rational design and characterization of a Rac GTPase-specific small molecule inhibitor

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Abstract P5-03-01: Therapeutic targeting of Rac GTPases in ER+ and HER2+ breast cancer

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