Díaz, J. Fernando

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures

Kellogg, E. H., Hejab, N. M. A., Howes, S., Northcote, P., Miller, J. H., Díaz, J. F., Downing, K. H., & Nogales, E. (2017) · Journal of Molecular Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 234

Microtubule Interactions with Chemically Diverse Stabilizing Agents: Thermodynamics of Binding to the Paclitaxel Site Predicts Cytotoxicity

Buey, R. M., Barasoain, I., Jackson, E., Meyer, A., Giannakakou, P., Paterson, I., Mooberry, S., Andreu, J. M., & Díaz, J. F. (2005) · Chemistry & Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 231

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites

Buey, R. M., Calvo, E., Barasoain, I., Pineda, O., Edler, M. C., Matesanz, R., Cerezo, G., Vanderwal, C. D., Day, B. W., Sorensen, E. J., et al. (2007) · Nature Chemical Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 156

Structural insight into the stabilization of microtubules by taxanes

Prota, A. E., Lucena-Agell, D., Ma, Y., Estevez-Gallego, J., Li, S., Bargsten, K., Josa-Prado, F., Altmann, K.-H., Gaillard, N., Kamimura, S., et al. (2023) · eLife

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 78

Structural model for differential cap maturation at growing microtubule ends

Estévez-Gallego, J., Josa-Prado, F., Ku, S., Buey, R. M., Balaguer, F. A., Prota, A. E., Lucena-Agell, D., Kamma-Lorger, C., Yagi, T., Iwamoto, H., et al. (2020) · eLife

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 65

Lattice defects induced by microtubule-stabilizing agents exert a long-range effect on microtubule growth by promoting catastrophes

Rai, A., Liu, T., Katrukha, E. A., Estévez-Gallego, J., Manka, S. W., Paterson, I., Díaz, J. F., Kapitein, L. C., Moores, C. A., & Akhmanova, A. (2021) · Proceedings of the National Academy of Sciences

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

Cited by 38

Taxane-induced conformational changes in the microtubule lattice activate GEF-H1-dependent RhoA signalling

Meiring, J. C. M., Mahapatra, V., Liu, R., Gravett, M. S. C., Morren, D., Saunders, H. A. J., Choi, S. R., Pelster José, A., Karhanova, A., Metallidou, I., et al. (2026) · Nature Cell Biology

Microtubule and mitosis dynamicsCancer Treatment and Pharmacology

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