Polyploidization in Liver Tissue
Open accessAbstract
Polyploidy (alias whole genome amplification) refers to organisms containing more than two basic sets of chromosomes. Polyploidy was first observed in plants more than a century ago, and it is known that such processes occur in many eukaryotes under a variety of circumstances. In mammals, the development of polyploid cells can contribute to tissue differentiation and, therefore, possibly a gain of function; alternately, it can be associated with development of disease, such as cancer. Polyploidy can occur because of cell fusion or abnormal cell division (endoreplication, mitotic slippage, or cytokinesis failure). Polyploidy is a common characteristic of the mammalian liver. Polyploidization occurs mainly during liver development, but also in adults with increasing age or because of cellular stress (eg, surgical resection, toxic exposure, or viral infections). This review will explore the mechanisms that lead to the development of polyploid cells, our current state of understanding of how polyploidization is regulated during liver growth, and its consequence on liver function.
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Higher ploidies (>8n) appear in injured livers, likely due to alterations to cell cycles caused by cellular damage.
“Higher ploidies (>8n) appear in injured livers, likely due to alterations to cell cycles caused by cellular damage.29”
From Distinct hepatocyte identities in liver homeostasis and regeneration (2023) · cites this paper as [29]
The “Polyploidy in the Liver” section (page unavailable) says liver injury modifies the ploidy profile and that some hepatocytes undergo incomplete cell cycles during regeneration. It does not establish that injured livers develop ploidies above 8n, and it says the mechanisms generating polyploid hepatocytes under cellular stress remain unknown. (LLM, conf=0.86)
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Cites
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- Authors
- Gentric, G., & Desdouets, C.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Desdouets, Chantal
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 184
- Issue
- 2
- Pages
- 322-331
- ISSN
- 0002-9440 (ISSN-L)
- OpenAlex
- W2116142842
- Cited by
- 192
- References
- 9
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 14 · 2023: 12 · 2022: 15 · 2021: 16 · 2020: 17 · 2019: 29 · 2018: 25 · 2017: 14 · 2016: 15 · 2015: 16 · 2014: 3 · 2013: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- American Society for Investigative Pathology
- Science Foundation Ireland
- Agence Nationale de la Recherche (ANR-10-BLAN-1123)
- Institut National de la Santé et de la Recherche Médicale
- Fondation ARC pour la Recherche sur le Cancer
- Association Française pour l'Etude du Foie
- Cilag
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Keywords
- polyploidy, polyploidization, liver, whole genome amplification, endoreplication, mitotic slippage, cytokinesis failure, cell fusion, liver development, cellular stress, liver function
- MeSH terms
- Animals, Cell Fusion, Humans, Liver, Polyploidy, Hepatocytes, Cytokinesis, Chromosome Duplication
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