Microtubule Interactions with Chemically Diverse Stabilizing Agents: Thermodynamics of Binding to the Paclitaxel Site Predicts Cytotoxicity

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works

Microtubules as a target for anticancer drugs

Jordan, M. A., & Wilson, L. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1317 · Cited by 4,534 · see citing works

Promotion of microtubule assembly in vitro by taxol

SCHIFF, P. B., FANT, J., & HORWITZ, S. B. (1979) · Nature · doi:10.1038/277665a0 · Cited by 3,600 · see citing works

Taxol stabilizes microtubules in mouse fibroblast cells.

Schiff, P. B., & Horwitz, S. B. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.3.1561 · Cited by 1,971 · see citing works

Structure and Mechanism in Protein Science

Fersht, A. (1998) · Cited by 1,890 · see citing works

Structure and mechanism

Oppenheimer, N. J., & James, T. L. (1989) · Academic Press eBooks · Cited by 820 · see citing works

Mechanism of Action of Antitumor Drugs that Interact with Microtubules and Tubulin

Jordan, M. A. (2005) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011023354290 · Cited by 776 · see citing works

From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance

Litman, T., Druley, T. E., Stein, W. D., & Bates, S. E. (2001) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000912 · Cited by 687 · see citing works

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action.

Bollag, D. M., McQueney, P. A., Zhu, J., Hensens, O. D., Koupal, L. R., Liesch, J. M., Goetz, M., Lazarides, E., & Woods, C. M. (1995) · PubMed · Cited by 687 · see citing works

Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization

Giannakakou, P., Sackett, D. L., Kang, Y., Zhan, Z., Buters, J., Fojo, T., & Poruchynsky, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17118 · Cited by 682 · see citing works

Thermodynamics of the Polymerization of Protein

JOHNSON, P. (1976) · Biochemical Society Transactions · doi:10.1042/bst0041168 · Cited by 584 · see citing works

Thermodynamics of the polymerization of protein

Oosawa, F., & Asakura, S. (1975) · Cited by 580 · see citing works

P-glycoprotein and multidrug resistance

Gottesman, M. M., PASTAN, I., & Ambudkar, S. V. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80091-8 · Cited by 564 · see citing works

THE MECHANISM OF COLCHICINE INHIBITION OF MITOSIS

Taylor, E. W. (1965) · The Journal of Cell Biology · doi:10.1083/jcb.25.1.145 · Cited by 424 · see citing works

Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: Reversibility, ligand stoichiometry, and competition

Díaz, J. F., & Andreu, J. M. (1993) · Biochemistry · doi:10.1021/bi00062a003 · Cited by 413 · see citing works

Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells.

Bhalla, K. N., Ibrado, A. M., Tourkina, E., Tang, C., Mahoney, M. E., & Huang, Y. (1993) · PubMed · Cited by 273 · see citing works

The Microtubule-Stabilizing Agent Discodermolide Competitively Inhibits the Binding of Paclitaxel (Taxol) to Tubulin Polymers, Enhances Tubulin Nucleation Reactions More Potently than Paclitaxel, and Inhibits the Growth of Paclitaxel-Resistant Cells

Kowalski, R. J., Giannakakou, P., Gunasekera, S. P., Longley, R. E., Day, B. W., & Hamel, E. (1997) · Molecular Pharmacology · doi:10.1124/mol.52.4.613 · Cited by 262 · see citing works

The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity

Pryor, D. E., O’Brate, A., Bilcer, G. M., Díaz, J. F., Wang, Y., Wang, Y., Kabaki, M., Jung, M. K., Andreu, J. M., Ghosh, A. K., et al. (2002) · Biochemistry · doi:10.1021/bi020211b · Cited by 258 · see citing works

Peloruside A Does Not Bind to the Taxoid Site on β-Tubulin and Retains Its Activity in Multidrug-Resistant Cell Lines

Gaitanos, T. N., Buey, R. M., Díaz, J. F., Northcote, P. T., Teesdale‐Spittle, P. H., Andreu, J. M., & Miller, J. H. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0771 · Cited by 193 · see citing works

The Coral-Derived Natural Products Eleutherobin and Sarcodictyins A and B: Effects on the Assembly of Purified Tubulin with and without Microtubule-Associated Proteins and Binding at the Polymer Taxoid Site

Hamel, E., Sackett, D. L., Vourloumis, D., & Nicolaou, K. C. (1999) · Biochemistry · doi:10.1021/bi983023n · Cited by 159 · see citing works

Novel molecules that interact with microtubules and have functional activity similar to Taxol™

He, L., Orr, G. A., & Horwitz, S. B. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02038-4 · Cited by 144 · see citing works

Fast Kinetics of Taxol Binding to Microtubules

Díaz, J. F., Barasoaı́n, I., & Andreu, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211163200 · Cited by 135 · see citing works

Molecular Recognition of Taxol by Microtubules

Díaz, J. F., Strobe, R., Engelborghs, Y., Souto, A. A., & Andreu, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003120200 · Cited by 133 · see citing works

Taccalonolides E and A: Plant-derived steroids with microtubule-stabilizing activity.

Tinley, T. L., Randall‐Hlubek, D. A., Leal, R. M., Jackson, E. M., Cessac, J. W., Quada, J. C., Hemscheidt, T. K., & Mooberry, S. L. (2003) · PubMed · Cited by 126 · see citing works

Dicoumarol: a unique microtubule stabilizing natural product that is synergistic with Taxol.

