Friedman, Jeffrey M.

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 13,419

Leptin and the regulation of body weight in mammals

Friedman, J. M., & Halaas, J. L. (1998) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 5,405

Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene

Halaas, J. L., Gajiwala, K. S., Maffei, M., Cohen, S. L., Chait, B. T., Rabinowitz, D., Lallone, R. L., Burley, S. K., & Friedman, J. M. (1995) · Science

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 4,451

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

Maffei, M., Halaas, J., Ravussin, E., Pratley, R. E., Lee, G. H., Zhang, Y., Fei, H., Kim, S., Lallone, R., Ranganathan, S., et al. (1995) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 3,725

Abnormal splicing of the leptin receptor in diabetic mice

Lee, G.-H., Proenca, R., Montez, J. M., Carroll, K. M., Darvishzadeh, J. G., Lee, J. I., & Friedman, J. M. (1996) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 2,327

The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy Homeostasis

Cowley, M. A., Smith, R. G., Diano, S., Tschöp, M., Pronchuk, N., Grove, K. L., Strasburger, C. J., Bidlingmaier, M., Esterman, M., Heiman, M. L., et al. (2003) · Neuron

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 1,679

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Chaudhury, D., Walsh, J. J., Friedman, A. K., Juarez, B., Ku, S. M., Koo, J. W., Ferguson, D., Tsai, H.-C., Pomeranz, L., Christoffel, D. J., et al. (2013) · Nature

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 1,156

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics

Regulation of Appetite and ObesityCytokine Signaling Pathways and Interactions

Cited by 1,086

Physiological response to long-term peripheral and central leptin infusion in lean and obese mice.

Halaas, J. L., Boozer, C., Blair-West, J., Fidahusein, N., Denton, D. A., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 1,033

Rapid Rewiring of Arcuate Nucleus Feeding Circuits by Leptin

Pinto, S., Roseberry, A. G., Liu, H., Diano, S., Shanabrough, M., Cai, X., Friedman, J. M., & Horvath, T. L. (2004) · Science

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 987

Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues.

Fei, H., Okano, H. J., Li, C., Lee, G.-H., Zhao, C., Darnell, R., & Friedman, J. M. (1997) · Proceedings of the National Academy of Sciences

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 766

Acute stimulation of glucose metabolism in mice by leptin treatment

Kamohara, S., Burcelin, R., Halaas, J. L., Friedman, J. M., & Charron, M. J. (1997) · Nature

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 708

Leptin and the endocrine control of energy balance

Friedman, J. M. (2019) · Nature Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 661

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

Zeng, W., Pirzgalska, R. M., Pereira, M. M. A., Kubasova, N., Barateiro, A., Seixas, E., Lu, Y.-H., Kozlova, A., Voss, H., Martins, G. G., et al. (2015) · Cell

Adipose Tissue and MetabolismRegulation of Appetite and Obesity

Cited by 490

Leptin targets in the mouse brain

Scott, M. M., Lachey, J. L., Sternson, S. M., Lee, C. E., Elias, C. F., Friedman, J. M., & Elmquist, J. K. (2009) · Journal of Comparative Neurology

Regulation of Appetite and ObesityHypothalamic control of reproductive hormones

Cited by 484

Whole population, genome-wide mapping of hidden relatedness

Gusev, A., Lowe, J. K., Stoffel, M., Daly, M. J., Altshuler, D., Breslow, J. L., Friedman, J. M., & Pe'er, I. (2009) · Genome Research

Genetic Associations and EpidemiologyForensic and Genetic Research

Cited by 450

A war on obesity, not the obese.

Friedman, J. M. (2003) · Science

Obesity and Health PracticesObesity, Physical Activity, Diet

Cited by 375

Modern science versus the stigma of obesity

Friedman, J. M. (2004) · Nature Medicine

Obesity and Health PracticesRegulation of Appetite and Obesity

Cited by 368

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

Wang, P., Loh, K. H., Wu, M., Morgan, D. A., Schneeberger, M., Yu, X., Chi, J., Kosse, C., Kim, D., Rahmouni, K., et al. (2020) · Nature

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 332

Hyperleptinemia Is Required for the Development of Leptin Resistance

Knight, Z. A., Hannan, K. S., Greenberg, M. L., & Friedman, J. M. (2010) · PLoS ONE

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 311

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2

Coppola, A., Liu, Z.-W., Andrews, Z. B., Paradis, E., Roy, M.-C., Friedman, J. M., Ricquier, D., Richard, D., Horvath, T. L., Gao, X.-B., et al. (2007) · Cell Metabolism

Regulation of Appetite and ObesityAdipose Tissue and Metabolism

Cited by 295

Antidiabetic Effects of IGFBP2, a Leptin-Regulated Gene

Hedbacker, K., Birsoy, K., Wysocki, R. W., Asilmaz, E., Ahima, R. S., Farooqi, I. S., & Friedman, J. M. (2010) · Cell Metabolism

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 280

Leptin at 14 y of age: an ongoing story

Friedman, J. M. (2009) · The American Journal of Clinical Nutrition

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 272

Site and mechanism of leptin action in a rodent form of congenital lipodystrophy

Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D., et al. (2004) · Journal of Clinical Investigation

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 210