Madari, H. S., Panda, D., Wilson, L., & Jacobs, R. S. (2003) · PubMed · Cited by 123 · see citing works

Interaction of Epothilone Analogs with the Paclitaxel Binding Site

Buey, R. M., Díaz, J. F., Andreu, J. M., O’Brate, A., Giannakakou, P., Nicolaou, K. C., Sasmal, P. K., Ritzén, A., & Namoto, K. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.01.014 · Cited by 121 · see citing works

Structural parameterization of the binding enthalpy of small ligands

Luque, I., & Freire, E. (2002) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.10208 · Cited by 120 · see citing works

Total Synthesis and Configurational Assignment of (−)‐Dictyostatin, a Microtubule‐Stabilizing Macrolide of Marine Sponge Origin

Paterson, I., Britton, R., Delgado, Ó., Meyer, A., & Poullennec, K. G. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200460589 · Cited by 115 · see citing works

The Synergistic Combination of the Farnesyl Transferase Inhibitor Lonafarnib and Paclitaxel Enhances Tubulin Acetylation and Requires a Functional Tubulin Deacetylase

Marcus, A. I., Zhou, J., O’Brate, A., Hamel, E., Wong, J. Y. Y., Nivens, M. C., El‐Naggar, A. K., Yao, T., Khuri, F. R., & Giannakakou, P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3757 · Cited by 109 · see citing works

Thermodynamics of ligand-induced assembly of tubulin

Díaz, J. F., Menéndez, M., & Andreu, J. M. (1993) · Biochemistry · doi:10.1021/bi00089a023 · Cited by 104 · see citing works

Taxanes in combined modality therapy for solid tumors

Choy, H. (2001) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(00)00112-8 · Cited by 82 · see citing works

Vinblastine and microtubules

Bryan, J. (1971) · Experimental Cell Research · doi:10.1016/s0014-4827(71)80020-4 · Cited by 82 · see citing works

The Interaction of Baccatin III with the Taxol Binding Site of Microtubules Determined by a Homogeneous Assay with Fluorescent Taxoid

Andreu, J. M., & Barasoaı́n, I. (2001) · Biochemistry · doi:10.1021/bi010869+ · Cited by 76 · see citing works

Inhibition of microtubules and cell cycle arrest by a new 1-deaza-7,8-dihydropteridine antitumor drug, CI 980, and by its chiral isomer, NSC 613863.

de Inés, C., Leynadier, D., Barasoaı́n, I., Peyrot, V., Garcia, P., Briand, C. M., Rener, G. A., & TEMPLE, C. J. (1994) · PubMed · Cited by 71 · see citing works

New Microtubule / Tubulin-Targeted Anticancer Drugs and Novel Chemotherapeutic Strategies

Wilson, L., & Jordan, M. A. (2004) · Journal of Chemotherapy · doi:10.1179/joc.2004.16.supplement-1.83 · Cited by 68 · see citing works

Cyclostreptin (FR182877), an Antitumor Tubulin-Polymerizing Agent Deficient in Enhancing Tubulin Assembly Despite Its High Affinity for the Taxoid Site

Edler, M., Buey, R. M., Gussio, R., Marcus, A. I., Vanderwal, C. D., Sorensen, E. J., Díaz, J. F., Giannakakou, P., & Hamel, E. (2005) · Biochemistry · doi:10.1021/bi050660m · Cited by 64 · see citing works

Synthesis of B-Ring Homologated Estradiol Analogues that Modulate Tubulin Polymerization and Microtubule Stability

Wang, Z., Yang, D., Mohanakrishnan, A. K., Fanwick, P. E., Nampoothiri, P., Hamel, E., & Cushman, M. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm0001119 · Cited by 62 · see citing works

Biological properties of jatrophane polyesters, new microtubule-interacting agents

Miglietta, A., Gabriel, L., Appendino, G., & Bocca, C. (2003) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-002-0541-4 · Cited by 59 · see citing works

A Steroid Derivative with Paclitaxel-Like Effects on Tubulin Polymerization

Verdier‐Pinard, P., Wang, Z., Mohanakrishnan, A. K., Cushman, M., & Hamel, E. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)26423-3 · Cited by 58 · see citing works

Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site††This work was presented in part at the Association for Research in Vision and Ophthalmology annual meetings May 1999 and May 2000, Fort Lauderdale, FL, USA and at the Schepens Eye Research Institute's 50th Anniversary Symposium, October 2000.‡‡The nucleotide sequences reported in this paper have been submitted to the GenBankTM with accession numbers AF141347, AF141348, AF141349, AF141923, and AF147880.

Crabtree, D. V., Ojima, I., Geng, X., & Adler, A. J. (2001) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(01)00103-1 · Cited by 49 · see citing works

Total Synthesis of (+)-Discodermolide: An Improved Endgame Exploiting a Still−Gennari-Type Olefination with a C1−C8 β-Ketophosphonate Fragment

Paterson, I., & Lyothier, I. (2004) · Organic Letters · doi:10.1021/ol0478842 · Cited by 47 · see citing works

Interaction of Epothilone Analogs with the Paclitaxel Binding SiteRelationship between Binding Affinity, Microtubule Stabilization, and Cytotoxicity

Buey, R. M., Díaz, J. F., Andreu, J. M., O’Brate, A., Giannakakou, P., Nicolaou, K. C., Sasmal, P. K., Ritzén, A., & Namoto, K. (2004) · Chemistry & Biology · doi:10.1016/s1074-5521(04)00025-0 · Cited by 41 · see citing works

Correlation of the in vivo anticoagulant, antithrombotic, and antimetastatic efficacy of warfarin in the rat

Smith, G. F., Neubauer, B. L., Sundboom, J. L., Best, K. L., Goode, R. L., Tanzer, L. R., Merriman, R. L., Frank, J. D., & Herrmann, R. G. (1988) · Thrombosis Research · doi:10.1016/0049-3848(88)90184-3 · Cited by 37 · see citing works

Comparative study of the colchicine binding site and the assembly of fish and mammalian microtubule proteins

de Pereda, J. M., Wallin, M., Billger, M. A., & Andreu, J. M. (1995) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970300207 · Cited by 11 · see citing works

Total Synthesis of (+)‐Discodermolide: An Improved Endgame Exploiting a Still—Gennari‐Type Olefination with a C1—C8 β‐Ketophosphonate Fragment.

Paterson, I., & Lyothier, I. (2005) · ChemInform · doi:10.1002/chin.200519227 · Cited by 4 · see citing works

Microtubule-binding agents: a dynamic field of cancer therapeutics

Dumontet, C., & Jordan, M. A. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3253 · Cited by 1,730 · see citing works

Coumarins: Old Compounds with Novel Promising Therapeutic Perspectives

Riveiro, M., KIMPE, N. D., Moglioni, A. G., Vázquez, R., Monczor, F., Shayo, C., & Davio, C. A. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790936284 · Cited by 448 · see citing works

Microtubule dynamics as a target in oncology

Risinger, A. L., Giles, F. J., & Mooberry, S. L. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.11.001 · Cited by 250 · see citing works

Anticancer drugs from nature—natural products as a unique source of new microtubule-stabilizing agents

Altmann, K., & Gertsch, J. (2007) · Natural Product Reports · doi:10.1039/b515619j · Cited by 249 · see citing works

Insights into the Distinct Mechanisms of Action of Taxane and Non-Taxane Microtubule Stabilizers from Cryo-EM Structures

Kellogg, E. H., Hejab, N. M. A., Howes, S., Northcote, P., Miller, J. H., Díaz, J. F., Downing, K. H., & Nogales, E. (2017) · Journal of Molecular Biology · doi:10.1016/j.jmb.2017.01.001 · Cited by 234 · see citing works

Recent advances in trimethoxyphenyl (TMP) based tubulin inhibitors targeting the colchicine binding site

Li, L., Jiang, S., Li, X., Liu, Y., Su, J., & Chen, J. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.04.011 · Cited by 231 · see citing works

Arylthioindole Inhibitors of Tubulin Polymerization. 3. Biological Evaluation, Structure−Activity Relationships and Molecular Modeling Studies

Regina, G. L., Edler, M., Brancale, A., Kandil, S., Coluccia, A., Piscitelli, F., Hamel, E., Martino, G. D., Matesanz, R., Díaz, J. F., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm061479u · Cited by 213 · see citing works

Microtubule Stabilizing Agents as Potential Treatment for Alzheimer’s Disease and Related Neurodegenerative Tauopathies

Ballatore, C., Brunden, K. R., Huryn, D. M., Trojanowski, J. Q., Lee, V. M. ‐., & Smith, A. B. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm301079z · Cited by 197 · see citing works

Overcoming tumor multidrug resistance using drugs able to evade P‐glycoprotein or to exploit its expression

Nobili, S., Landini, I., Mazzei, T., & Mini, E. (2011) · Medicinal Research Reviews · doi:10.1002/med.20239 · Cited by 183 · see citing works

Morlin, an inhibitor of cortical microtubule dynamics and cellulose synthase movement

DeBolt, S., Gutierrez, R., Ehrhardt, D. W., Melo, C. V., Ross, L., Cutler, S. R., Somerville, C. R., & Bonetta, D. T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700789104 · Cited by 160 · see citing works

Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites

Buey, R. M., Calvo, E., Barasoain, I., Pineda, O., Edler, M. C., Matesanz, R., Cerezo, G., Vanderwal, C. D., Day, B. W., Sorensen, E. J., et al. (2007) · Nature Chemical Biology · doi:10.1038/nchembio853 · Cited by 156 · see citing works

Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment

Negi, A. S., Gautam, Y., Alam, S., Chanda, D., Luqman, S., Sarkar, J., Khan, F., & Konwar, R. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.12.027 · Cited by 143 · see citing works

Synergistic Effects of Peloruside A and Laulimalide with Taxoid Site Drugs, but Not with Each Other, on Tubulin Assembly

Hamel, E., Day, B. W., Miller, J. H., Jung, M. K., Northcote, P. T., Ghosh, A. K., Curran, D. P., Cushman, M., Nicolaou, K. C., Paterson, I., et al. (2006) · Molecular Pharmacology · doi:10.1124/mol.106.027847 · Cited by 131 · see citing works

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

Rohena, C. C., & Mooberry, S. L. (2014) · Natural Product Reports · doi:10.1039/c3np70092e · Cited by 128 · see citing works

Colchicine Alkaloids and Synthetic Analogues: Current Progress and Perspectives

Gracheva, I. A., Shchegravina, E. S., Schmalz, H., Beletskaya, I. P., & Fedorov, A. Y. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c00222 · Cited by 126 · see citing works

The Taccalonolides: Microtubule Stabilizers That Circumvent Clinically Relevant Taxane Resistance Mechanisms

Risinger, A. L., Jackson, E. M., Polin, L., Helms, G. L., LeBoeuf, D. A., Joe, P. A., Hopper-Borge, E. A., Ludueña, R. F., Kruh, G. D., & Mooberry, S. L. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2037 · Cited by 124 · see citing works

A Unique Mode of Microtubule Stabilization Induced by Peloruside A

Huzil, J. T., Chik, J. K., Slysz, G., Freedman, H., Tuszyński, J. A., Taylor, R. E., Sackett, D. L., & Schriemer, D. C. (2008) · Journal of Molecular Biology · doi:10.1016/j.jmb.2008.03.026 · Cited by 123 · see citing works

The Binding Sites of Microtubule-Stabilizing Agents

Field, J. J., Díaz, J. F., & Miller, J. H. (2013) · Chemistry & Biology · doi:10.1016/j.chembiol.2013.01.014 · Cited by 119 · see citing works

Microtubule-Binding Natural Products for Cancer Therapy

Yue, Q., Liu, X., & Guo, D. (2010) · Planta Medica · doi:10.1055/s-0030-1250073 · Cited by 114 · see citing works

The Nucleotide Switch of Tubulin and Microtubule Assembly: A Polymerization-Driven Structural Change

Buey, R. M., Díaz, J. F., & Andreu, J. M. (2006) · Biochemistry · doi:10.1021/bi060334m · Cited by 118 · see citing works

Leiodermatolide, a Potent Antimitotic Macrolide from the Marine Sponge Leiodermatium sp.

Paterson, I., Dalby, S. M., Roberts, J. C., Naylor, G. J., Guzmán, E. A., Isbrucker, R. A., Pitts, T. P., Linley, P., Divlianska, D. B., Reed, J. K., et al. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007719 · Cited by 96 · see citing works

Ciliary central apparatus structure reveals mechanisms of microtubule patterning

Gui, M., Wang, X., Dutcher, S. K., Brown, A., & Zhang, R. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00770-2 · Cited by 97 · see citing works

Structure of the α-tubulin acetyltransferase, αTAT1, and implications for tubulin-specific acetylation

Friedmann, D. R., Aguilar, A., Fan, J., Nachury, M. V., & Marmorstein, R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209357109 · Cited by 85 · see citing works

Zampanolide, a Potent New Microtubule-Stabilizing Agent, Covalently Reacts with the Taxane Luminal Site in Tubulin α,β-Heterodimers and Microtubules

Field, J. J., Pera, B., Calvo, E., Canales, Á., Zurwerra, D., Trigili, C., Rodríguez‐Salarichs, J., Matesanz, R., Kanakkanthara, A., Wakefield, S. J., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.05.008 · Cited by 85 · see citing works

Triazolopyrimidines Are Microtubule-Stabilizing Agents that Bind the Vinca Inhibitor Site of Tubulin

Sáez-Calvo, G., Sharma, A., Balaguer, F. D. A., Barasoaı́n, I., Rodríguez‐Salarichs, J., Olieric, N., Muñoz-Hernández, H., Berbis, M. A., Wendeborn, S. V., Peñalva, M. A., et al. (2017) · Cell chemical biology · doi:10.1016/j.chembiol.2017.05.016 · Cited by 84 · see citing works

Microtubule-stabilizing agents: New drug discovery and cancer therapy

Zhao, Y., Mu, X. L., & Du, G. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.12.006 · Cited by 83 · see citing works

Cryo-EM structure of cortical microtubules from human parasite Toxoplasma gondii identifies their microtubule inner proteins

Wang, X., Fu, Y., Beatty, W. L., Ma, M., Brown, A., Sibley, L. D., & Zhang, R. (2021) · Nature Communications · doi:10.1038/s41467-021-23351-1 · Cited by 81 · see citing works

(+)-Discodermolide: total synthesis, construction of novel analogues, and biological evaluation

Smith, A. B., & Freeze, B. S. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.10.039 · Cited by 80 · see citing works

What tubulin drugs tell us about microtubule structure and dynamics

Amos, L. (2011) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2011.09.014 · Cited by 80 · see citing works

Optimization of Taxane Binding to Microtubules: Binding Affinity Dissection and Incremental Construction of a High-Affinity Analog of Paclitaxel

Matesanz, R., Barasoaı́n, I., Yang, C., Wang, L., Li, X., de Inés, C., Coderch, C., Gago, F., Jiménez‐Barbero, J., Andreu, J. M., et al. (2008) · Chemistry & Biology · doi:10.1016/j.chembiol.2008.05.008 · Cited by 79 · see citing works

Dietary flavonoid fisetin binds to β-tubulin and disrupts microtubule dynamics in prostate cancer cells

Mukhtar, E., Adhami, V. M., Sechi, M., & Mukhtar, H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.030 · Cited by 77 · see citing works

Novel Natural Product- and Privileged Scaffold-Based Tubulin Inhibitors Targeting the Colchicine Binding Site

Dong, M., Liu, F., Zhou, H., Zhai, S., & Yan, B. (2016) · Molecules · doi:10.3390/molecules21101375 · Cited by 77 · see citing works

Streamlined Syntheses of (−)-Dictyostatin, 16-Desmethyl-25,26-dihydrodictyostatin, and 6-epi-16-Desmethyl-25,26-dihydrodictyostatin

Zhu, W., Jiménez, M. J., Jung, W., Camarco, D. P., Balachandran, R., Vogt, A., Day, B. W., & Curran, D. P. (2010) · Journal of the American Chemical Society · doi:10.1021/ja103537u · Cited by 74 · see citing works

Structural insight into the stabilization of microtubules by taxanes

Prota, A. E., Lucena-Agell, D., Ma, Y., Estevez-Gallego, J., Li, S., Bargsten, K., Josa-Prado, F., Altmann, K.-H., Gaillard, N., Kamimura, S., et al. (2023) · eLife · doi:10.7554/elife.84791 · Cited by 78 · see citing works

Mechanism of microtubule stabilization by taccalonolide AJ

Wang, Y., Yu, Y., Li, G., Li, S., Wu, C., Gigant, B., Qin, W., Chen, H., Wu, Y., Chen, Q., et al. (2017) · Nature Communications · doi:10.1038/ncomms15787 · Cited by 71 · see citing works

Microtubule targeting agents: from biophysics to proteomics

Calligaris, D., Verdier‐Pinard, P., Devred, F., Villard, C., Braguer, D., & Lafitte, D. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0245-6 · Cited by 70 · see citing works

The Bound Conformation of Microtubule‐Stabilizing Agents: NMR Insights into the Bioactive 3D Structure of Discodermolide and Dictyostatin

Canales, Á., Matesanz, R., Gardner, N. M., Andreu, J. M., Paterson, I., Díaz, J. F., & Jiménez‐Barbero, J. (2008) · Chemistry - A European Journal · doi:10.1002/chem.200800039 · Cited by 69 · see citing works

Thermosensitive Betulinic Acid-Loaded Magnetoliposomes: A Promising Antitumor Potential for Highly Aggressive Human Breast Adenocarcinoma Cells Under Hyperthermic Conditions

Watz, C. G., Dehelean, C. A., Pînzaru, I., Mioc, M., Socoliuc, V., Moacă, E.-A., Avram, Ș., Ghiulai, R. M., Coricovac, D. E., Pavel, I., et al. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s269630 · Cited by 68 · see citing works

Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984–2019)

Fattahian, M., Ghanadian, M., Ali, Z., & Khan, I. A. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09667-8 · Cited by 65 · see citing works

The Tubulin‐Bound Conformation of Discodermolide Derived by NMR Studies in Solution Supports a Common Pharmacophore Model for Epothilone and Discodermolide

Sánchez‐Pedregal, V. M., Kubíček, K., Meiler, J., Lyothier, I., Paterson, I., & Carlomagno, T. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200602793 · Cited by 64 · see citing works

Potent Taccalonolides, AF and AJ, Inform Significant Structure–Activity Relationships and Tubulin as the Binding Site of These Microtubule Stabilizers

Li, J., Risinger, A. L., Peng, J., Chen, Z., Hu, L., & Mooberry, S. L. (2011) · Journal of the American Chemical Society · doi:10.1021/ja209045k · Cited by 63 · see citing works

Factorial design-optimized and gamma irradiation-assisted fabrication of selenium nanoparticles by chitosan and Pleurotus ostreatus fermented fenugreek for a vigorous in vitro effect against carcinoma cells

El-Batal, A. I., Mosallam, F. M., Ghorab, M. M., Hanora, A., Gobara, M., Baraka, A., Elsayed, M. A., Pal, K., Fathy, R. M., Elkodous, M. A., et al. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.11.210 · Cited by 63 · see citing works

Microtubule Stability Studied by Three-Dimensional Molecular Theory of Solvation

Drabik, P., Gusarov, S., & Kovalenko, A. (2006) · Biophysical Journal · doi:10.1529/biophysj.106.089987 · Cited by 63 · see citing works

Structural model for differential cap maturation at growing microtubule ends

Estévez-Gallego, J., Josa-Prado, F., Ku, S., Buey, R. M., Balaguer, F. A., Prota, A. E., Lucena-Agell, D., Kamma-Lorger, C., Yagi, T., Iwamoto, H., et al. (2020) · eLife · doi:10.7554/elife.50155 · Cited by 65 · see citing works

New Interfacial Microtubule Inhibitors of Marine Origin, PM050489/PM060184, with Potent Antitumor Activity and a Distinct Mechanism

Pera, B., Barasoaı́n, I., Pantazopoulou, A., Canales, Á., Matesanz, R., Rodríguez‐Salarichs, J., García‐Fernández, L., Moneo, V., Jiménez‐Barbero, J., Galmarini, C. M., et al. (2013) · ACS Chemical Biology · doi:10.1021/cb400461j · Cited by 60 · see citing works

New microtubule-inhibiting anticancer agents

Chen, S.-M., Meng, L., & Ding, J. H. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903571631 · Cited by 58 · see citing works

Conformation–activity relationships of polyketide natural products

Larsen, E. M., Wilson, M. R., & Taylor, R. E. (2015) · Natural Product Reports · doi:10.1039/c5np00014a · Cited by 58 · see citing works

Synthesis and biological evaluation of (−)-dictyostatin and stereoisomers

Shin, Y., Fournier, J., Brückner, A. M., Madiraju, C., Balachandran, R., Raccor, B. S., Edler, M., Hamel, E., Sikorski, R. P., Vogt, A., et al. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.05.033 · Cited by 57 · see citing works

PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors

Martínez, M., Guillen-Navarro, M. J., Pera, B., Bouchet, B. P., Martínez-Leal, J. F., Barasoaı́n, I., Cuevas, C., Andreu, J. M., García‐Fernández, L., Díaz, J. F., et al. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.026 · Cited by 56 · see citing works

An overview of microtubule targeting agents for cancer therapy

Karahalıl, B., Yardım-Akaydin, S., & Baytaş, S. N. (2019) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/aiht-2019-70-3258 · Cited by 54 · see citing works

Structure–activity relationships of novel substituted naphthalene diimides as anticancer agents

Milelli, A., Tumiatti, V., Micco, M., Rosini, M., Zuccari, G., Raffaghello, L., Bianchi, G., Pistoia, V., Díaz, J. F., Pera, B., et al. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.06.045 · Cited by 50 · see citing works

Insights into the Interaction of Discodermolide and Docetaxel with Tubulin. Mapping the Binding Sites of Microtubule-Stabilizing Agents by Using an Integrated NMR and Computational Approach

Canales, Á., Rodríguez‐Salarichs, J., Trigili, C., Nieto, L., Coderch, C., Andreu, J. M., Paterson, I., Jiménez‐Barbero, J., & Díaz, J. F. (2011) · ACS Chemical Biology · doi:10.1021/cb200099u · Cited by 50 · see citing works

Total Synthesis and Biological Evaluation of C16 Analogs of (−)-Dictyostatin

Jung, W.-H., Harrison, C. L., Shin, Y., Fournier, J., Balachandran, R., Raccor, B. S., Sikorski, R. P., Vogt, A., Curran, D. P., & Day, B. W. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm061385k · Cited by 50 · see citing works

Analysis of the Strength of Interfacial Hydrogen Bonds between Tubulin Dimers Using Quantum Theory of Atoms in Molecules

Ayoub, A. T., Craddock, T. J. A., Kłobukowski, M., & Tuszyński, J. A. (2014) · Biophysical Journal · doi:10.1016/j.bpj.2014.05.047 · Cited by 49 · see citing works

Design and Synthesis of Pironetin Analogue/Colchicine Hybrids and Study of Their Cytotoxic Activity and Mechanisms of Interaction with Tubulin

Vilanova, C., Díaz‐Oltra, S., Murga, J., Falomir, E., Cardá, M., Redondo‐Horcajo, M., Díaz, J. F., Barasoaı́n, I., & Marco, J. A. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501112q · Cited by 48 · see citing works

Identification and Biological Activities of New Taccalonolide Microtubule Stabilizers

Peng, J., Risinger, A. L., Fest, G. A., Jackson, E. M., Helms, G. L., Polin, L., & Mooberry, S. L. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200757g · Cited by 47 · see citing works

Distinct Pose of Discodermolide in Taxol Binding Pocket Drives a Complementary Mode of Microtubule Stabilization

Baine, M. K., Menon, V., Verdier‐Pinard, P., Smith, A. B., Angeletti, R. H., Fiser, A., Horwitz, S. B., & Xiao, H. (2009) · Biochemistry · doi:10.1021/bi901351q · Cited by 47 · see citing works

Overcoming Tumor Drug Resistance with High‐Affinity Taxanes: A SAR Study of C2‐Modified 7‐Acyl‐10‐Deacetyl Cephalomannines

Yang, C., Barasoaı́n, I., Li, X., Matesanz, R., Liu, R., Sharom, F. J., Yin, D., Díaz, J. F., & Fang, W. (2007) · ChemMedChem · doi:10.1002/cmdc.200700002 · Cited by 46 · see citing works

Synthesis and biological evaluation of novel analogues of dictyostatin

Paterson, I., Gardner, N. M., Poullennec, K. G., & Wright, A. E. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.02.031 · Cited by 46 · see citing works

Natural Products from the Lithistida: A Review of the Literature since 2000

Winder, P. L., Pomponi, S. A., & Wright, A. E. (2011) · Marine Drugs · doi:10.3390/md9122643 · Cited by 46 · see citing works

Bacterial Tubulin Distinct Loop Sequences and Primitive Assembly Properties Support Its Origin from a Eukaryotic Tubulin Ancestor

Martín-Galiano, A. J., Oliva, M. A., Sanz, L., Bhattacharyya, A., Serna, M., Yébenes, H., Valpuesta, J., & Andreu, J. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.230094 · Cited by 45 · see citing works

Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies

Ballatore, C., Brunden, K. R., Trojanowski, J. Q., Lee, V. M. Y., Smith, A. B., & Huryn, D. M. (2010) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611794072605 · Cited by 44 · see citing works

A Highly Step‐Economical Synthesis of Dictyostatin

Ho, S., Bucher, C., & Leighton, J. L. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201302565 · Cited by 43 · see citing works

Large Scale Purification of Brain Tubulin With the Modified Weisenberg Procedure

Andreu, J. M. (2007) · Methods in molecular medicine · doi:10.1007/978-1-59745-442-1_2 · Cited by 43 · see citing works

Zampanolide and dactylolide: cytotoxic tubulin-assembly agents and promising anticancer leads

Chen, Q., & Kingston, D. G. I. (2014) · Natural Product Reports · doi:10.1039/c4np00024b · Cited by 42 · see citing works

Recent Advances in the Study of the Bioactive Conformation of Taxol

Sun, L. D., Simmerling, C. L., & Ojima, I. (2009) · ChemMedChem · doi:10.1002/cmdc.200900044 · Cited by 41 · see citing works

Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activation

Sánchez‐Carranza, J. N., az, J. D. ⁄., Redondo‐Horcajo, M., Barasoaı́n, I., Álvarez, L., Lastres, P., Romero-Estrada, A., Aller, P., & lez‐Maya, L. G. ⁄. (2018) · Oncology Reports · doi:10.3892/or.2018.6382 · Cited by 41 · see citing works

Synthetic Studies toward Jatrophane Diterpenes from Euphorbia characias. Enantioselective Synthesis of (−)-15-O-Acetyl-3-O-propionyl-17-norcharaciol

Helmboldt, H., & Hiersemann, M. (2009) · The Journal of Organic Chemistry · doi:10.1021/jo802581g · Cited by 40 · see citing works

Fluorescence Spectroscopic Methods to Analyze Drug–Tubulin Interactions

Bhattacharyya, B., Kapoor, S., & Panda, D. (2010) · Methods in cell biology · doi:10.1016/s0091-679x(10)95017-6 · Cited by 39 · see citing works

Taccalonolide microtubule stabilizers

Li, J., Risinger, A. L., & Mooberry, S. L. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.01.012 · Cited by 37 · see citing works

Structural Basis of Microtubule Stabilization by Discodermolide

Prota, A. E., Bargsten, K., Redondo‐Horcajo, M., Smith, A. B., Yang, C. H., McDaid, H. M., Paterson, I., Horwitz, S. B., Díaz, J. F., & Steinmetz, M. O. (2017) · ChemBioChem · doi:10.1002/cbic.201600696 · Cited by 38 · see citing works

Dissecting Paclitaxel–Microtubule Association: Quantitative Assessment of the 2′-OH Group

Sharma, S., Lagisetti, C., Poliks, B., Coates, R. M., Kingston, D. G. I., & Bane, S. (2013) · Biochemistry · doi:10.1021/bi400014t · Cited by 38 · see citing works

Total synthesis of a library of designed hybrids of the microtubule-stabilising anticancer agents taxol, discodermolide and dictyostatin

Paterson, I., Naylor, G. J., Fujita, T., Guzmán, E. A., & Wright, A. E. (2009) · Chemical Communications · doi:10.1039/b921237j · Cited by 38 · see citing works

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

Risinger, A. L., Riffle, S., Lopus, M., Jordan, M. A., Wilson, L., & Mooberry, S. L. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-41 · Cited by 38 · see citing works

The Protein Farnesyltransferase Regulates HDAC6 Activity in a Microtubule-dependent Manner

Zhou, J., Vos, C. C., Gjyrezi, A., Yoshida, M., Khuri, F. R., Tamanoi, F., & Giannakakou, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808708200 · Cited by 38 · see citing works

Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action

Artola, M., Ruiz-Ávila, L. B., Vergoñós, A., Huecas, S., Araújo‐Bazán, L., Martín‐Fontecha, M., Vázquez‐Villa, H., Turrado, C., Ramírez-Aportela, E., Hoegl, A., et al. (2014) · ACS Chemical Biology · doi:10.1021/cb500974d · Cited by 37 · see citing works

Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances

Matesanz, R., Trigili, C., Rodríguez‐Salarichs, J., Zanardi, I., Pera, B., Nogales, A., Fang, W., Jiménez‐Barbero, J., Canales, Á., Barasoaı́n, I., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.05.048 · Cited by 36 · see citing works

Farnesyltransferase Inhibitors Reverse Taxane Resistance

Marcus, A. I., O’Brate, A., Buey, R. M., Zhou, J., Thomas, S. L., Khuri, F. R., Andreu, J. M., Díaz, F., & Giannakakou, P. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0699 · Cited by 36 · see citing works

Design, synthesis and biological evaluation of a macrocyclic discodermolide/dictyostatin hybrid

Paterson, I., & Gardner, N. M. (2006) · Chemical Communications · doi:10.1039/b615122a · Cited by 36 · see citing works

Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules

Marco, J. A., García-Pla, J., Cardá, M., Murga, J., Falomir, E., Trigili, C., Notararigo, S., Díaz, J. F., & Barasoaı́n, I. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.02.011 · Cited by 35 · see citing works

Drug target interaction of tubulin-binding drugs in cancer therapy

Sengupta, S., & Thomas, S. A. (2006) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.6.10.1433 · Cited by 35 · see citing works

Modulation of Microtubule Interprotofilament Interactions by Modified Taxanes

Matesanz, R., Rodríguez‐Salarichs, J., Pera, B., Canales, Á., Andreu, J. M., Jiménez‐Barbero, J., Bras, W., Nogales, A., Fang, W., & Díaz, J. F. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.005 · Cited by 32 · see citing works

Keratin nanoparticles co-delivering Docetaxel and Chlorin e6 promote synergic interaction between chemo- and photo-dynamic therapies

Gaio, E., Guerrini, A., Ballestri, M., Varchi, G., Ferroni, C., Martella, E., Columbaro, M., Moret, F., & Reddi, E. (2019) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2019.111598 · Cited by 34 · see citing works

Taccalonolides: Novel microtubule stabilizers with clinical potential

Risinger, A. L., & Mooberry, S. L. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.09.020 · Cited by 34 · see citing works

Indazole-based microtubule-targeting agents as potential candidates for anticancer drugs discovery

Pal, D., Song, I., Warkad, S. D., Song, K., Yeom, G. S., Saha, S., Shinde, P. B., & Nimse, S. B. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105735 · Cited by 33 · see citing works

Total Synthesis and Biological Evaluation of a Series of Macrocyclic Hybrids and Analogues of the Antimitotic Natural Products Dictyostatin, Discodermolide, and Taxol

Paterson, I., Naylor, G. J., Gardner, N. M., Guzmán, E. A., & Wright, A. E. (2010) · Chemistry - An Asian Journal · doi:10.1002/asia.201000541 · Cited by 32 · see citing works

Design, synthesis, and biological evaluation of novel combretastatin A-4 thio derivatives as microtubule targeting agents

Stefański, T., Mikstacka, R., Kurczab, R., Dutkiewicz, Z., Kucińska, M., Murias, M., Zielińska‐Przyjemska, M., Cichocki, M., Teubert, A., Kaczmarek, M., et al. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.11.050 · Cited by 32 · see citing works

Total synthesis of a potent hybrid of the anticancer natural products dictyostatin and discodermolide

Paterson, I., Naylor, G. J., & Wright, A. E. (2008) · Chemical Communications · doi:10.1039/b811575c · Cited by 32 · see citing works

Tedanolide and the evolution of polyketide inhibitors of eukaryotic protein synthesis

Taylor, R. E. (2008) · Natural Product Reports · doi:10.1039/b805700c · Cited by 32 · see citing works

Hispidin induces autophagic and necrotic death in SGC-7901 gastric cancer cells through lysosomal membrane permeabilization by inhibiting tubulin polymerization

Lv, L., Zhou, Z. M., Zhou, Z., Zhang, L.-J., Yan, R., Zhao, Z., Yang, L., Bian, X.-Y., Jiang, H., Li, Y.-D., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15935 · Cited by 31 · see citing works

Antitumor Activity of Lankacidin Group Antibiotics Is Due to Microtubule Stabilization via a Paclitaxel-like Mechanism

Ayoub, A. T., El-Magd, R. M. A., Xiao, J., Lewis, C. W., Tilli, T. M., Arakawa, K., Nindita, Y., Chan, G. K. T., Sun, L., Glover, M., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01264 · Cited by 30 · see citing works

Site occupancy calibration of taxane pharmacology in live cells and tissues

Pineda, J. J., Miller, M. A., Song, Y., Kuhn, H., Mikula, H., Tallapragada, N. P., Weissleder, R., & Mitchison, T. J. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800047115 · Cited by 30 · see citing works

Elucidating the Mechanism of Action of the Clinically Approved Taxanes: A Comprehensive Comparison of Local and Allosteric Effects

Churchill, C. D. M., Kłobukowski, M., & Tuszyński, J. A. (2015) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12595 · Cited by 29 · see citing works

Molecular Recognition of Epothilones by Microtubules and Tubulin Dimers Revealed by Biochemical and NMR Approaches

Canales, Á., Nieto, L., Rodríguez‐Salarichs, J., Sánchez‐Murcia, P. A., Coderch, C., Cortés-Cabrera, Á., Paterson, I., Carlomagno, T., Gago, F., Andreu, J. M., et al. (2014) · ACS Chemical Biology · doi:10.1021/cb400673h · Cited by 28 · see citing works

Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel

Risinger, A. L., & Mooberry, S. L. (2011) · Cell Cycle · doi:10.4161/cc.10.13.16238 · Cited by 28 · see citing works

Molecular Recognition of Peloruside A by Microtubules. The C24 Primary Alcohol is Essential for Biological Activity

Pera, B., Razzak, M., Trigili, C., Pineda, O., Canales, Á., Buey, R. M., Jiménez‐Barbero, J., Northcote, P. T., Paterson, I., Barasoaı́n, I., et al. (2010) · ChemBioChem · doi:10.1002/cbic.201000294 · Cited by 27 · see citing works

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

Balaguer, F. D. A., Mühlethaler, T., Estévez‐Gallego, J., Calvo, E., Giménez-Abián, J. F., Risinger, A. L., Sorensen, E. J., Vanderwal, C. D., Altmann, K., Mooberry, S. L., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20061392 · Cited by 28 · see citing works

Probing the Pore Drug Binding Site of Microtubules with Fluorescent Taxanes: Evidence of Two Binding Poses

Barasoaı́n, I., García-Carril, A. M., Matesanz, R., Maccari, G., Trigili, C., Mori, M., Shi, J.-Z., Fang, W., Andreu, J. M., Botta, M., et al. (2010) · Chemistry & Biology · doi:10.1016/j.chembiol.2010.02.006 · Cited by 25 · see citing works

(4-Methoxyphenyl)(3,4,5-trimethoxyphenyl)methanone inhibits tubulin polymerization, induces G2/M arrest, and triggers apoptosis in human leukemia HL-60 cells

Magalhães, H. I. F., Wilke, D. V., Bezerra, D. P., Cavalcanti, B. C., Rotta, R., de Lima, D. P., Beatriz, A., de Moraes, M. O., Diniz-Filho, J., & Pessoa, C. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.06.001 · Cited by 27 · see citing works

Synthesis and Biological Evaluation of 10,11-Dihydrodictyostatin, a Potent Analogue of the Marine Anticancer Agent Dictyostatin

Paterson, I., Gardner, N. M., Poullennec, K. G., & Wright, A. E. (2007) · Journal of Natural Products · doi:10.1021/np070547s · Cited by 27 · see citing works

Summary

Buey, R. M., Barasoaı́n, I., Jackson, E., Meyer, A., Giannakakou, P., Paterson, I., Mooberry, S. L., Andreu, J. M., Fern, J. P., Díaz, O., et al. (2013)

Interaction of Epothilone Analogs with the Paclitaxel Binding SiteRelationship between Binding Affinity, Microtubule Stabilization, and Cytotoxicity

Buey, R. M., Díaz, J. F., Andreu, J. M., O’Brate, A., Giannakakou, P., Nicolaou, K. C., Sasmal, P. K., Ritzén, A., & Namoto, K. (2004) · Chemistry & Biology · doi:10.1016/s1074-5521(04)00025-0 · Cited by 41 · see citing works

The Interaction of Microtubules with Stabilizers Characterized at Biochemical and Structural Levels

Díaz, J. F., Andreu, J. M., & Jiménez‐Barbero, J. (2008) · Topics in current chemistry · doi:10.1007/128_2008_12 · Cited by 15 · see citing works

Interaction of Epothilone Analogs with the Paclitaxel Binding Site

Buey, R. M., Díaz, J. F., Andreu, J. M., O’Brate, A., Giannakakou, P., Nicolaou, K. C., Sasmal, P. K., Ritzén, A., & Namoto, K. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.01.014 · Cited by 121 · see citing works

A common pharmacophore for cytotoxic natural products that stabilize microtubules

Ojima, I., Chakravarty, S., Inoue, T., Lin, S., He, L., Horwitz, S. B., Kuduk, S. D., & Danishefsky, S. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4256 · Cited by 250 · see citing works